Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
In
chronic
kidney
disease,
calcium
and
phosphate
imbalances
occur,
causing
numerous
dysfunctions
of
related
regulatory
mechanisms,
called
disease–mineral
bone
disorder
(CKD-MBD).
Its
consequences
include
impaired
health
heightened
risk
fractures,
extensive
soft
tissue
calcification,
most
significantly
affecting
arteries,
leading
to
the
deterioration
cardiovascular
health.
Over
past
decades,
many
pathophysiological
connections
have
been
found
markers
discovered
that
can
be
used
evaluate
status,
as
well
extent
vascular
calcifications.
These
a
multitude
older
newer
laboratory
parameters
imaging
methods.
The
use
effective
predictive
scoring
systems
improve
identification
patients
who
are
at
developing
complications.
Aside
from
discoveries
novel
markers,
opportunistic
some
commonly
utilised
diagnostic
methods
patient
has
already
undergone
for
other
indications
powerful
tool.
Diagnostics,
Год журнала:
2025,
Номер
15(4), С. 423 - 423
Опубликована: Фев. 10, 2025
Background/Objectives:
Post-translationally
modified
peptide
fragments
of
fetuin-A
(FetA)
were
identified
as
a
potential
biomarker
diabetic
kidney
disease
(DKD).
An
independent
association
between
urinary
FetA-derived
levels
(uPTM3-FetA)
and
DKD
progression
in
patients
with
type
2
diabetes
(T2D)
was
evidenced.
This
study
aimed
to
explore
uPTM3-FetA
excretion
its
associations
insulin
resistance,
inflammatory
metabolic
biomarkers
1
(T1D),
the
normal
albuminuria
estimated
glomerular
filtration
rate
(eGFR)
>
60
mL/min/1.73
m2.
Methods:
aliquots
24
h
urine
specimens,
routine
laboratory
renal,
tests,
adipokines
(leptin,
adiponectin,
resistin),
assessed
glucose
disposal
(eGDR),
measured
cohort
169
adult
T1D
patients.
To
evaluate
changes
early
renal
dysfunction,
divided
according
median
eGFR.
Above-
below-median-eGFR
groups
considered
having
declining
function,
respectively.
Results:
The
(IQR)
level
11.7
(8.43–16.65
µg/24
h),
no
significant
difference
males
females,
well
function
However,
sex-specific
analysis
revealed
significantly
higher
male
lower
eGFRs,
when
compared
those
whereas
such
observed
female
BMI,
hs-CRP,
resistin
HDL-cholesterol
predictors
excretion.
Conclusions:
Our
results
implicate
role
detection
an
dysfunction
T1DM
pinpoint
importance
approach
diagnostics
research.
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0312232 - e0312232
Опубликована: Фев. 13, 2025
In
this
systematic
review
we
have
sought
to
summarise
the
current
knowledge
concerning
biomarkers
that
can
distinguish
between
steroid-resistant
nephrotic
syndrome
and
steroid-sensitive
syndrome.
Additionally,
aim
select
best
evidence-base
should
be
prioritised
for
further
research.
Pub
med
web
of
science
databases
were
searched
using
“steroid
resistant
AND
biomarker”.
Papers
published
01/01/2012
10/05/2022
included.
did
not
compare
steroid
sensitive
syndrome,
report
sensitivity/specificity
or
area
under
curve
reviews/letters
excluded.
The
selected
papers
then
assessed
bias
QUADAS-2
tool.
source
biomarker,
cut
off,
sensitivity/specificity,
sample
size
all
extracted.
Quality
assessment
was
performed
BIOCROSS
17
studies
included,
comprising
15
case-control
2
cross-sectional
studies.
Given
rarity
difficulty
in
recruiting
large
cohorts,
accepted
despite
their
limitations.
We
present
a
range
candidate
along
with
scores
relating
quality
original
publications
risk
inform
future
investigations.
None
stated
whether
authors
blinded
patient’s
disease
when
assessing
index
test
cohort.
Highlighting
key
problem
field
needs
addressed.
These
must
now
tested
much
larger
sizes.
Using
new
biobanks
such
as
one
built
by
NURTuRE-INS
team
will
very
helpful
regard.
CHILD`S HEALTH,
Год журнала:
2025,
Номер
20(1), С. 41 - 47
Опубликована: Март 5, 2025
Background.
Considering
that
most
diagnostic
tests
for
diabetic
peripheral
polyneuropathy
(DPN)
are
not
suitable
use
in
childhood,
resulting
low
accuracy
of
this
complication,
there
is
a
need
to
identify
reliable
and
simple
markers
early
detection
monitoring
progression
children.
Purpose:
study
the
content
fetuin
A,
gamma-aminobutyric
acid
(GABA),
S100
protein
copeptin
blood
serum
children
with
type
1
diabetes
mellitus
determine
their
role
development
polyneuropathy.
Materials
methods.
We
examined
63
aged
10
17
years.
Group
included
26
patients
without
signs
neuropathy,
group
2
consisted
37
The
control
29
representative
terms
age
gender
carbohydrate
metabolism
disorders.
levels
acid,
protein,
were
determined
by
enzyme-linked
immunosorbent
assay
using
commercial
kits.
Results.
It
has
been
proven
who
did
have
DPN,
was
1.6-fold
increase
A
2.4-fold
GABA
compared
(p
<
0.05).
With
decrease
both
GABA.
significant
statistical
level
found
while
values
statistically
differ
from
>
An
severity
neurological
deficit
inversely
related
(r
=
–0.40;
p
0.05)
–0.45;
positively
correlated
0.66;
0.68;
Conclusions.
comprehensive
fetuin,
GABA,
can
act
as
an
additional
objective
marker
DPN
will
allow
objectification
improvement
diagnosis
complication.
Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
In
chronic
kidney
disease,
calcium
and
phosphate
imbalances
occur,
causing
numerous
dysfunctions
of
related
regulatory
mechanisms,
called
disease–mineral
bone
disorder
(CKD-MBD).
Its
consequences
include
impaired
health
heightened
risk
fractures,
extensive
soft
tissue
calcification,
most
significantly
affecting
arteries,
leading
to
the
deterioration
cardiovascular
health.
Over
past
decades,
many
pathophysiological
connections
have
been
found
markers
discovered
that
can
be
used
evaluate
status,
as
well
extent
vascular
calcifications.
These
a
multitude
older
newer
laboratory
parameters
imaging
methods.
The
use
effective
predictive
scoring
systems
improve
identification
patients
who
are
at
developing
complications.
Aside
from
discoveries
novel
markers,
opportunistic
some
commonly
utilised
diagnostic
methods
patient
has
already
undergone
for
other
indications
powerful
tool.
