Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 18, 2024
Ewing
sarcoma
(ES),
the
second
main
pediatric
bone
sarcoma,
is
characterised
by
a
chromosomal
translocation
leading
to
formation
of
fusion
proteins
like
EWS::FLI1.
While
several
studies
have
shown
that
potassium
channels
drive
development
many
tumours,
limited
data
exist
on
ES.
This
work
therefore
aimed
study
transcriptional
regulation
KCNA2
and
define
involvement
Kv1.2
channel
encoded
in
key
function
ES
development,
cell
proliferation.
expression
patients
lines
was
measured
via
bioinformatic
analysis
(RNA-Seq).
The
presence
functional
using
patch-clamp
experiments.
Molecular
biology
approaches
were
used
after
EWS::FLI1
silencing
KCNA2.
Proliferation
count
assessment
performed
approaches.
(siRNA)
RNA-Seq
identify
signalling
pathways
involved
ability
Hippo
pathway
studied
measuring
Hippo/YAP
target
genes
expression,
while
YAP
protein
with
Western-Blot
immunofluorescence
research
identified
(encoding
for
channel)
as
highly
expressed
biopsies
lines.
results
indicated
correlation
between
patient
survival.
also
demonstrated
KCNA2/Kv1.2
direct
EWS::FLI1,
molecular
mechanisms
which
this
chimeric
regulates
gene
at
level.
Furthermore,
activity
regulate
proliferation
drives
pathway.
Using
specific
inhibitor
(κ-Conotoxin),
suggested
two
complementary
are
process,
both
dependently
independently
plasma
membrane.
first
describe
cancer
development.
unveiled
cascade.
Thus,
suggests
could
be
potential
therapeutic
The
prognosis
of
pediatric
acute
myeloid
leukemia
(AML)
remains
poor
compared
with
lymphoblastic
(ALL);
accurate
diagnosis
and
treatment
strategies
based
on
the
genomic
background
are
strongly
needed.
Recent
advances
in
sequencing
technologies
have
identified
novel
AML
subtypes,
including
BCL11B
structural
variants
UBTF
tandem
duplications
(UBTF-TD),
associated
prognosis.
In
contrast,
these
subtypes
do
not
fit
into
diagnostic
systems
for
5th
edition
WHO
classification
or
International
Consensus
Classifications
(ICC)
released
2022.
this
review,
we
describe
current
state
context
a
new
framework
findings
updated
profiling.
Molecular
categories
system
unique
transcriptional,
mutational,
clinical
characteristics,
which
can
be
leveraged
predicting
outcomes
developing
molecular-target
therapies
initiating
driver
alterations.
We
also
highlight
four
high-risk
AML,
namely
CBFA2T3::GLIS2,
BCL11B,
UBTF-TD,
ETS
family
fusions,
focusing
their
disease
mechanisms,
associations,
possible
therapeutic
to
overcome
dismal
Environmental Health,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 7, 2025
Abstract
Background
Incidence
of
childhood
Ewing
sarcoma,
a
rare
cancer
affecting
bones
and
soft
tissues,
is
increasing.
Environmental
exposures
during
the
perinatal
period,
like
air
pollution,
may
play
role.
We
examined
exposure
to
ambient
fine
particulate
matter
(PM
2.5
)
sarcoma
risk
in
case-control
linkage
study
nested
within
California
birth
cohort.
Methods
The
included
388
children
born
(1982–2015)
diagnosed
with
at
age
0–19
years
(1988–2015),
19,341
California-born
cancer-free
controls
frequency-matched
cases
on
year
(50:1
ratio).
Ambient
PM
concentrations
maternal
residence
were
averaged
separately
over
two
time
periods,
gestation
first
after
birth,
using
validated
ensemble-based
model
(categorized
as
quartiles).
estimated
odds
ratios
(ORs)
95%
confidence
intervals
(CIs)
for
association
between
risk,
adjusting
sex,
year,
race,
ethnicity,
weight,
education
stratifying
by
Hispanic
ethnicity
assess
potential
disparities
-related
risk.
Results
In
overall
population,
was
not
associated
when
considering
or
birth.
Among
children,
who
experienced
greater
pollution
compared
non-Hispanic
higher
levels
yielded
elevated
quartile
(Q2
OR
[95%
CI]
=
1.53
[0.94–2.51];
Q3
1.56
[0.95–2.56];
Q4
1.39
[0.79–2.47]).
also
relation
Conclusion
Our
results
provide
new
suggestive
evidence
that
contribute
although
these
findings
statistically
significant
specific
children.
These
require
replication
underscore
need
further
evaluate
role
-cancer
relationship
genetic
ancestry
measures
through
lens
environmental
justice.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4814 - 4814
Опубликована: Май 17, 2025
Bone
sarcomas,
including
Osteosarcoma,
Ewing’s
sarcoma,
and
Chondrosarcoma,
are
rare
yet
aggressive
tumors
with
high
metastatic
potential
poor
survival
outcomes.
Despite
advances
in
surgical
chemotherapeutic
techniques,
these
malignancies
remain
difficult
to
treat.
They
often
exhibit
resistance
conventional
therapies
associated
a
limited
prognosis
for
patients.
MicroRNAs
(miRNAs)
have
emerged
as
pivotal
regulators
of
cancer
biology,
orchestrating
crucial
processes
such
cell
proliferation,
apoptosis,
metastasis.
Their
double
life
oncogenes
or
tumor
suppressors
underscores
their
significance
the
pathogenesis
bone
sarcomas.
This
review
examines
multifaceted
roles
miRNAs
malignancies.
By
elucidating
complex
networks
affected
by
miRNA
dysregulation,
we
seek
identify
novel
avenues
miRNA-based
interventions.
It
is
intention
this
work
stimulate
future
research
clinical
strategies
that
exploit
transform
management
outcomes
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Май 23, 2025
Ewing
sarcoma
(ES),
particularly
Extra-skeletal
(EES),
is
a
rare,
aggressive
tumor
predominantly
affecting
adolescents
and
young
adults,
yet
it
can
occur
in
older
patients,
leading
to
misdiagnosis
delay
treatment.
The
standard
approach
includes
surgical
resection,
chemotherapy,
radiation
therapy
for
unresectable
disease.
This
case
report
presents
63-year-old
female
patient
with
history
of
triple-negative
breast
cancer,
who
was
discovered
have
soft
tissue
the
left
medial
thigh.
Initially
misdiagnosed
as
rhabdomyosarcoma,
diagnosis
EES
ultimately
confirmed
via
RNA
sequencing
revealing
EWSR1-FLI1
fusion
gene.
She
underwent
neoadjuvant
chemotherapy
followed
by
radical
resection
tumor.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 18, 2024
Sarcomas
comprise
between
10–15%
of
all
pediatric
malignancies.
Osteosarcoma
and
Ewing
sarcoma
are
the
two
most
common
bone
tumors
diagnosed
in
children
young
adults.
These
commonly
treated
with
surgery
and/or
radiation
therapy
combination
chemotherapy.
However,
there
is
a
strong
need
for
development
utilization
targeted
therapeutic
methods
to
improve
patient
outcomes.
Towards
accomplishing
this
goal,
pre-clinical
models
these
unique
malignancies
particular
importance
design
test
experimental
strategies
prior
being
introduced
patients
due
their
origination
site
propensity
metastasize.
Pre-clinical
offer
several
advantages
study
sarcomas
benefits
shortcomings
dependent
on
type
model.
This
review
addresses
types
available
solid
tumors,
special
attention
osteosarcoma
sarcoma.
