Restorative Neurology and Neuroscience,
Год журнала:
2022,
Номер
40(2), С. 109 - 124
Опубликована: Апрель 30, 2022
Purpose:
In
recent
years,
much
effort
has
been
focused
on
developing
new
strategies
for
the
prevention
and
mitigation
of
adverse
radiation
effects
healthy
tissues
organs,
including
brain.
The
brain
is
very
sensitive
to
effects,
albeit
as
it
highly
plastic.
Hence,
deleterious
may
be
potentially
reversible.
Because
exposure
affects
dendritic
space,
reduces
brain’s
ability
produce
neurons,
alters
behavior,
efforts
should
focus
restoring
these
parameters.
To
that
effect,
environmental
enrichment
through
complex
housing
(CH)
exercise
provide
a
plausible
avenue
exploration
protection
from
irradiation.
CH
broader
concept
than
alone,
constitutes
animals
positive
physical
social
stimulation
superior
their
routine
care
conditions.
We
hypothesized
CHs
lessen
harmful
neuroanatomical
behavioural
low
dose
exposure.
Methods:
analyzed
compared
cerebral
morphology
in
exposed
head,
bystander
(liver),
scatter
irradiation
rats
housed
either
condos
or
standard
housing.
Results:
Enriched
condo
conditions
ameliorated
radiation-induced
changes.
Moreover,
irradiated
were
kept
enriched
displayed
fewer
deficits
those
Conclusions:
Animal
model-based
strategies,
such
CH,
are
excellent
surrogate
models
occupational
therapy
humans,
consequently
have
significant
translational
possibility.
Our
study
thus
serve
roadmap
development
new,
easy,
safe
cost-effective
methods
prevent
mitigate
low-dose
Cellular & Molecular Biology Letters,
Год журнала:
2022,
Номер
27(1)
Опубликована: Авг. 19, 2022
Human
mesenchymal
stem
cells
(MSCs)
are
primary
multipotent
capable
of
differentiating
into
osteocytes,
chondrocytes,
and
adipocytes
when
stimulated
under
appropriate
conditions.
The
role
MSCs
in
tissue
homeostasis,
aging-related
diseases,
cellular
therapy
is
clinically
suggested.
As
aging
a
universal
problem
that
has
large
socioeconomic
effects,
an
improved
understanding
the
concepts
can
direct
public
policies
reduce
its
adverse
impacts
on
healthcare
system
humanity.
Several
studies
have
been
carried
out
over
several
years
to
understand
phenomenon
different
factors
affecting
human
aging.
A
reduced
ability
adult
cell
populations
reproduce
regenerate
one
main
contributors
process.
In
this
context,
senescence
major
challenge
front
advancement.
Many
factors,
ranging
from
genetic
metabolic
pathways
extrinsic
through
various
signaling
pathways,
involved
regulating
mechanism
MSC
senescence.
To
better
reverse
senescence,
review
highlights
underlying
mechanisms
signs
discusses
strategies
combat
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 28, 2023
Neurological
disorders
are
recognized
as
major
causes
of
death
and
disability
worldwide.
Because
this,
they
represent
one
the
largest
public
health
challenges.
With
awareness
massive
burden
associated
with
these
disorders,
came
recognition
that
treatment
options
were
disproportionately
scarce
and,
oftentimes,
ineffective.
To
address
problems,
modern
research
is
increasingly
looking
into
novel,
more
effective
methods
to
treat
neurological
patients;
which
cell-based
therapies.
In
this
review,
we
present
a
critical
analysis
features,
challenges,
prospects
stem
cell
types
can
be
employed
numerous
disorders—mesenchymal
cells
(MSCs).
Despite
fact
several
studies
have
already
established
safety
MSC-based
approaches,
there
still
some
reservations
within
field
regarding
their
immunocompatibility,
heterogeneity,
stemness
stability,
range
adverse
effects—one
tumor-promoting
ability.
We
additionally
examine
MSCs’
mechanisms
action
respect
in
vitro
vivo
well
detail
findings
past
ongoing
clinical
trials
for
Parkinson’s
Alzheimer’s
disease,
ischemic
stroke,
glioblastoma
multiforme,
multiple
sclerosis.
