LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113609 - 113609

Опубликована: Авг. 27, 2022

Epigenetic factors are critical regulators of biological and pathological mechanisms they could interact with different molecular pathways. Targeting epigenetic has been an idea approach in disease therapy, especially cancer. Accumulating evidence highlighted function long non-coding RNAs (lncRNAs) as cancer initiation development focused on their association downstream targets. microRNAs (miRNAs) the most well-known targets lncRNAs present review focuses lncRNA-miRNA axis malignancy therapy resistance tumors. LncRNA-miRNA regulates cell death such apoptosis autophagy cancers. This affects tumor metastasis via regulating EMT MMPs. Besides, determines sensitivity cells to chemotherapy, radiotherapy immunotherapy. Based studies, can be affected by drugs genetic tools this may affect expression level miRNAs targets, leading suppression/progression. LncRNAs have both tumor-promoting tumor-suppressor functions unique complicated implication therapy. also other signaling networks PI3K/Akt, STAT3, Wnt/β-catenin EZH2 among others. Notably, lncRNA/miRNA considered a signature for diagnosis prognosis

Язык: Английский

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LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC

Journal of Ovarian Research, Год журнала: 2023, Номер 16(1)

Опубликована: Фев. 18, 2023

Premature ovarian insufficiency (POI) is one of the common women reproductive endocrine diseases which adversely impacts female fertility, but etiology and pathogenesis still remain elusive. Recently increasing researches focus on roles lncRNA in POI. LncRNA DANCR was involved cell differentiation multiple cancers. It's highly expressed ovary while role POI unknown.Here, we identify a new related DANCR, negatively contributes to granulosa cells aging follicular atresia. proved be decreasingly patients' cells. Additionally, Dancr knockout (Dancr-/-) mice were constructed characterized with phenotypes fertility decline, compared Dancr+/+ mice. Further, vitro experiments indicated that knockdown led series aging-related changes including proliferation inhibition, cycle G1 arrest DNA damage. Mechanism research revealed binds hNRNPC p53, attenuates binding thus enhancing protein level p53 promoting significantly.The newly identified inhibits p53-dependent by regulating hNRNPC-p53 interaction, eventually counteracting This provides insights into potential target for future diagnosis treatment.

Язык: Английский

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lncRNA-mediated ceRNA network in bladder cancer

Non-coding RNA Research, Год журнала: 2022, Номер 8(2), С. 135 - 145

Опубликована: Дек. 14, 2022

Bladder cancer is a common disease associated with high rates of morbidity and mortality. Although immunotherapy approaches such as adoptive T-cell therapy immune checkpoint blockade have been investigated for the treatment bladder cancer, their off-target effects ability to affect only single targets led clinical outcomes that are far from satisfactory. Therefore, it important identify novel can effectively control tumor growth metastasis. It well known long noncoding RNAs (lncRNAs) powerful regulators gene expression. Increasing evidence has shown dysregulated lncRNAs in involved cell proliferation, migration, invasion, apoptosis, epithelial-mesenchymal transition (EMT). In this review, we focus on roles underlying mechanisms lncRNA-mediated competing endogenous RNA (ceRNA) networks regulation progression. addition, discuss potential targeting ceRNA overcome resistance its association clinicopathological features patients. We hope review will stimulate research develop more effective therapeutic treatment.

Язык: Английский

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Tumor‐derived exosome ElNF1‐AS1 affects the progression of gastric cancer by promoting M2 polarization of macrophages

Environmental Toxicology, Год журнала: 2023, Номер 38(9), С. 2228 - 2239

Опубликована: Июнь 13, 2023

Abstract Background This study attempted to investigate the role of exosome ELFN1‐AS1 in gastric cancer (GC). Methods The used various techniques determine level exosomal GC tissue and cells, including quantitative real‐time PCR . Pull‐down assay dual‐luciferase reporter were employed identify interactions between miR‐4644, as well miR‐4644 PKM. Western blot was explore potential regulatory mechanism. Several vitro assays conducted xenograft models impacts on development, metastasis macrophage polarization. Results upregulated with high enrichment GC‐derived exosomes. Exosomal enhances cell abilities stemness GC. targeted regulated which triggered PKM expression. modulated glycolysis via an HIF‐1α dependent manner GC, promoting M2 polarization recruitment. Furthermore, enhanced growth, vivo. Conclusions suggests that could be a promising biomarker for diagnosis treatment

Язык: Английский

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Molecular and Therapeutic Roles of Non-Coding RNAs in Oral Cancer—A Review

Molecules, Год журнала: 2024, Номер 29(10), С. 2402 - 2402

Опубликована: Май 20, 2024

Oral cancer (OC) is among the most common malignancies in world. Despite advances therapy, worst-case scenario for OC remains metastasis, with a 50% survival rate. Therefore, it critical to comprehend pathophysiology of condition and create diagnostic treatment plans OC. The development high-throughput genome sequencing has revealed that over 90% human encodes non-coding transcripts, or transcripts do not code any proteins. This paper describes function these different kinds RNAs (ncRNAs) as well their intriguing therapeutic potential. onset OC, resistance, are linked dysregulated ncRNA expression. These ncRNAs’ potentially significant roles diagnosis prognosis have been suggested by differing expression blood saliva. We outlined every promising feature ncRNAs this study.

