Complex housing partially mitigates low dose radiation-induced changes in brain and behavior in rats DOI

Anna Fiselier,

Richelle Mychasiuk,

Arif Muhammad

и другие.

Restorative Neurology and Neuroscience, Год журнала: 2022, Номер 40(2), С. 109 - 124

Опубликована: Апрель 30, 2022

Purpose: In recent years, much effort has been focused on developing new strategies for the prevention and mitigation of adverse radiation effects healthy tissues organs, including brain. The brain is very sensitive to effects, albeit as it highly plastic. Hence, deleterious may be potentially reversible. Because exposure affects dendritic space, reduces brain’s ability produce neurons, alters behavior, efforts should focus restoring these parameters. To that effect, environmental enrichment through complex housing (CH) exercise provide a plausible avenue exploration protection from irradiation. CH broader concept than alone, constitutes animals positive physical social stimulation superior their routine care conditions. We hypothesized CHs lessen harmful neuroanatomical behavioural low dose exposure. Methods: analyzed compared cerebral morphology in exposed head, bystander (liver), scatter irradiation rats housed either condos or standard housing. Results: Enriched condo conditions ameliorated radiation-induced changes. Moreover, irradiated were kept enriched displayed fewer deficits those Conclusions: Animal model-based strategies, such CH, are excellent surrogate models occupational therapy humans, consequently have significant translational possibility. Our study thus serve roadmap development new, easy, safe cost-effective methods prevent mitigate low-dose

Язык: Английский

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting DOI Creative Commons
Mahmoud Al‐Azab,

Mohammed Safi,

Elina Idiiatullina

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2022, Номер 27(1)

Опубликована: Авг. 19, 2022

Human mesenchymal stem cells (MSCs) are primary multipotent capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role MSCs in tissue homeostasis, aging-related diseases, cellular therapy is clinically suggested. As aging a universal problem that has large socioeconomic effects, an improved understanding the concepts can direct public policies reduce its adverse impacts on healthcare system humanity. Several studies have been carried out over several years to understand phenomenon different factors affecting human aging. A reduced ability adult cell populations reproduce regenerate one main contributors process. In this context, senescence major challenge front advancement. Many factors, ranging from genetic metabolic pathways extrinsic through various signaling pathways, involved regulating mechanism MSC senescence. To better reverse senescence, review highlights underlying mechanisms signs discusses strategies combat

Язык: Английский

Процитировано

100

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force? DOI Creative Commons
Jasmina Isaković,

Klara Šerer,

Barbara Barišić

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Фев. 28, 2023

Neurological disorders are recognized as major causes of death and disability worldwide. Because this, they represent one the largest public health challenges. With awareness massive burden associated with these disorders, came recognition that treatment options were disproportionately scarce and, oftentimes, ineffective. To address problems, modern research is increasingly looking into novel, more effective methods to treat neurological patients; which cell-based therapies. In this review, we present a critical analysis features, challenges, prospects stem cell types can be employed numerous disorders—mesenchymal cells (MSCs). Despite fact several studies have already established safety MSC-based approaches, there still some reservations within field regarding their immunocompatibility, heterogeneity, stemness stability, range adverse effects—one tumor-promoting ability. We additionally examine MSCs’ mechanisms action respect in vitro vivo well detail findings past ongoing clinical trials for Parkinson’s Alzheimer’s disease, ischemic stroke, glioblastoma multiforme, multiple sclerosis. Finally, review discusses therapeutics form biomaterials, use electromagnetic fields enhance proliferation differentiation neuronal cells.

Язык: Английский

Процитировано

27

Therapeutic role of neural stem cells in neurological diseases DOI Creative Commons
Ling Yang, Sicheng Liu, Yiyi Liu

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Март 7, 2024

The failure of endogenous repair is the main feature neurological diseases that cannot recover damaged tissue and resulting dysfunction. Currently, range treatment options for limited, approved drugs are used to treat diseases, but therapeutic effect still not ideal. In recent years, different studies have revealed neural stem cells (NSCs) made exciting achievements in diseases. NSCs potential self-renewal differentiation, which shows great foreground as replacement therapy broadens a new way cell therapy. biological functions nerve injury include neuroprotection, promoting axonal regeneration remyelination, secretion neurotrophic factors, immune regulation, improve inflammatory microenvironment injury. All these reveal play an important role improving progression Therefore, it significance better understand functional view this, we comprehensively discussed application value well existing problems challenges.

Язык: Английский

Процитировано

10

Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review DOI Creative Commons
Siddharth Shah, Hadeel M. Mansour, Brandon Lucke‐Wold

и другие.

Cells, Год журнала: 2025, Номер 14(1), С. 42 - 42

Опубликована: Янв. 3, 2025

Huntington’s disease (HD) is an inherited neurodegenerative characterized by uncontrolled movements, emotional disturbances, and progressive cognitive impairment. It estimated to affect 4.3 10.6 per 100,000 people worldwide, the mean prevalence rate among all published studies, reviews, genetic HD registries 5.7 100,000. A key feature of loss striatal neurons cortical atrophy. Although there no cure at present, discovery gene causing has brought us into a new DNA era therapeutic advances for several neurological disorders. PubMed was systematically searched using three search strings: ‘“Huntington disease” + “stem cell”’, ‘”Huntington Mesenchymal stromal cell’, “induced pluripotent stem cell”’. For each string, results were categorized based on cell type, papers that included clinical analysis as well. The data extracted up 2024. We did not include other databases in our have comparable systematic review literature topic. collected analyzed used critical interpretation present review. Data are presented chronologically studies published. Therapeutic strategies cells drawn lot interest possible therapies. Recent research indicates NSCs been most often utilized type treating HD. generated from variety sources, including patients’ somatic brain itself. There strong evidence supporting transplantation or their derivatives animal models, even if stem-cell-based preclinical trials still early stages. Current treatment only aims relieving symptoms rather than pathogenesis disease. models shown promise improving motor functions, therapy faces many challenges disadvantages immunosuppression immunorejection well ethical, technical, safety concerns. Further required definitive conclusion.

