Therapeutic Efficacy of Helianthemum lippii Extract and Silver Nanoparticles Synthesized from the Extract against Cadmium-Induced Renal Nephrotoxicity in Wistar Rats
Ibtissam Laib,
Boutlilis Djahra Ali,
Ali Alsalme
и другие.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(8), С. 982 - 982
Опубликована: Июль 25, 2024
This
study
explored
the
therapeutic
efficacy
of
Язык: Английский
Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Язык: Английский
Ciprofloxacin-loaded copper oxide nanoparticles: Cutting-edge multifunctional nano-therapeutics with superior antidiabetic, antioxidant, anti-inflammatory, and antibacterial potency against drug-resistant pathogens
Journal of Crystal Growth,
Год журнала:
2025,
Номер
unknown, С. 128074 - 128074
Опубликована: Янв. 1, 2025
Язык: Английский
Understanding the silver nanotoxicity: mechanisms, risks, and mitigation strategies
Journal of Nanoparticle Research,
Год журнала:
2025,
Номер
27(4)
Опубликована: Март 25, 2025
Язык: Английский
De novo transcriptome assembly of the plant Helianthemum marifolium for the study of adaptive mechanisms
Scientific Data,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 27, 2025
The
genus
Helianthemum,
commonly
known
as
rockroses,
encompasses
140
species
primarily
distributed
in
the
Palearctic
region,
with
notable
diversification
driven
by
climatic
and
geological
changes.
These
plants
are
valuable
for
studying
speciation
processes
ecological
divergence.
chemical
properties
of
leaves
have
also
been
investigated
containing
bioactive
compounds
several
therapeutic
properties.
However,
availability
genomic
resources
this
almost
entirely
lacking.
Here,
we
assembled
annotated
first
reference
transcriptome
Helianthemum
marifolium,
a
wide
morphological
variability
infraspecific
diversity.
Illumina
paired-end
RNA
sequences
were
generated
using
from
16
individuals,
representing
four
recognized
subspecies,
all
cultivated
greenhouse.
reads
Trinity
Oases,
EvidentialGene
produced
122,002
transcripts.
showed
59524
hits
on
UniProtBK
database
through
BLASTx.
This
will
be
an
invaluable
resource
transcriptome-level
population
studies,
conservation
genetics
many
endangered
within
genus,
deepen
into
metabolic
pathways
leaf-derived
compounds.
Язык: Английский
Phytochemical profiling and fractionation of Helianthemum lippii extract versus silver nanoparticle-modified extract: assessment of photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 10, 2024
This
study
investigates
the
synthesis
of
silver
nanoparticles
(Ag
NPs)
using
Helianthemum
lippii
extract
and
evaluates
their
photoprotective,
anti-hemolytic,
antibacterial,
anti-inflammatory
properties
compared
to
various
fractions,
including
total
aqueous
(AE),
flavonoid
monoglycosides
(FMG),
diglycosides/triglycosides
(FDG/FTG),
tannins
(TN),
anthocyanins
(AC).
is
rich
in
bioactive
compounds
such
as
caffeic
acid,
p-coumaric
gallic
known
for
therapeutic
potential.
aims
determine
whether
embedding
these
phytochemicals
into
Ag
NPs
enhances
biomedical
applications
natural
fractions.
were
synthesized
through
a
green
approach,
physicochemical
properties,
size
morphology,
characterized.
High-performance
liquid
chromatography
(HPLC)
was
used
identify
key
Biological
assays
conducted
assess
photoprotective
efficacy
(sun
protection
factor,
SPF),
antibacterial
activity
(minimum
inhibitory
concentration,
MIC),
potential
(percentage
inhibition),
hemolytic
with
sodium
dodecyl
sulfate
(SDS)
serving
control.
HPLC
analysis
confirmed
presence
compounds,
AE
extract.
The
spherical
an
average
diameter
35
nm
had
adsorbed
on
surface.
AC
fraction
demonstrated
highest
SPF
(28.27),
followed
by
TN
(27.99),
(23.20),
(22.50),
while
FMG
exhibited
moderate
(19.39)
commercial
sunscreen
Avene®
(40.00).
superior
MIC
values
0.2
mg/mL
against
Pseudomonas
aeruginosa
0.4
Bacillus
subtilis,
outperforming
AE,
which
2.81
mg/mL.
