TIMP4 serves as a novel potential prognostic biomarker for oral squamous cell carcinoma
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 21, 2025
Язык: Английский
Differential expression and correlation analysis of global transcriptome for obstructive sleep apnea hypopnea syndrome
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 8, 2025
In
order
to
investigate
the
gene
expression
patterns
and
molecular
regulatory
mechanisms
of
obstructive
sleep
apnea
hypopnea
syndrome
(OSAHS),
global
transcriptome
profiles
OSAHS
patients
healthy
people
were
analyzed
using
sequencing
technology.
Differential
circular
RNA,
microRNA,
long
noncoding
messenger
RNA
was
investigated
between
two
groups.
To
further
explore
role
differentially
expressed
genes
in
OSAHS,
we
functionally
annotated
enrichment
analysis
GO
KEGG
pathways.
Finally,
ceRNA
network
constructed.
And
validate
mRNA
through
qRT-PCR
analysis.
The
results
showed
that
349
circRNAs,552
lncRNAs,205
miRNAs,
502
mRNAs
with
compared
population.
Terms
such
as
centrosome,
positive
regulation
execution
phase
apoptosis,
oxidoreductase
activity,
Th
17
cell
differentiation
immune
response,
neutrophil
mediated
cytotoxicity
enriched
list,
suggesting
a
potential
correlation
OSAHS.
Pathway
Ferroptosis,
Herpes
simplex
virus
1
infection,
Pathways
cancer,
Hematopoietic
lineage
other
pathways
play
an
important
By
constructing
ternary
network,
circRNAs
four
lncRNAs
screened
ceRNAs
compete
miRNAs
co-expression
associated
by
regulating
function
network.
quaternary
miR-8485
miR-6089
found
be
top
ranked
most
closely
Both
similar
trends.
This
provides
more
theoretical
basis
for
exploring
complex
development
Язык: Английский
Absence of CDK12 in oocyte leads to female infertility
Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 27, 2025
Язык: Английский
Multifaceted role of haptoglobin: Implications for disease development
World Journal of Hematology,
Год журнала:
2024,
Номер
11(3)
Опубликована: Сен. 19, 2024
Haptoglobin,
a
protein
primarily
recognized
for
its
role
in
sequestering
free
hemoglobin,
has
been
identified
as
molecule
with
diverse
and
underexplored
functions
the
pathophysiology
of
various
diseases.
This
editorial
explores
multifaceted
roles
haptoglobin,
highlighting
involvement
inflammatory
responses
immune
regulation
potential
implications
chronic
diseases
such
diabetes,
cardiovascular
disorders,
cancer.
Through
synthesis
recent
research
findings,
this
reveals
importance
haptoglobin
disease
mechanisms
underscores
need
further
investigation
to
fully
elucidate
therapeutic
potential.
A
comprehensive
understanding
haptoglobin’s
novel
may
catalyze
development
innovative
diagnostic
modalities
clinical
practice.
Язык: Английский
Absence of CDK12 in oocyte leads to female infertility
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
Transcriptional
activity
and
gene
expression
are
essential
for
the
development
of
a
mature,
meiotically
competent
oocyte.
We
have
found
that
absence
cyclin-dependent
kinase
12
(CDK12)
in
oocytes
leads
to
complete
female
sterility,
as
there
no
fully
developed
able
accomplish
meiosis
I
ovaries.
Mechanistically,
CDK12
growing
controls
POLII
maintenance
physiological
maternal
transcriptome,
which
negatively
affects
protein
synthesis
promotes
further
oocyte
growth.
In
addition,
disruption
disrupts
folliculogenesis,
resulting
premature
failure
phenotype
without
terminal
folliculogenesis
ovulation.
summary,
we
characterized
single
master
regulator
transcriptional
program
is
growth
fertility.
Graphical
Язык: Английский