Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6012 - 6012
Опубликована: Май 30, 2024
In
exploring
the
challenges
of
bone
repair
and
regeneration,
this
review
evaluates
potential
tissue
engineering
(BTE)
as
a
viable
alternative
to
traditional
methods,
such
autografts
allografts.
Key
developments
in
biomaterials
scaffold
fabrication
techniques,
additive
manufacturing
cell
bioactive
molecule-laden
scaffolds,
are
discussed,
along
with
integration
bio-responsive
which
can
respond
physical
chemical
stimuli.
These
advancements
collectively
aim
mimic
natural
microenvironment
bone,
thereby
enhancing
osteogenesis
facilitating
formation
new
tissue.
Through
comprehensive
combination
vitro
vivo
studies,
we
scrutinize
biocompatibility,
osteoinductivity,
osteoconductivity
these
engineered
well
their
interactions
critical
cellular
players
healing
processes.
Findings
from
techniques
scaffolds
indicate
that
incorporating
nanostructured
materials
compounds
is
particularly
effective
promoting
recruitment
differentiation
osteoprogenitor
cells.
The
therapeutic
advanced
clinical
settings
widely
recognized
paper
advocates
continued
research
into
multi-responsive
systems.
Язык: Английский
Synergistic antibacterial activity of chitosan-polyethylene glycol nanocomposites films containing ZIF-8 and doxycycline
BMC Biotechnology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 20, 2025
Antibiotic
resistance
is
a
growing
global
threat
due
to
antibiotic
overuse
and
limited
treatment
options.
Multidrug-resistant
bacteria,
like
Staphylococcus
aureus
Escherichia
coli,
increase
infection
complexity
mortality.
This
study
explores
nanocomposite
films
of
ZIF-8
nanoparticles
Doxycycline
(Dox)
enhance
antibacterial
efficacy.
In
this
study,
composed
chitosan
(CS)
polyethylene
glycol
(PEG),
incorporating
zeolitic
imidazolate
framework-8
(ZIF-8)
DOX,
were
developed.
These
characterized
by
their
morphological,
mechanical,
antibacterial,
drug-release
properties.
Antibacterial
efficacy
was
evaluated
using
disk
diffusion,
broth
microdilution,
checkerboard
assay
methods
determine
MICs
potential
synergistic
effects.
The
demonstrated
flexibility,
semi-transparency,
yellowish-brown
hue,
with
containing
being
thicker
(79
±
0.2
μm)
than
those
without
(54
0.5
μm).
tensile
strength
enhanced
the
incorporation
ZIF-8,
peaking
at
53.12
MPa
for
CS-PEG-G-10%
DOX-4%
film.
XRD
analysis
confirmed
crystallinity
distinct
peaks
observed
each
material.
drug
release
studies
revealed
an
initial
burst
followed
sustained
release,
higher
rates
in
acidic
environments
compared
neutral
alkaline
media.
film
significantly
activity,
achieving
lowest
MIC
values,
particularly
against
S.
(22.5
mm
inhibition
zone)
E.
coli
(14
zone).
Additionally,
notable
effect
between
DOX
FICI
values
below
0.5.
exhibits
optimal
properties,
positioning
it
as
strong
candidate
developing
effective
treatments
multidrug-resistant
pathogens.
Язык: Английский
Crafting porous nanoscaled architecture as a potential frontier for drug delivery
Molecular Systems Design & Engineering,
Год журнала:
2024,
Номер
9(11), С. 1085 - 1106
Опубликована: Янв. 1, 2024
Porous
nanostructures
exhibit
remarkable
nanoplatforms
for
payload
delivery
to
diseased
cells
with
high
loading
capacity,
favorable
release
profiles,
improved
hemocompatibility,
biocompatibility,
and
safe
clearance
after
biodegradation.
