Exploring metal-organic frameworks (MOFs) in drug delivery: A concise overview of synthesis approaches, versatile applications, and current challenges
Applied Materials Today,
Год журнала:
2024,
Номер
41, С. 102443 - 102443
Опубликована: Сен. 21, 2024
Язык: Английский
Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems
Molecules,
Год журнала:
2025,
Номер
30(4), С. 884 - 884
Опубликована: Фев. 14, 2025
Researchers
have
extensively
investigated
photosensitizer
(PS)
derivatives
for
various
applications
due
to
their
superior
photophysical
and
electrochemical
properties.
However,
inherent
problems,
such
as
instability
self-quenching
under
physiological
conditions,
limit
biological
applications.
Metal-organic
frameworks
(MOFs)
covalent
organic
(COFs)
represent
two
relatively
new
material
types.
These
materials
high
surface
areas
permanent
porosity,
they
show
a
tremendous
deal
of
potential
like
these.
This
review
summarizes
key
synthesis
processes
highlights
recent
advancements
in
integrating
PS-based
COF
MOF
nanocarriers
biomedical
while
addressing
obstacles
prospects.
Язык: Английский
Advances in metal-organic framework-based drug delivery systems
M T Khulood,
U. S. Jijith,
Punnoth Poonkuzhi Naseef
и другие.
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125380 - 125380
Опубликована: Фев. 1, 2025
Язык: Английский
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(4), С. 114 - 114
Опубликована: Март 24, 2025
Cancer
significantly
impacts
human
quality
of
life
and
expectancy,
with
an
estimated
20
million
new
cases
10
cancer-related
deaths
worldwide
every
year.
Standard
treatments
including
chemotherapy,
radiotherapy,
surgical
removal,
for
aggressive
cancers,
such
as
glioblastoma,
are
often
ineffective
in
late
stages.
Glioblastoma,
example,
is
known
its
poor
prognosis
post-diagnosis,
a
median
survival
time
approximately
15
months.
Novel
therapies
using
local
electric
fields
have
shown
anti-tumour
effects
glioblastoma
by
disrupting
mitotic
spindle
assembly
inhibiting
cell
growth.
However,
constant
application
poses
risks
like
patient
burns.
Wireless
stimulation
via
piezoelectric
nanomaterials
offers
safer
alternative,
requiring
ultrasound
activation
to
induce
therapeutic
effects,
altering
voltage-gated
ion
channel
conductance
depolarising
membrane
potentials.
This
review
highlights
the
mechanism,
drug
delivery,
activation,
current
technologies
cancer
therapy,
emphasising
need
further
research
address
limitations
biocompatibility
whole
systems.
The
goal
underscore
these
areas
inspire
avenues
overcome
barriers
developing
nanoparticle-based
therapies.
Язык: Английский
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment
Medical Oncology,
Год журнала:
2024,
Номер
42(1)
Опубликована: Дек. 9, 2024
Язык: Английский
Carboxylate embedded metal organic frameworks for potential applications in drug delivery and controlled release
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
538, С. 216688 - 216688
Опубликована: Апрель 21, 2025
Язык: Английский
Improving the Effectiveness of Anticancer Properties of Capecitabine using Aminocaproic Acid-Hyaluronic Acid/Sulfonamide IR-MOF Nanoplatform for Colon Cancer Treatment
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2025,
Номер
unknown, С. 100827 - 100827
Опубликована: Май 1, 2025
Язык: Английский
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach
Toxicology Research,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 31, 2024
Abstract
Since
the
Industrial
Revolution,
ecological
damage,
ecosystem
disruption,
and
climate
change
acceleration
have
frequently
resulted
from
human
advancement
at
price
of
environment.
Due
to
rise
in
illnesses,
Industry
6.0
calls
for
a
renewed
dedication
sustainability
with
latest
technologies.
Focused
research
creative
solutions
are
needed
achieve
UN
Sustainable
Development
Goals
(SDGs),
especially
3,
9,
13,
14,
15,
17.
A
promising
sustainable
technology
enhancing
healthcare
while
reducing
environmental
effect
is
Metal
Organic
Frameworks
(MOFs).
MOFs
perfect
drug
administration
because
their
high
surface
areas,
adjustable
pore
sizes,
remarkable
drug-loading
capacities.
They
created
by
combining
advanced
artificial
intelligence,
intelligent
manufacturing,
quantum
computing.
Researchers
can
create
functional
groups
or
ligands
that
bind
selectively
target
cells
tissues,
minimizing
off-target
effects,
thanks
distinct
benefits
families
like
MIL,
HKUST,
UiO,
ZIF
etc.
offer
targeted
delivery.
Combining
other
nanomaterials
results
multipurpose
systems
handle
challenging
biomedical
issues.
Despite
its
promise,
there
still
issues
MOFs’
possible
toxicity
long-term
stability
physiological
settings.
To
advance
medicinal
applications,
these
problems
must
be
resolved.
increase
usefulness
medicine
critically
analysing
limitations
putting
up
alternatives.
The
creation
technologies
(additive
manufacturing
etc.)
delivery
prime
example
how
scientific
stewardship
may
coexist
provide
advantageous
both
people
Язык: Английский