ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Extracellular
vesicles
are
nanoscale
released
by
a
diversity
of
cells
that
mediate
intercellular
communication
transporting
an
array
biomolecules.
They
gaining
increasing
attention
in
cancer
research
due
to
their
ability
carry
specific
biomarkers.
This
characteristic
makes
them
potentially
useful
for
highly
sensitive,
noninvasive
diagnostic
procedures
and
more
precise
prognostic
assessments.
Consequently,
EVs
emerging
as
transformative
tool
treatment,
facilitating
early
detection
personalized
medicine.
Despite
significant
progress,
clinical
implementation
is
hindered
challenges
EV
isolation,
purification,
characterization.
However,
developing
advanced
biosensor
technologies
offers
promising
solutions
these
obstacles.
review
highlights
recent
progress
biosensors
analysis,
focusing
on
various
sensing
modalities
including
optical,
electrochemical,
microfluidic,
nanomechanical,
biological
sensors.
We
also
explore
techniques
characterization,
such
electron
microscopy,
atomic
force
nanoparticle
tracking
single-particle
analysis.
Furthermore,
the
critically
assesses
associated
with
put
forward
future
directions,
aiming
usher
cutting-edge
era
precision
medicine
through
advanced,
sensor-based,
diagnosis
detecting
EV-carried
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1822 - 1822
Опубликована: Авг. 11, 2024
The
increase
in
the
variety
of
nano-based
tools
offers
new
possibilities
to
approach
therapy
poorly
treatable
tumors,
which
includes
glioblastoma
multiforme
(GBM;
a
primary
brain
tumor).
available
nanocomplexes
exhibit
great
potential
as
vehicles
for
targeted
delivery
anti-GBM
compounds,
including
chemotherapeutics,
nucleic
acids,
and
inhibitors.
main
advantages
nanoparticles
(NPs)
include
improved
drug
stability,
increased
penetration
blood-brain
barrier,
better
precision
tumor
targeting.
Importantly,
alongside
their
drug-delivery
ability,
NPs
may
also
present
theranostic
properties,
applications
imaging
or
photothermal
malignant
cells.
can
be
classified
into
two
categories
according
core,
metal
non-metal
based.
Among
NPs,
most
studied
regard
GBM
treatment
are
exosomes,
liposomes,
cubosomes,
polymeric
micelles,
dendrimers,
nanogels,
carbon
nanotubes,
silica-
selenium-based
NPs.
They
characterized
by
satisfactory
stability
biocompatibility,
limited
toxicity,
high
accumulation
tissue.
Moreover,
they
easily
functionalized
cargo
Therefore,
discussed
here,
offer
promising
improving
outcomes
aggressive
tumors.
Vaccines,
Год журнала:
2024,
Номер
12(5), С. 519 - 519
Опубликована: Май 9, 2024
Cancer
remains
one
of
the
main
causes
death
in
world
due
to
its
increasing
incidence
and
treatment
difficulties.
Although
significant
progress
has
been
made
this
field,
innovative
approaches
are
needed
reduce
tumor
incidence,
progression,
spread.
In
particular,
development
cancer
vaccines
is
currently
ongoing
as
both
a
preventive
therapeutic
strategy.
This
concept
not
new,
but
few
have
approved
oncology.
Antigen-based
vaccination
emerges
promising
strategy,
leveraging
specific
antigens
activate
immune
system
response.
However,
challenges
persist
finding
suitable
delivery
systems
antigen
preparation
methods.
Exosomes
(EXs)
highly
heterogeneous
bilayer
vesicles
that
carry
several
molecule
types
extracellular
space.
The
peculiarity
they
may
be
released
from
different
cells
able
induce
direct
or
indirect
stimulation
system.
EX-based
cause
an
anti-tumor
attack
produce
memory
recognizing
inhibiting
disease
development.
review
delves
into
EX
composition,
biogenesis,
immune-modulating
properties,
exploring
their
role
tool
for
prevention
therapy
solid
tumors.
