MBG/BSA Bone Grafts Immunomodulate Bone Regeneration by Releasing Bioactive Ions in Inflammatory Bone Defects DOI Open Access
Yijie Yang, Wen Gu, Xue Jiang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Abstract Since the diseases that cause bone defects are mostly inflammatory diseases, current grafts unable to effectively regulate osteoimmune activity, leading impaired osteogenesis and unfavorable regeneration. In this study, inspired by composition, biomimetic mesoporous bioactive glass nanoparticle (MBG)/bovine serum albumin (BSA) designed for defects. Systematically, MBG/BSA evaluated characterization, bioactivity, anti‐inflammatory, antioxidant osteogenic activity. proved be biocompatible can release ions including calcium silicon in a sustained manner. Furthermore, reprograms macrophage phenotype toward anti‐inflammation is beneficial The antioxidative activity also validated under inflammation mechanism may via interleukin‐4 (IL‐4)/Signal transducer activator of transcription 6 (STAT6) pathway. differentiation mineralization facilitated due improved immunoregulation MBG/BSA. Overall, work suggests with immunomodulatory properties an ideal material regeneration application.

Язык: Английский

MBG/BSA Bone Grafts Immunomodulate Bone Regeneration by Releasing Bioactive Ions in Inflammatory Bone Defects DOI Open Access
Yijie Yang, Wen Gu, Xue Jiang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Abstract Since the diseases that cause bone defects are mostly inflammatory diseases, current grafts unable to effectively regulate osteoimmune activity, leading impaired osteogenesis and unfavorable regeneration. In this study, inspired by composition, biomimetic mesoporous bioactive glass nanoparticle (MBG)/bovine serum albumin (BSA) designed for defects. Systematically, MBG/BSA evaluated characterization, bioactivity, anti‐inflammatory, antioxidant osteogenic activity. proved be biocompatible can release ions including calcium silicon in a sustained manner. Furthermore, reprograms macrophage phenotype toward anti‐inflammation is beneficial The antioxidative activity also validated under inflammation mechanism may via interleukin‐4 (IL‐4)/Signal transducer activator of transcription 6 (STAT6) pathway. differentiation mineralization facilitated due improved immunoregulation MBG/BSA. Overall, work suggests with immunomodulatory properties an ideal material regeneration application.

Язык: Английский

Процитировано

0