International Journal of Polymeric Materials, Год журнала: 2025, Номер unknown, С. 1 - 24
Опубликована: Апрель 22, 2025
Язык: Английский
European Polymer Journal, Год журнала: 2024, Номер 215, С. 113251 - 113251
Опубликована: Июнь 19, 2024
Meeting the escalating demands in biomedical applications has spurred creation of diverse scaffolds, where selection materials and manufacturing techniques stands as a linchpin fostering bone tissue formation. These scaffolds provide fundamental structural framework that supports cell growth differentiation. It is vital for repair, addressing various biological requisites such biocompatibility, biodegradability, mechanical properties becomes imperative. This comprehensive review discusses recent advancements 3D tailored specifically engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, bioprinting (including laser-based, inkjet extrusion bioprinting) are meticulously explored. Focusing on their respective applications, limitations, well advantages disadvantages within context regeneration. Furthermore, article underscores pivotal role material potential solution to address challenges associated with grafts. emphasizes need nuanced understanding significant considerations regardless type when designing or evaluating suitability integration into expansive realm engineering.
Язык: Английский
Процитировано
19
Med-X, Год журнала: 2025, Номер 3(1)
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
2
Gels, Год журнала: 2025, Номер 11(2), С. 88 - 88
Опубликована: Янв. 23, 2025
There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 138 - 174
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140855 - 140855
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12766 - 12766
Опубликована: Ноя. 27, 2024
Bone defects and fractures present significant clinical challenges, particularly in orthopedic maxillofacial applications. While minor bone may be capable of healing naturally, those a critical size necessitate intervention through the use implants or grafts. The utilization traditional methodologies, encompassing autografts allografts, is constrained by several factors. These include potential for donor site morbidity, restricted availability suitable donors, possibility immune rejection. This has prompted extensive research field tissue engineering to develop advanced synthetic bio-derived materials that can support regeneration. optimal substitute must achieve balance between biocompatibility, bioresorbability, osteoconductivity, osteoinductivity while simultaneously providing mechanical during process. Recent innovations three-dimensional printing, nanotechnology, bioactive coatings create scaffolds mimic structure natural enhance cell proliferation differentiation. Notwithstanding advancements above, challenges remain optimizing controlled release growth factors adapting various contexts. review provides comprehensive overview current materials, focusing on their biological mechanisms, design considerations, It explores role emerging technologies, such as additive manufacturing stem cell-based therapies, advancing field. Future highlights need multidisciplinary collaboration rigorous testing graft substitutes, improving outcomes quality life patients with complex defects.
Язык: Английский
Процитировано
5
Cells, Год журнала: 2024, Номер 13(12), С. 1065 - 1065
Опубликована: Июнь 19, 2024
Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells targeted 3D scaffolds have been investigated in the search for workable solutions. The use of cell-assisted regeneration is a crucial component engineering techniques designed overcome drawbacks grafts. This study provides detailed review scaffold applications with dentistry. focuses on while covering broad range studies explaining dentistry through presentation conducted this field. role different regenerative medicine covered great detail reviewed literature. These addressed wide subjects, including effects platelet concentrates during surgery specific combinations, such as human pulp animal model regeneration, promote models. Noting developments, research works consider methods improve vascularization explore 3D-printed scaffolds, secretome applications, mesenchymal cells, biomaterials regeneration. thorough assessment outlines possible developments these cycles insights suggestions additional study. Furthermore, alternative creative regenerating include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser nutritional supplements diet, gene biomimetic materials. innovative offer promising avenues future development
Язык: Английский
Процитировано
4
Virtual and Physical Prototyping, Год журнала: 2024, Номер 19(1)
Опубликована: Ноя. 4, 2024
3D bioprinting is at the forefront of tissue engineering to fabricate complex constructs resembling functional tissues. However, inability produce heterogeneous tissues and lack spatio-temporal control over release bioactive factors are greatly limiting clinical translation. Herein, combination with high-throughput dispensing using a custom microfluidic system nanoclay-based inks presented. This approach was found enhance printability, retention, controlled factors. Advanced models were developed resemble cancer skeletal tissue, while studying effect anti-cancer (Doxorubicin) pro-osteogenic growth (bone morphogenetic protein-2, BMP-2), respectively. The new nanoclay ink allowed sustained release, making it suitable for long-term applications. These findings suggest that by combining delivery platform can be assembled, offering significant advancements in regenerative medicine.
Язык: Английский
Процитировано
4
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101342 - 101342
Опубликована: Ноя. 14, 2024
Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.
Язык: Английский
Процитировано
4
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Bone fractures, especially large and complex defects, continue to pose significant challenges in the medical field. Current treatments often rely on autografts or allografts for structural support, which can lead problems such as reduced bioactivity, infection risks, potential pathogen transmission. Nature herbal medicine (NHM), including herbs extracts, offers a promising alternative by effectively modulating inflammatory responses, enhancing osteoblast function, inhibiting bone resorption, thereby facilitating fracture repair. However, traditional drug delivery methods NHM encounter interactions, poor tissue distribution, patient compliance. Biomaterials, engineered interact with biological systems, play essential roles repair, mechanical delivery. When used carriers, biomaterials be combined form stable systems that further promote regeneration. Here applications of are reviewed, hydrogels, extracellular vesicles, cement, conjunction regulating homeostasis aiming provide valuable insights guidance future research therapeutic strategies.
Язык: Английский
Процитировано
0