Finally,
we
describe
future
research
directions
optimize
vaccine
efficacy
realize
full
potential
immunotherapy.
Exosomes
are
nanoscale
vesicles
of
cellular
origin.
One
the
main
characteristics
exosomes
is
their
ability
to
carry
a
wide
range
biomolecules
from
parental
cells,
which
important
mediators
intercellular
communication
and
play
an
role
in
physiological
pathological
processes.
have
advantages
biocompatibility,
low
immunogenicity,
biodistribution.
As
researchers'
understanding
has
increased,
various
strategies
been
proposed
for
use
diagnosing
treating
diseases.
Here,
we
provide
overview
biogenesis
composition
exosomes,
describe
relationship
between
disease
progression,
focus
on
as
biomarkers
early
screening,
monitoring,
guiding
therapy
refractory
diseases
such
tumors
neurodegenerative
We
also
summarize
current
applications
especially
engineered
efficient
drug
delivery,
targeted
therapies,
gene
immune
vaccines.
Finally,
challenges
potential
research
directions
clinical
application
discussed.
In
conclusion,
emerging
molecule
that
can
be
used
diagnosis
treatment
diseases,
combined
with
multidisciplinary
innovative
solutions,
will
applications.
Cancer
remains
one
of
the
main
causes
death
in
world
due
to
its
increasing
incidence
and
treatment
difficulties.
Although
several
progresses
have
been
done
this
field,
innovative
approaches
are
needed
reduce
tumor
incidence,
progression
spreading.
In
particular,
development
cancer
vaccines
is
currently
ongoing
like
both
preventive
therapeutic
strategy.
This
concept
not
new,
but
few
approved
oncology.
Antigen-based
vaccination
emerges
as
a
promising
strategy,
leveraging
specific
antigens
activate
immune
system
response.
However,
challenges
persist
finding
suitable
delivery
systems
antigen
preparation
methods.
Exosomes
(EXs)
highly
heterogeneous
bilayered
vesicles
which
carry
molecule
types
extracellular
space.
The
peculiarity
that
they
may
be
released
from
different
cells
able
induce
direct
or
indirect
stimulation
system.
EX-based
cause
anti-tumor
attack
produce
memory
recognizing
inhibit
disease
appearance.
review
delves
into
EXs
composition,
biogenesis,
immune-modulating
properties
exploring
their
role
tool
for
prevention
therapy
solid
tumors.
Finally,
here
we
describe
future
research
directions
optimize
vaccine
efficacy
realize
full
potential
immunotherapy.
Expert Review of Molecular Diagnostics,
Год журнала:
2024,
Номер
unknown, С. 1 - 19
Опубликована: Окт. 3, 2024
Liquid
biopsy
is
an
innovative
advancement
in
oncology,
offering
a
noninvasive
method
for
early
cancer
detection
and
monitoring
by
analyzing
circulating
tumor
cells,
DNA,
RNA,
other
biomarkers
bodily
fluids.
This
technique
has
the
potential
to
revolutionize
precision
oncology
providing
real-time
analysis
of
dynamics,
enabling
detection,
treatment
responses,
tailoring
personalized
therapies
based
on
molecular
profiles
individual
patients.
Current Eye Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Фев. 4, 2025
A
growing
body
of
research
on
extracellular
vesicles
(EVs)
in
cancer
has
revealed
their
novel
and
crucial
activities
the
progression
tumors
while
also
paving
way
for
potential
therapeutic
interventions.
It
is
now
known
that
EVs
are
natural
delivery
vehicles
particular
payloads
source
cells,
enabling
them
to
influence
diverse
functions
cells
both
healthy
malignant
cells.
In
this
review,
we
comprehensively
summarize
mechanistic
insights
into
sEV
roles
RB,
most
frequent
intraocular
malignancy
affects
retina
young
children.
We
explore
sEVs
as
an
emerging
area
biomarkers
targeted
therapy.
Additionally,
address
challenges
limitations
translating
sEVs-based
technologies
clinical
practice.