Finally,
review
discusses
therapeutics
form
biomaterials,
use
electromagnetic
fields
enhance
proliferation
differentiation
neuronal
cells.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Март 7, 2024
The
failure
of
endogenous
repair
is
the
main
feature
neurological
diseases
that
cannot
recover
damaged
tissue
and
resulting
dysfunction.
Currently,
range
treatment
options
for
limited,
approved
drugs
are
used
to
treat
diseases,
but
therapeutic
effect
still
not
ideal.
In
recent
years,
different
studies
have
revealed
neural
stem
cells
(NSCs)
made
exciting
achievements
in
diseases.
NSCs
potential
self-renewal
differentiation,
which
shows
great
foreground
as
replacement
therapy
broadens
a
new
way
cell
therapy.
biological
functions
nerve
injury
include
neuroprotection,
promoting
axonal
regeneration
remyelination,
secretion
neurotrophic
factors,
immune
regulation,
improve
inflammatory
microenvironment
injury.
All
these
reveal
play
an
important
role
improving
progression
Therefore,
it
significance
better
understand
functional
view
this,
we
comprehensively
discussed
application
value
well
existing
problems
challenges.
Huntington’s
disease
(HD)
is
an
inherited
neurodegenerative
characterized
by
uncontrolled
movements,
emotional
disturbances,
and
progressive
cognitive
impairment.
It
estimated
to
affect
4.3
10.6
per
100,000
people
worldwide,
the
mean
prevalence
rate
among
all
published
studies,
reviews,
genetic
HD
registries
5.7
100,000.
A
key
feature
of
loss
striatal
neurons
cortical
atrophy.
Although
there
no
cure
at
present,
discovery
gene
causing
has
brought
us
into
a
new
DNA
era
therapeutic
advances
for
several
neurological
disorders.
PubMed
was
systematically
searched
using
three
search
strings:
‘“Huntington
disease”
+
“stem
cell”’,
‘”Huntington
Mesenchymal
stromal
cell’,
“induced
pluripotent
stem
cell”’.
For
each
string,
results
were
categorized
based
on
cell
type,
papers
that
included
clinical
analysis
as
well.
The
data
extracted
up
2024.
We
did
not
include
other
databases
in
our
have
comparable
systematic
review
literature
topic.
collected
analyzed
used
critical
interpretation
present
review.
Data
are
presented
chronologically
studies
published.
Therapeutic
strategies
cells
drawn
lot
interest
possible
therapies.
Recent
research
indicates
NSCs
been
most
often
utilized
type
treating
HD.
generated
from
variety
sources,
including
patients’
somatic
brain
itself.
There
strong
evidence
supporting
transplantation
or
their
derivatives
animal
models,
even
if
stem-cell-based
preclinical
trials
still
early
stages.
Current
treatment
only
aims
relieving
symptoms
rather
than
pathogenesis
disease.
models
shown
promise
improving
motor
functions,
therapy
faces
many
challenges
disadvantages
immunosuppression
immunorejection
well
ethical,
technical,
safety
concerns.
Further
required
definitive
conclusion.
Journal of Personalized Medicine,
Год журнала:
2022,
Номер
12(9), С. 1485 - 1485
Опубликована: Сен. 10, 2022
In
the
past,
several
animal
disease
models
were
developed
to
study
molecular
mechanism
of
neurological
diseases
and
discover
new
therapies,
but
lack
equivalent
has
minimized
success
rate.
A
number
critical
issues
remain
unresolved,
such
as
high
costs
for
developing
models,
ethical
issues,
resemblance
with
human
disease.
Due
poor
initial
screening
assessment
molecules,
more
than
90%
drugs
fail
during
final
step
clinical
trial.
To
overcome
these
limitations,
a
approach
been
based
on
induced
pluripotent
stem
cells
(iPSCs).
The
discovery
iPSCs
provided
roadmap
translation
research
regeneration
therapy.
this
article,
we
discuss
potential
role
patient-derived
in
their
contribution
scientific
future
medicine.
humaniPSCs
most
common
neurodegenerative
(e.g.,
Parkinson's
Alzheimer's
disease,
diabetic
neuropathy,
stroke,
spinal
cord
injury)
examined
ranked
per
published
literature
PUBMED.
