Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Language: Английский

Exploring metal-organic frameworks (MOFs) in drug delivery: A concise overview of synthesis approaches, versatile applications, and current challenges DOI

Akash Vikal,

Rashmi Maurya, Preeti Patel

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102443 - 102443

Published: Sept. 21, 2024

Language: Английский

Citations

20
Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems DOI Creative Commons

Aviwe Magadla

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 884 - 884

Published: Feb. 14, 2025

Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability self-quenching under physiological conditions, limit biological applications. Metal-organic frameworks (MOFs) covalent organic (COFs) represent two relatively new material types. These materials high surface areas permanent porosity, they show a tremendous deal of potential like these. This review summarizes key synthesis processes highlights recent advancements in integrating PS-based COF MOF nanocarriers biomedical while addressing obstacles prospects.

Language: Английский

Citations

1
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment DOI
Zainab Lafi, Sina M. Matalqah,

Ebaa Abu-Saleem

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 9, 2024

Language: Английский

Citations

4
Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

Citations

0
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma DOI Creative Commons

Zayne Knight,

Amalia Ruiz, Jacobo Elíes

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 114 - 114

Published: March 24, 2025

Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.

Language: Английский

Citations

0
Carboxylate embedded metal organic frameworks for potential applications in drug delivery and controlled release DOI
Hazrat Bilal,

Sana Zahoor,

M. Iqbal Choudhary

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216688 - 216688

Published: April 21, 2025

Language: Английский

Citations

0
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Language: Английский

Citations

0