Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein/SOX10-Positive Neoplasm

Modern Pathology, Год журнала: 2024, Номер 37(8), С. 100537 - 100537

Опубликована: Июнь 12, 2024

Язык: Английский

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The RNA tether model for human chromosomal translocation fragile zones

Trends in Biochemical Sciences, Год журнала: 2024, Номер 49(5), С. 391 - 400

Опубликована: Март 14, 2024

Язык: Английский

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Novel classification system and high-risk categories of pediatric acute myeloid leukemia

Haematologica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

The prognosis of pediatric acute myeloid leukemia (AML) remains poor compared with lymphoblastic (ALL); accurate diagnosis and treatment strategies based on the genomic background are strongly needed. Recent advances in sequencing technologies have identified novel AML subtypes, including BCL11B structural variants UBTF tandem duplications (UBTF-TD), associated prognosis. In contrast, these subtypes do not fit into diagnostic systems for 5th edition WHO classification or International Consensus Classifications (ICC) released 2022. this review, we describe current state context a new framework findings updated profiling. Molecular categories system unique transcriptional, mutational, clinical characteristics, which can be leveraged predicting outcomes developing molecular-target therapies initiating driver alterations. We also highlight four high-risk AML, namely CBFA2T3::GLIS2, BCL11B, UBTF-TD, ETS family fusions, focusing their disease mechanisms, associations, possible therapeutic to overcome dismal

Язык: Английский

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Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)

Environmental Health, Год журнала: 2025, Номер 24(1)

Опубликована: Март 7, 2025

Abstract Background Incidence of childhood Ewing sarcoma, a rare cancer affecting bones and soft tissues, is increasing. Environmental exposures during the perinatal period, like air pollution, may play role. We examined exposure to ambient fine particulate matter (PM 2.5 ) sarcoma risk in case-control linkage study nested within California birth cohort. Methods The included 388 children born (1982–2015) diagnosed with at age 0–19 years (1988–2015), 19,341 California-born cancer-free controls frequency-matched cases on year (50:1 ratio). Ambient PM concentrations maternal residence were averaged separately over two time periods, gestation first after birth, using validated ensemble-based model (categorized as quartiles). estimated odds ratios (ORs) 95% confidence intervals (CIs) for association between risk, adjusting sex, year, race, ethnicity, weight, education stratifying by Hispanic ethnicity assess potential disparities -related risk. Results In overall population, was not associated when considering or birth. Among children, who experienced greater pollution compared non-Hispanic higher levels yielded elevated quartile (Q2 OR [95% CI] = 1.53 [0.94–2.51]; Q3 1.56 [0.95–2.56]; Q4 1.39 [0.79–2.47]). also relation Conclusion Our results provide new suggestive evidence that contribute although these findings statistically significant specific children. These require replication underscore need further evaluate role -cancer relationship genetic ancestry measures through lens environmental justice.

Язык: Английский

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The Double Life of microRNAs in Bone Sarcomas: Oncogenic Drivers and Tumor Suppressors

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4814 - 4814

Опубликована: Май 17, 2025

Bone sarcomas, including Osteosarcoma, Ewing’s sarcoma, and Chondrosarcoma, are rare yet aggressive tumors with high metastatic potential poor survival outcomes. Despite advances in surgical chemotherapeutic techniques, these malignancies remain difficult to treat. They often exhibit resistance conventional therapies associated a limited prognosis for patients. MicroRNAs (miRNAs) have emerged as pivotal regulators of cancer biology, orchestrating crucial processes such cell proliferation, apoptosis, metastasis. Their double life oncogenes or tumor suppressors underscores their significance the pathogenesis bone sarcomas. This review examines multifaceted roles miRNAs malignancies. By elucidating complex networks affected by miRNA dysregulation, we seek identify novel avenues miRNA-based interventions. It is intention this work stimulate future research clinical strategies that exploit transform management outcomes

Язык: Английский

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Extra-skeletal Ewing sarcoma in a 63-year-old female with a history of triple-negative breast cancer: a case report and literature review

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 23, 2025

Ewing sarcoma (ES), particularly Extra-skeletal (EES), is a rare, aggressive tumor predominantly affecting adolescents and young adults, yet it can occur in older patients, leading to misdiagnosis delay treatment. The standard approach includes surgical resection, chemotherapy, radiation therapy for unresectable disease. This case report presents 63-year-old female patient with history of triple-negative breast cancer, who was discovered have soft tissue the left medial thigh. Initially misdiagnosed as rhabdomyosarcoma, diagnosis EES ultimately confirmed via RNA sequencing revealing EWSR1-FLI1 fusion gene. She underwent neoadjuvant chemotherapy followed by radical resection tumor.

Язык: Английский

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Bone cancer: Biomarker landscape

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 75 - 109

Опубликована: Янв. 1, 2025

Язык: Английский

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Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Июль 18, 2024

Sarcomas comprise between 10–15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common bone tumors diagnosed in children young adults. These commonly treated with surgery and/or radiation therapy combination chemotherapy. However, there is a strong need for development utilization targeted therapeutic methods to improve patient outcomes. Towards accomplishing this goal, pre-clinical models these unique malignancies particular importance design test experimental strategies prior being introduced patients due their origination site propensity metastasize. Pre-clinical offer several advantages study sarcomas benefits shortcomings dependent on type model. This review addresses types available solid tumors, special attention osteosarcoma sarcoma.

Язык: Английский

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Signaling pathways and targeted therapies in Ewing sarcoma

Pharmacology & Therapeutics, Год журнала: 2024, Номер 266, С. 108765 - 108765

Опубликована: Ноя. 30, 2024

Язык: Английский

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Bioinformatics Analysis of the Biological Properties of Ewing Sarcoma

Journal of Biosciences and Medicines, Год журнала: 2024, Номер 12(06), С. 202 - 215

Опубликована: Янв. 1, 2024

Язык: Английский

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