The International Journal of Biochemistry & Cell Biology, Journal Year: 2024, Volume and Issue: 175, P. 106646 - 106646
Published: Aug. 23, 2024
Language: Английский
Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(3), P. 349 - 363
Published: Jan. 4, 2024
Language: Английский
Citations
14
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 10, 2024
Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to immunotherapy is suboptimal, primarily attributed low immunogenicity in certain types of malignant tumors. Immunogenic cell death (ICD) represents form regulated (RCD) capable enhancing tumor and activating tumor-specific innate adaptive responses immunocompetent hosts. Therefore, gaining deeper understanding ICD evolution crucial developing more therapeutic strategies. This review focuses exclusively on both historical recent discoveries related modes their mechanistic insights, particularly within context immunotherapy. Our findings are also highlighted, revealing mode induction facilitated by atypical interferon (IFN)-stimulated genes (ISGs), including polo-like kinase 2 ( PLK2 ), during hyperactive type I IFN signaling. The concludes discussing potential ICD, with special attention relevance preclinical settings field
Language: Английский
Citations
14
APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(9-10), P. 1330 - 1360
Published: July 16, 2024
Language: Английский
Citations
12
APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown
Published: June 17, 2024
Abstract Disulfidptosis is a novel form of cell death that distinguishable from established programmed pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process characterized by the rapid depletion nicotinamide adenine dinucleotide phosphate (NADPH) in cells high expression solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation actin cytoskeleton proteins, culminating network collapse disulfidptosis. review aimed to summarize underlying mechanisms, influencing factors, comparisons with traditional pathways, associations related diseases, application prospects, future research directions
Language: Английский
Citations
9
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 29, 2025
N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that commonly observed both prokaryotic and eukaryotic organisms. Their influence on the synthesis processing of messenger RNA, ribosomal transfer allows m7G modifications to affect diverse cellular, physiological, pathological processes. are pivotal human diseases, particularly cancer progression. On one hand, modification-associated modulate tumour progression malignant biological characteristics, including sustained proliferation signalling, resistance cell death, activation invasion metastasis, reprogramming energy metabolism, genome instability, immune evasion. This suggests they may be novel therapeutic targets for treatment. other aberrant expression molecules linked clinicopathological staging, lymph node unfavourable prognoses patients with cancer, indicating their potential as biomarkers. review consolidates discovery, identification, detection methodologies, functional roles modification, analysing mechanisms by which contribute development, exploring clinical applications diagnostics therapy, thereby providing innovative strategies identification targeted
Language: Английский
Citations
1
Molecular Carcinogenesis, Journal Year: 2024, Volume and Issue: 63(8), P. 1515 - 1527
Published: May 15, 2024
Abstract Paclitaxel serves as the cornerstone chemotherapy for ovarian cancer, yet its prolonged administration frequently culminates in drug resistance, presenting a substantial challenge. Here we reported that inducing alkaliptosis, rather than apoptosis or ferroptosis, effectively overcomes paclitaxel resistance. Mechanistically, ATPase H + transporting V0 subunit D1 (ATP6V0D1), key regulator of plays pivotal role by mediating downregulation ATP‐binding cassette subfamily B member 1 (ABCB1), multidrug resistance protein. Both ATP6V0D1 overexpression through gene transfection and pharmacological enhancement protein stability using JTC801 inhibit ABCB1 upregulation, resulting growth inhibition drug‐resistant cells. Additionally, increasing intracellular pH to alkaline (pH 8.5) via sodium hydroxide application suppresses expression, whereas reducing acidic conditions 6.5) with hydrochloric acid amplifies expression Collectively, these results indicate potentially effective therapeutic strategy targeting paclitaxel‐resistant cancer ATP6V0D1‐dependent alkaliptosis.
Language: Английский
Citations
8
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 10, 2024
Abstract Kidney Clear Cell Carcinoma (KIRC), the predominant form of kidney cancer, exhibits a diverse therapeutic response to Immune Checkpoint Inhibitors (ICIs), highlighting need for predictive models ICI efficacy. Our study has constructed prognostic model based on 13 types Programmed Death (PCD), which are intertwined with tumor progression and immune microenvironment. Validated by analyses comprehensive datasets, this identifies seven key PCD genes that delineate two subtypes distinct profiles sensitivities anti-PD-1 therapy. The high-PCD group demonstrates more immune-suppressive environment, while low-PCD shows better responses PD-1 treatment. In particular, TOP2A emerged as crucial, its inhibition markedly reducing KIRC cell growth mobility. These findings underscore relevance PCDs in predicting outcomes immunotherapy response, implications enhancing clinical decision-making.
Language: Английский
Citations
6
Carcinogenesis, Journal Year: 2024, Volume and Issue: unknown
Published: July 14, 2024
Alkaliptosis, a form of regulated cell death, is characterized by lysosomal dysfunction and intracellular pH alkalinization. The pharmacological induction alkaliptosis using the small molecule compound JTC801 has emerged as promising anticancer strategy in various types cancers, particularly pancreatic ductal adenocarcinoma (PDAC). In this study, we investigate novel mechanism which macropinocytosis, an endocytic process involving uptake extracellular material, promotes resistance to human PDAC cells. Through lipid metabolomics analysis functional studies, demonstrate that inhibition fatty acids, such oleic acid, not dependent on endogenous synthetic pathways but rather exogenous facilitated macropinocytosis. Consequently, targeting macropinocytosis through approaches (e.g., EIPA or EHoP-016) genetic interventions RAC1 knockdown) effectively enhances JTC801-induced These findings provide compelling evidence modulation can increase sensitivity cancer cells inducers.
Language: Английский
Citations
4
APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(11-12), P. 1860 - 1878
Published: July 28, 2024
Language: Английский
Citations
4
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca
Language: Английский
Citations
0