Язык: Английский

Процитировано

1

iPSCs in Neurodegenerative Disorders: A Unique Platform for Clinical Research and Personalized Medicine DOI Open Access
Shashank Pandey, Michal Jirásko, Jan Lochman

и другие.

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(9), С. 1485 - 1485

Опубликована: Сен. 10, 2022

In the past, several animal disease models were developed to study molecular mechanism of neurological diseases and discover new therapies, but lack equivalent has minimized success rate. A number critical issues remain unresolved, such as high costs for developing models, ethical issues, resemblance with human disease. Due poor initial screening assessment molecules, more than 90% drugs fail during final step clinical trial. To overcome these limitations, a approach been based on induced pluripotent stem cells (iPSCs). The discovery iPSCs provided roadmap translation research regeneration therapy. this article, we discuss potential role patient-derived in their contribution scientific future medicine. humaniPSCs most common neurodegenerative (e.g., Parkinson's Alzheimer's disease, diabetic neuropathy, stroke, spinal cord injury) examined ranked per published literature PUBMED. We have observed that scored highest, followed by Furthermore, also explored recent advancements field personalized medicine, patient-on-a-chip concept, where can be grown 3D matrices inside microfluidic devices create an vitro model

Язык: Английский

Процитировано

21

Circadian Interventions in Preclinical Models of Huntington’s Disease: A Narrative Review DOI Creative Commons

Derek Dell’Angelica,

Karan Singh, Christopher S. Colwell

и другие.

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1777 - 1777

Опубликована: Авг. 6, 2024

Huntington's Disease (HD) is a neurodegenerative disorder caused by an autosomal-dominant mutation in the huntingtin gene, which manifests with triad of motor, cognitive and psychiatric declines. Individuals HD often present disturbed sleep/wake cycles, but it still debated whether altered circadian rhythms are intrinsic to its aetiopathology or consequence. Conversely, well established that disturbances, perhaps acting concert other pathophysiological mechanisms, worsen impact disease on motor functions burden patients their caretakers. Currently, there no cure stop progression HD, however, preclinical research providing cementing evidence restoring fluctuation can assist delaying onset slowing HD. Here we highlight application circadian-based interventions models provide insights into potential translation clinical practice. Interventions aimed at improving cycles' synchronization have shown improve deficits models. Therefore, strong support for suitability ameliorate symptoms humans emerges from literature, albeit gaps our knowledge underlying mechanisms possible risks associated implementation.

Язык: Английский

Процитировано

4

Age-Related Neurodegenerative Diseases: A Stem Cell’s Perspective DOI Creative Commons
Belén Calvo, Pierre Schembri-Wismayer, María Beatriz Durán Alonso

и другие.

Cells, Год журнала: 2025, Номер 14(5), С. 347 - 347

Опубликована: Фев. 27, 2025

Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and concomitant decline in neurological function. Examples this type clinical condition are Alzheimer's Disease, Parkinson's Huntington's Disease Amyotrophic Lateral Sclerosis. Age has been identified as major risk the etiology these which explains their increased incidence developed countries. Unfortunately, despite continued intensive efforts, no cure yet found for any diseases; reliable markers that allow an early diagnosis disease identification key molecular events leading to onset progression lacking. Altered adult neurogenesis appears precede appearance severe symptoms. Given scarcity human samples considerable differences with model species, increasingly complex stem-cell-based models being developed. These shedding light on alterations contribute development, facilitating new targets providing screening platform testing candidate drugs. Moreover, secretome other promising features cell types explored, use them replacement cells high plasticity or co-adjuvant therapy combinatorial treatments.

Язык: Английский

Процитировано

0

Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases DOI Creative Commons
Haibin Shen, Jie Chen,

Meijin Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 2, 2025

As the world's population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to research of these illnesses, little progress has made in creation novel diagnostic therapeutic approaches. Extracellular vesicles (EVs) released by all cell types contain proteins, microRNAs, mRNAs, other biologically active molecules. EVs play an important role intercellular communication well regulation neuroinflammation. Determining mechanisms which contribute pathogenesis will aid development new approaches tools. Mesenchymal stem cells (MSCs) shown studies control immunological responses, promote growth brain connections, production blood vessels, heal damaged tissues. There is growing evidence that MSCs' ability treat patients mostly due neurotrophic compounds they secrete through EVs. Since their tiny size allows them pass biological barriers reach injured parts central nervous system, MSC-derived extracellular (MSC-EVs) retain qualities parent MSCs. This review discusses highlights potential MSC-EVs treatment diseases. The paper also examines challenges still need be overcome prospects for using illnesses.

Язык: Английский

Процитировано

0

Environmental enrichment: a neurostimulatory approach to aging and ischemic stroke recovery and rehabilitation DOI

Sijina Kinattingara Parambath,

Navami Krishna,

G. K. Rajanikant

и другие.

Biogerontology, Год журнала: 2025, Номер 26(3)

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0

Data-independent acquisition-based quantitative proteomic analysis of the effects of environmental enrichment on the dorsal roots of mice with neuropathic pain induced by ischiadicus nervus chronic constriction injury DOI

Jiacheng Pan,

Hua Lin, Jingyu Feng

и другие.

Neuropharmacology, Год журнала: 2025, Номер 275, С. 110481 - 110481

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0