Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107248 - 107248
Опубликована: Дек. 1, 2024
Язык: Английский
Cell Death and Disease, Год журнала: 2024, Номер 15(5)
Опубликована: Май 22, 2024
Abstract As a newly identified regulated cell death, ferroptosis is metabolically driven process that relies on iron and associated with polyunsaturated fatty acyl peroxidation, elevated levels of reactive oxygen species (ROS), mitochondrial damage. This distinct death dysregulated in various cancers; activating malignant cells increases cancer immunotherapy chemoradiotherapy responses across different malignancies. Over the last decade, accumulating research has provided evidence cross-talk between non-coding RNAs (ncRNAs) competing endogenous RNA (ceRNA) networks highlighted their significance developing progressing Aside from pharmaceutical agents to regulate ferroptosis, recent studies have shed light potential restoring ferroptosis-related ceRNA treatment. The present study provides comprehensive up-to-date review significance, pathways, role chemoradiotherapy, biogenesis, ferroptosis-regulating cancers. insights can offer authorship state-of-the-art findings future perspectives regarding implication treatment determining prognosis affected patients.
Язык: Английский
Процитировано
10
Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101534 - 101534
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Poultry Science, Год журнала: 2025, Номер 104(4), С. 104923 - 104923
Опубликована: Фев. 17, 2025
Avian leukosis virus subgroup J (ALV-J) is an immunosuppressive neoplastic virus, the growth retardation and performance of chickens after infection. Circular RNAs (circRNAs) play a crucial role in various types cancer. In previous study, we showed that circ-Vav3 was significantly elevated tumor livers avian leukosis-infected chickens. Autophagy essential cellular process, circRNAs have been confirmed to be key players autophagy regulation. this demonstrated overexpression inhibited autophagy. Specifically, functions as sponge for gga-miR-375, resulting increased expression CIP2A, which target gene gga-miR-375. turn, hinders fusion autophagosomes with lysosomes, leading incomplete autophagic flux, consequently, inhibition Further study gga-miR-375 inhibits CIP2A promotes by downregulating p-AKT. Additionally, treated cells rapamycin induce then cotransfected them The results cotransfection Moreover, exhibited further ALV-J infection, suggesting involved inhibiting caused infection through regulation gga-miR-375/CIP2A/AKT. conclusion, our gga-miR-375/CIP2A/AKT pathway mediated suppression ALV-J-induced
Язык: Английский
Процитировано
0
International Journal of Cancer Management, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 11, 2025
Background: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies globally. Non-coding RNAs (ncRNAs) are pivotal in regulating gene expression cancer progression, yet their precise functions within HCC pathways remain elucidated. Objectives: To investigate role ncRNAs key genes involved Hippo signaling to identify potential novel regulatory mechanisms progression. Methods: Gene data from GEO database (GSE14520) were analyzed for changes LEF1, MOB1A, PRKCB, SMARCA2 HCC. Physical interactions between selected (lnc-LRR1-1:1, lnc-LRR1-1:2, hsa_circ_0001380) target mRNAs predicted, using long non-coding RNA-target analysis resource (LncTAR) tool. miRNA was performed competing endogenous RNA (ceRNA) mechanisms. qPCR cell lines conducted experimental validation. Results: Significant upregulation LEF1 downregulation PRKCB observed samples. The strongest predicted identified lnc-LRR1-1:2 MOB1A isoforms. suggested that studied could act as ceRNAs. confirmed hsa_circ_0001380 slight lnc-LRR1-1:1,2 lines. Conclusions: This study unveils a complex network, where can modulate interactions, particularly hsa-miR-193b-3p suggest These findings provide new insights into pathogenesis avenues future research targeted therapies.
Язык: Английский
Процитировано
0
Non-coding RNA Research, Год журнала: 2025, Номер 12, С. 102 - 115
Опубликована: Март 4, 2025
As the earliest aging organ in reproductive system, ovary has both and endocrine functions, which are closely related to overall female health. The exact pathogenesis of ovarian (OA) remains incompletely understood, with granulosa cells (GCs) dysfunction playing a significant role this process. Recent advancements research biotechnology have highlighted importance non-coding RNAs (ncRNAs), including micro RNAs, long circular regulating biological functions GCs through gene expression modulation. This paper provides comprehensive overview ncRNAs various cellular such as apoptosis, autophagy, proliferation, steroid synthesis GCs, explores underlying regulatory mechanisms. Additionally, therapeutic potential ncRNAs, particularly those carried by exosomes derived from mesenchymal stem cells, delaying OA is discussed. Understanding mechanisms GC function current progress field crucial for identifying effective biomarkers targets, ultimately aiding early diagnosis, prognostic assessment, individualized treatment OA.
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Апрель 3, 2025
Cancer is a complex and highly lethal disease marked by unchecked cell proliferation, aggressive behavior, strong tendency to metastasize. Despite significant advancements in cancer diagnosis treatment, challenges such as early detection difficulties, drug resistance, adverse effects of radiotherapy or chemotherapy continue threaten patient survival. MicroRNAs (miRNAs) have emerged critical regulators biology, with miR-506 being extensively studied recognized for its tumor-suppressive across multiple types. This review examines the regulatory mechanisms common cancers, focusing on role competing endogenous RNA (ceRNA) network apoptosis, migration. We also discuss potential therapeutic target overcoming resistance treatment. Overall, these insights underscore promise developing novel therapies.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142865 - 142865
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Ovarian Research, Год журнала: 2025, Номер 18(1)
Опубликована: Май 16, 2025
Язык: Английский
Процитировано
0
IntechOpen eBooks, Год журнала: 2025, Номер unknown
Опубликована: Май 27, 2025
The expression of genes gets influenced by pseudogenes through their interactions with non-coding RNAs (ncRNAs) that include microRNAs (miRNAs) and long (lncRNAs) PIWI-interacting (piRNAs). This chapter seeks to describe pseudogene-ncRNA interactions, highlight new roles in cancer biology, discuss potential clinics. Pseudogenes act as competing endogenous (ceRNAs) bind miRNAs control the oncogenes tumor suppressors, thus affecting oncogenic tumor-suppressive pathways. Furthermore, pseudogene-derived lncRNAs piRNAs regulate transcription genome stability, which are crucial for progression. Recent studies have shown networks can be used biomarkers early detection, prognosis, therapeutic intervention. However, quite different from one type another. reviews current understanding a focus on significance improve diagnosis treatment.
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Апрель 5, 2024
LINK-A, also recognized as LINC01139, has emerged a key oncological lncRNA in cancer. LINK-A is upregulated solid and liquid tumor samples, including breast cancer, ovarian glioma, non-small-cell lung mantle cell lymphoma. Notably, involved regulating critical cancer-related pathways, such AKT HIF1α signaling, implicated range of oncogenic activities, proliferation, apoptosis, epithelial-mesenchymal transition (EMT), invasion migration, glycolysis reprogramming. LINK-A’s differential expression its correlation with clinical features enable it to be promising biomarker for cancer diagnosis, prognosis, the stratification progression. Additionally, contribution development resistance therapies, inhibitors immunotherapy, underscores potential therapeutic target. This review provides comprehensive overview available data on focusing molecular regulatory pathways significance. By exploring multifaceted nature aims offer valuable resource future research directions, potentially guiding novel strategies targeting this treatment.
Язык: Английский
Процитировано
2