Язык: Английский
Photosensitizable ZIF-8 BioMOF for Stimuli-Responsive Antimicrobial Phototherapy
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Resistant
pathogens
are
increasingly
posing
a
heightened
risk
to
healthcare
systems,
leading
growing
concern
due
the
lack
of
effective
antimicrobial
treatments.
This
has
prompted
adoption
photodynamic
therapy
(aPDT),
which
eradicates
microorganisms
by
generating
reactive
oxygen
species
(ROS)
through
utilization
photosensitizer,
photons,
and
molecular
oxygen.
However,
challenge
arises
from
inherent
characteristics
photosensitizers,
including
photobleaching,
aggregation,
self-quenching.
Consequently,
strategy
been
devised
adsorb
or
bind
photosensitizers
diverse
carriers
facilitate
their
delivery.
Notably,
metal–organic
frameworks
(MOFs)
have
emerged
as
promising
means
transporting
even
though
achieving
uniform
particle
sizes
room-temperature
synthesis
remains
complex
task.
In
this
work,
we
tackled
issue
heterogeneous
size
distribution
in
MOFs,
150
±
50
nm.
Subsequently,
harnessed
Zeolite
Imidazolate
Framework
8
(ZIF-8),
an
excellent
subclass
biocompatible
MOF,
effectively
load
two
distinct
categories
namely,
Rose
Bengal
(RB)
porphyrin,
using
simple,
straightforward,
single-step
process.
Our
findings
indicate
that
prepared
RB@ZIF-8
generates
more
substantial
amount
singlet
when
subjected
photoirradiation
(using
green
light-emitting
diode
(LED))
at
low
concentrations,
comparison
with
porphyrin@ZIF-8,
demonstrated
vitro
experiments.
Additionally,
investigated
pH-responsive
behavior
ascertain
its
implications
under
biological
conditions.
Correspondingly,
exhibited
favorable
IC50
value
against
Escherichia
coli
compared
bare
ZIF-8
alone,
other
photosensitizer-loaded
complexes.
underscores
potential
BioMOF
for
combatting
multidrug-resistant
bacteria
across
spectrum
infection
scenarios,
complemented
responsiveness
stimuli.
Язык: Английский
Bacterial Bioaerosol-Specific Capture and In Situ Detection Using an Immune ZIF-8-Melamine Foam-Functionalized Colorimetric Biosensor
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Bioaerosol
infections
containing
pathogenic
viruses
and
bacteria
have
resulted
in
significant
economic
losses
posed
a
serious
threat
to
public
health,
as
evidenced
by
outbreaks
of
coronavirus
disease
avian
influenza.
Consequently,
the
sampling
screening
bioaerosols
are
crucial
for
prevention
bioaerosol-borne
diseases.
In
this
study,
an
ultrasensitive
biosensor
based
on
zeolitic
imidazolate
framework-8-melamine
foam
(ZIF-8-MF)
was
innovatively
developed
specific
capture
situ
detection
bioaerosols.
The
bacterial
were
collected
wet
cyclone
into
phosphate-buffered
saline
(PBS)
buffer
at
high
collection
rate,
achieving
satisfactory
efficiency
∼80%
within
10
min.
target
PBS
specifically
captured
effectively
concentrated
using
immune
ZIF-8-MF.
gold@platinum
nanozymes
(GPNs)
employed
label
efficiently
amplify
biological
signal.
And
resulting
colorimetric
signal
analyzed
via
self-developed
smartphone
application
(App).
This
demonstrated
capability
detect
Salmonella
typhimurium
range
1.6
×
102-1.6
105
CFU/m3
1.5
h,
with
limit
low
100
CFU/m3.
Compared
other
bioaerosol
methods,
offered
advantages
such
capture,
efficient
concentration,
detection,
positioning
it
highly
promising
practical
tool
monitoring
diverse
bacteria.