Anti-inflammatory
showed
that
achieved
79.8%
inhibition
at
400
μg/mL,
surpassing
(71.75%)
(67.9%),
comparable
diclofenac
(72.63%).
Hemolysis
revealed
induced
only
1.35%
hemolysis,
lower
than
(1.91%)
significantly
below
SDS
(90.48%).
findings
demonstrate
lippii-derived
exhibit
enhanced
anti-inflammatory,
anti-hemolytic
While
slightly
multifunctional
bioactivities
underscore
applications.
integration
efficacy,
making
them
promising
candidates
advanced
pharmaceutical
formulations
topical
protective
agents.
Язык: Английский
Therapeutic Efficacy of Salvia chudaei Ethanol Extract in Hyperlipidemia, Hyperglycemia, and Oxidative Stress in Triton X‐100‐Induced Wistar Rats
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
ABSTRACT
The
study
explored
the
efficacy
of
Salvia
chudaei
ethanolic
extract
in
managing
hyperlipidemia,
hyperglycemia,
and
oxidative
stress
induced
by
Triton
X‐100
Wistar
rats.
Twenty‐four
rats
were
divided
into
four
groups:
Control,
S.
‐treated,
Triton‐induced
hyperlipidemic,
a
combination
+
treatment.
raised
serum
levels
total
cholesterol,
triacylglycerol,
low‐density
lipoprotein
(LDL)
while
lowering
high‐density
(HDL)
leading
to
marked
increased
malondialdehyde
(MDA)
reduced
antioxidant
activity
liver
kidney
tissues.
Administration
effectively
reversed
these
adverse
effects,
significantly
LDL
levels,
improving
HDL
cholesterol.
It
also
enhanced
defenses
markers,
demonstrating
its
protective
role
against
metabolic
dysfunction.
High‐performance
liquid
chromatography
analysis
confirmed
presence
bioactive
compounds
that
contribute
benefits.
findings
suggest
possesses
strong
antihyperlipidemic,
antihyperglycemic,
properties,
making
it
promising
natural
agent
for
preventing
treating
hyperlipidemia
stress.
This
positions
as
potential
new
therapeutic
approach
management
disorders.
Язык: Английский
Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 23, 2024
Background
Silver
nanoparticles
(Ag/Ag₂O
NPs)
have
garnered
attention
for
their
potent
antioxidant,
antimicrobial,
and
anti-inflammatory
properties,
showing
promise
therapeutic
applications,
particularly
in
mitigating
chemical-induced
toxicity.
Objective
This
study
aimed
to
synthesize
Ag/Ag₂O
NPs
using
Olea
europaea
(olive)
leaf
extract
as
a
green,
eco-friendly
reducing
agent
evaluate
protective
effects
against
metribuzin-induced
toxicity
Wistar
rats,
focusing
on
oxidative
stress,
hematological
parameters,
lipid
profiles,
with
specific
dose
optimization.
Methodology
were
synthesized
extract,
properties
confirmed
via
XRD,
FTIR,
SEM,
EDS,
UV-visible
spectroscopy.
rats
exposed
metribuzin
(110
mg/kg/day)
treated
two
doses
of
(0.062
mg/kg
0.125
mg/kg).
Hematological
biochemical
markers
assessed
the
NPs’
effects.
Results
Physicochemical
characterization
successful
formation
loaded
phytochemicals,
exhibiting
crystallite
sizes
23
nm
19
nm,
particle
size
25
significant
peaks
UV-Vis
spectra
indicating
Ag/Ag₂O.
Metribuzin
exposure
led
disruptions
(elevated
WBC,
reduced
RBC
hemoglobin)
worsened
profiles
(increased
cholesterol,
LDL,
triglycerides).
The
lower
NP
mg/kg)
improved
RBC,
hemoglobin,
platelet
counts,
normalized
levels,
positively
influenced
such
serum
creatinine
uric
acid.
In
contrast,
higher
(0.125
showed
mixed
results,
some
improvements
but
an
increase
triglycerides
continued
elevation
ASAT
ALAT
enzyme
levels.
Conclusion
green
methods
olive
effectively
mitigated
toxicity,
especially
at
doses,
by
improving
stress
profiles.
Dose
optimization
is
crucial
maximize
benefits
minimize
adverse
effects,
underscoring
potential
treating
Язык: Английский