Membranes,
Год журнала:
2024,
Номер
14(5), С. 95 - 95
Опубликована: Апрель 23, 2024
The
skin,
as
the
largest
organ,
serves
a
protective
barrier
against
external
stimuli.
However,
when
skin
is
injured,
wound
healing
becomes
complex
process
influenced
by
physiological
conditions,
bacterial
infections,
and
inflammation.
To
improve
of
healing,
variety
dressings
with
antibacterial
qualities
have
been
created.
Electrospun
nanofibers
gained
significant
attention
in
dressing
research
due
to
their
large
specific
surface
area
unique
structure.
One
interesting
method
for
creating
Janus-structured
side-by-side
electrospinning.
This
work
used
electrospinning
make
cellulose
acetate/gelatin
Janus
nanofibers.
Curcumin
zinc
oxide
nanoparticles
were
added
these
We
studied
nanofibers'
physicochemical
characteristics
abilities
regulate
small-molecule
medication
release.
coated
curcumin
also
tested
activity.
specified
successfully
fabricated.
Nanofibers
released
medicines
controlled
manner.
Additionally,
loaded
exhibited
excellent
capabilities.
contributes
development
advanced
promoting
combating
infections.
Nanoscale,
Год журнала:
2024,
Номер
16(17), С. 8573 - 8582
Опубликована: Янв. 1, 2024
Janus
nanoparticles
with
soluble
polyvinylpyrrolidone
patches
located
on
the
insoluble
Eudragit
RL100
sides
were
prepared
using
a
side-by-side
electrospraying
method
and
are
demonstrated
to
provide
biphasic
release
of
paracetamol
in
turn
faster
action
longer
time
periods
blood
drug
concentration
for
therapy.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4114 - 4144
Опубликована: Июнь 3, 2024
Nanofiber
scaffolds
have
gained
significant
attention
in
the
field
of
bone
tissue
engineering.
Electrospinning,
a
straightforward
and
efficient
technique
for
producing
nanofibers,
has
been
extensively
researched.
When
used
engineering
scaffolds,
electrospun
nanofibers
with
suitable
surface
properties
promote
new
growth
enhance
cell
adhesion.
Recent
advancements
electrospinning
technology
provided
innovative
approaches
scaffold
fabrication
This
review
comprehensively
examines
utilization
evaluates
relevant
literature.
The
begins
by
presenting
fundamental
principles
methodologies
electrospinning.
It
then
discusses
various
materials
production
nanofiber
engineering,
including
natural
synthetic
polymers,
as
well
certain
inorganic
materials.
challenges
associated
these
are
also
described.
focuses
on
novel
techniques
construction
such
multilayer
multifluid
electrospinning,
integration
other
methods.
enabled
precisely
aligned
nanoscale
architectures.
These
methods
facilitate
biomimetic
structures,
wherein
bioactive
substances
can
be
incorporated
released
controlled
manner
drug
delivery
purposes.
Moreover,
they
address
issues
encountered
traditional
mechanical
characteristics
biocompatibility.
Consequently,
development
implementation
technologies
revolutionized
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
654, С. 123972 - 123972
Опубликована: Март 7, 2024
A
core-sheath
structure
is
one
of
the
methods
developed
to
overcome
challenges
often
faced
when
using
monolithic
fibers
for
drug
delivery.
In
this
study,
based
on
polyvinylpyrrolidone
(core)
and
ethyl
cellulose
(sheath)
were
successfully
produced
a
novel
pressure-spinning
process.
For
comparison,
these
two
polymers
also
processed
into
as
blend
fibers.
All
samples
then
investigated
their
performances
in
releasing
water-soluble
ampicillin
(AMP)
poorly
ibuprofen
(IBU)
model
drugs.
Scanning
electron,digital
confocal
microscopy
confirmed
that
with
made.
Fourier
transform
infrared
spectroscopy
showed
success
technique
encapsulating
AMP/IBU
all
fiber
samples.
Compared
fibers,
had
better
performance
both
Moreover,
was
able
reduce
initial
burst
release
provided
sustained
profile
than
analog.
conclusion,
method
capable
producing
could
be
used
loading
either
hydrophilic
or
hydrophobic
drugs
controlled
delivery
systems.