Язык: Английский

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Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications

Cancers, Год журнала: 2023, Номер 15(15), С. 3752 - 3752

Опубликована: Июль 25, 2023

Oral cancer (OC) is among the most prevalent cancers in world. Certain geographical areas are disproportionately affected by OC cases due to regional differences dietary habits, tobacco and alcohol consumption. However, conventional therapeutic methods do not yield satisfying treatment outcomes. Thus, there an urgent need understand disease process develop diagnostic strategies for OC. In this review, we discuss role of various types ncRNAs OC, their promising clinical implications as prognostic or markers targets. MicroRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), PIWI-interacting (piRNA), small nucleolar (snoRNA) major whose involvement emerging. Dysregulated expression ncRNAs, particularly miRNAs, lncRNAs, circRNAs, linked with initiation, progression, well therapy resistance via modulation a series cellular pathways through epigenetic, transcriptional, post-transcriptional, translational modifications. Differential expressions miRNAs lncRNAs blood, saliva extracellular vesicles have indicated potential importance. summarized all aspects management

Язык: Английский

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IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia

APOPTOSIS, Год журнала: 2023, Номер 28(7-8), С. 1035 - 1047

Опубликована: Апрель 15, 2023

Abstract Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% AML patients. The expression DANCR in FLT3-ITD had not been paid attention to, and whether its regulatory relationship with IGF2BP2 can affect progression was unclear. Our study sought to verify biological role as an m6A reading protein AML. To further explore mechanism AML, provide a basis screening biomarkers development targeted drugs. results show that upregulated FLT3-ITD+ patients cells. Si-IGF2BP2 could inhibit proliferation, glycolytic promote apoptosis MV4-11 RNA stability. This discovery will new horizons early therapy

Язык: Английский

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The emerging landscape of small nucleolar RNA host gene 10 in cancer mechanistic insights and clinical relevance

Cellular Signalling, Год журнала: 2025, Номер 127, С. 111590 - 111590

Опубликована: Янв. 10, 2025

Язык: Английский

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The role of lncRNAs in the interplay of signaling pathways and epigenetic mechanisms in glioma

Epigenomics, Год журнала: 2025, Номер 17(2), С. 125 - 140

Опубликована: Янв. 19, 2025

Gliomas, highly aggressive tumors of the central nervous system, present overwhelming challenges due to their heterogeneity and therapeutic resistance. Glioblastoma multiforme (GBM), most malignant form, underscores this clinical urgency dismal prognosis despite treatment regimens. Recent advances in cancer research revealed signaling pathways epigenetic mechanisms that intricately govern glioma progression, offering multifaceted targets for intervention. This review explores dynamic interplay between events regulation context glioma, with a particular focus on crucial roles played by non-coding RNAs (ncRNAs). Through direct indirect targeting, ncRNAs emerge as key regulators shaping molecular landscape glioblastoma across its various stages. By dissecting these intricate regulatory networks, novel patient-tailored strategies could be devised improve patient outcomes devastating disease.

Язык: Английский

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Construction and validation of a prognostic model of lncRNAs associated with RNA methylation in lung adenocarcinoma

Translational Cancer Research, Год журнала: 2025, Номер 14(2), С. 761 - 777

Опубликована: Фев. 1, 2025

Lung adenocarcinoma (LUAD) is a common type of lung cancer and one the leading causes death worldwide. Long non-coding RNAs (lncRNAs) play crucial role in tumors. The purpose this study was to explore expression lncRNAs associated with RNA methylation modification their prognostic value LUAD. sequencing clinical data were downloaded from Cancer Genome Atlas dataset, messenger annotated by Ensemble. related regulators (RMlncRNAs) filtered Pearson correlation analysis between differentially expressed regulators. Univariate Cox regression analysis, multivariate least absolute shrinkage selection operator used construct model. receiver operating characteristic curve (ROC) plotted validate predictive Then, tumor mutational burden (TMB) microsatellite instability compare immunotherapy response. Finally, perform drug sensitivity half-maximal inhibitory concentration (IC50) targeted drugs calculated using pRRophetic package. In total, 18 RMlncRNAs prognosis LUAD patients identified. six feature (NFYC-AS1, OGFRP1, MIR4435-2HG, TDRKH-AS1, DANCR, TMPO-AS1) ROC curves for training, testing, validation sets showed that model effective. subindex based on had high TMB. high-risk group might be subject greater immune resistance according comparison Tumor Immune Dysfunction Exclusion scores. IC50 11 differences high- low-risk group, only three drug's target genes (ERBB4, CASP8, CD86) expressed. conclusion, constructed bioinformatics which provide new insight into evaluation treatment

Язык: Английский

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