Язык: Английский
Experimental and modeling study of 6FDA-Durene polyimide/ionic liquid-modified ZIF-8 mixed matrix membranes for CO2 separation
Results in Engineering,
Год журнала:
2025,
Номер
26, С. 104686 - 104686
Опубликована: Март 26, 2025
Язык: Английский
Advancements in chitosan-based nanocomposites with ZIF-8 nanoparticles: multifunctional platforms for wound healing applications
Carbohydrate Polymers,
Год журнала:
2025,
Номер
unknown, С. 123656 - 123656
Опубликована: Апрель 1, 2025
Язык: Английский
Two-dimensional metal-organic framework nanoleaf embedded with nitrogen-doped carbon dots for monitoring of picric acid
Microchemical Journal,
Год журнала:
2024,
Номер
206, С. 111616 - 111616
Опубликована: Сен. 10, 2024
Язык: Английский
Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5291 - 5291
Опубликована: Ноя. 8, 2024
This
study
reports
the
successful
synthesis
of
core-shell
microparticles
utilizing
coaxial
electrospray
techniques,
with
zeolitic
imidazolate
framework-8
(ZIF-8)
encapsulating
rhodamine
B
(RhB)
in
core
and
a
phase
change
material
(PCM)
shell
composed
eutectic
mixture
lauric
acid
(LA)
stearic
(SA).
ZIF-8
is
well-recognized
for
its
pH-responsive
degradation
biocompatibility,
making
it
an
ideal
candidate
targeted
drug
delivery.
The
LA-SA
PCM
mixture,
melting
point
near
physiological
temperature
(39
°C),
enables
temperature-triggered
release,
enhancing
therapeutic
precision.
structural
properties
were
extensively
characterized
through
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
differential
calorimetry
(DSC),
thermogravimetric
analysis
(TGA).
Drug
release
studies
revealed
dual-stimuli
response,
where
RhB
was
significantly
influenced
by
both
pH.
Under
mildly
acidic
conditions
(pH
4.0)
at
40
°C,
rapid
complete
observed
within
120
h,
while
37
rate
notably
slower.
Specifically,
°C
79%
higher
than
confirming
sensitivity
system.
Moreover,
pH
(7.4),
minimal
occurred,
demonstrating
system's
potential
minimizing
premature
under
neutral
conditions.
approach
holds
promise
improving
outcomes
cancer
treatment
enabling
precise
control
over
response
to
localized
hyperthermia,
reducing
off-target
effects
patient
compliance.
Язык: Английский
In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis
Materials Science-Poland,
Год журнала:
2024,
Номер
42(2), С. 41 - 51
Опубликована: Июнь 1, 2024
Abstract
Background
Osteoarthritis
(OA)
poses
a
significant
healthcare
challenge
globally,
necessitating
the
development
of
effective
therapeutic
interventions.
It
is
crucial
to
develop
novel
drug
delivery
systems
for
OA
treatment.
Aims
This
study
explores
potential
propolis,
saffron
extract,
and
curcumin-loaded
zeolitic
imidazolate
framework-8
(ZIF8)
nanoparticles
as
treatment
modality
OA.
The
anti-inflammatory
chondroprotective
properties
these
natural
compounds
make
them
promising
candidates
management.
Methods
Through
comprehensive
in
vitro
investigations,
including
scanning
electron
microscopy
(SEM),
MTT
assays,
antiinflammatory
cell
migration
Fourier
transform
infrared
(FTIR)
spectroscopy,
release
we
evaluated
physicochemical
biological
characteristics
ZIF8
nanocarriers.
Results
Our
findings
demonstrate
that
nanocarriers
effectively
encapsulated
bioactive
compounds,
exhibited
sustained
profiles,
displayed
properties.
Notably,
propolis-loaded
superior
activity
compared
other
formulations.
encapsulation
curcumin
within
holds
promise
enhancing
their
efficacy
ensuring
targeted
affected
joints
Conclusion
highlights
nanotechnology-based
harnessing
benefits
Язык: Английский