Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management

Nutrients, Год журнала: 2024, Номер 16(17), С. 2996 - 2996

Опубликована: Сен. 5, 2024

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations efficacy tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, terpenoids, have demonstrated anti-inflammatory effects both preclinical clinical studies. By modulating responses promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies MS. This review provides insights into molecular cellular basis MS pathogenesis, emphasizing role inflammation disease progression. It critically evaluates emerging evidence supporting use plant-derived to attenuate symptomology. In addition, we provide comprehensive source information detailing known mechanisms action assessing context with focus on their neuroprotective properties.

Язык: Английский

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Systematic analysis of the global characteristics and reciprocal effects of S-nitrosylation and S-persulfidation in the human proteome

Free Radical Biology and Medicine, Год журнала: 2024, Номер 224, С. 335 - 345

Опубликована: Авг. 30, 2024

Gasotransmitter-mediated cysteine post-translational modifications, including S-nitrosylation (SNO) and S-persulfidation (SSH), play crucial roles interact in various biological processes. However, there has been a delay appreciating the interactional rules between SNO SSH. Here, all human S-nitrosylated S-persulfidated proteomic data were curated, comprehensive analyses from multiple perspectives, sequence, structure, function, exact protein impacts (e.g., up-/down-regulation), performed. Although these two modifications collectively regulated wide array of proteins to jointly maintain redox homeostasis, they also exhibited intriguing differences. First, tended be more accessible functionally clustered pathways associated with cell damage repair other such as phosphorylation ubiquitination. Second, SSH preferentially targeted cysteines disulfide bonds modulated tissue development immune-related pathways. Finally, regardless whether occupied same position given protein, their combined effect suppressive when acting synergistically; otherwise, likely inhibited while activated target protein. Indeed, side-by-side comparison shed light on globally reciprocal effects provided reference for further research gasotransmitter-mediated effects.

Язык: Английский

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Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells

Free Radical Research, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Дек. 8, 2024

Urban aerosol particulate matter (UPM) is widespread in the environment, and its concentration continues to increase. Several recent studies have reported that UPM results premature cellular senescence, but few investigated molecular basis of UPM-induced senescence retinal pigment epithelial (RPE) cells. In this study, we primarily evaluated protective function nuclear factor erythroid 2-related 2 (Nrf2) human RPE ARPE-19 The findings indicated exposure substantially induced cells, as observed by increased β-galactosidase activity, expression levels senescence-associated marker proteins, phenotypes. Such associated with mitochondrial oxidative stress-mediated phosphatidylinositol 3'-kinase/Akt/Nrf2 downregulation. Sulforaphane-mediated Nrf2 activation upregulation phosphorylated suppressed decrease target antioxidant gene, NAD(P)H quinone oxidoreductase 1, under UPM, which notably prevented cells from senescence. By contrast, knockdown exacerbated promoted stress. Collectively, our demonstrate regulatory role suggest a potential target.

Язык: Английский

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