We
have
observed
that
scored
highest,
followed
by
Furthermore,
also
explored
recent
advancements
field
personalized
medicine,
patient-on-a-chip
concept,
where
can
be
grown
3D
matrices
inside
microfluidic
devices
create
an
vitro
model
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1777 - 1777
Опубликована: Авг. 6, 2024
Huntington's
Disease
(HD)
is
a
neurodegenerative
disorder
caused
by
an
autosomal-dominant
mutation
in
the
huntingtin
gene,
which
manifests
with
triad
of
motor,
cognitive
and
psychiatric
declines.
Individuals
HD
often
present
disturbed
sleep/wake
cycles,
but
it
still
debated
whether
altered
circadian
rhythms
are
intrinsic
to
its
aetiopathology
or
consequence.
Conversely,
well
established
that
disturbances,
perhaps
acting
concert
other
pathophysiological
mechanisms,
worsen
impact
disease
on
motor
functions
burden
patients
their
caretakers.
Currently,
there
no
cure
stop
progression
HD,
however,
preclinical
research
providing
cementing
evidence
restoring
fluctuation
can
assist
delaying
onset
slowing
HD.
Here
we
highlight
application
circadian-based
interventions
models
provide
insights
into
potential
translation
clinical
practice.
Interventions
aimed
at
improving
cycles'
synchronization
have
shown
improve
deficits
models.
Therefore,
strong
support
for
suitability
ameliorate
symptoms
humans
emerges
from
literature,
albeit
gaps
our
knowledge
underlying
mechanisms
possible
risks
associated
implementation.
Cells,
Год журнала:
2025,
Номер
14(5), С. 347 - 347
Опубликована: Фев. 27, 2025
Neurodegenerative
diseases
encompass
a
number
of
very
heterogeneous
disorders,
primarily
characterized
by
neuronal
loss
and
concomitant
decline
in
neurological
function.
Examples
this
type
clinical
condition
are
Alzheimer's
Disease,
Parkinson's
Huntington's
Disease
Amyotrophic
Lateral
Sclerosis.
Age
has
been
identified
as
major
risk
the
etiology
these
which
explains
their
increased
incidence
developed
countries.
Unfortunately,
despite
continued
intensive
efforts,
no
cure
yet
found
for
any
diseases;
reliable
markers
that
allow
an
early
diagnosis
disease
identification
key
molecular
events
leading
to
onset
progression
lacking.
Altered
adult
neurogenesis
appears
precede
appearance
severe
symptoms.
Given
scarcity
human
samples
considerable
differences
with
model
species,
increasingly
complex
stem-cell-based
models
being
developed.
These
shedding
light
on
alterations
contribute
development,
facilitating
new
targets
providing
screening
platform
testing
candidate
drugs.
Moreover,
secretome
other
promising
features
cell
types
explored,
use
them
replacement
cells
high
plasticity
or
co-adjuvant
therapy
combinatorial
treatments.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 2, 2025
As
the
world's
population
ages,
neurodegenerative
diseases
are
becoming
more
widely
acknowledged
as
serious
global
health
and
socioeconomic
issues.
Although
many
resources
have
been
devoted
to
research
of
these
illnesses,
little
progress
has
made
in
creation
novel
diagnostic
therapeutic
approaches.
Extracellular
vesicles
(EVs)
released
by
all
cell
types
contain
proteins,
microRNAs,
mRNAs,
other
biologically
active
molecules.
EVs
play
an
important
role
intercellular
communication
well
regulation
neuroinflammation.
Determining
mechanisms
which
contribute
pathogenesis
will
aid
development
new
approaches
tools.
Mesenchymal
stem
cells
(MSCs)
shown
studies
control
immunological
responses,
promote
growth
brain
connections,
production
blood
vessels,
heal
damaged
tissues.
There
is
growing
evidence
that
MSCs'
ability
treat
patients
mostly
due
neurotrophic
compounds
they
secrete
through
EVs.
Since
their
tiny
size
allows
them
pass
biological
barriers
reach
injured
parts
central
nervous
system,
MSC-derived
extracellular
(MSC-EVs)
retain
qualities
parent
MSCs.
This
review
discusses
highlights
potential
MSC-EVs
treatment
diseases.
The
paper
also
examines
challenges
still
need
be
overcome
prospects
for
using
illnesses.
