Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Language: Английский

Autophagy-dependent versus autophagy-independent ferroptosis DOI Creative Commons

Ye Zhu,

Motoki Fujimaki,

David C. Rubinsztein

et al.

Trends in Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which contexts determine roles of autophagy in ferroptosis. This opinion article addresses this by summarizing and/or diseases a driver or suppressor The execution ferroptosis depends levels (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that context these three factors their upstream pathways are differentially regulated dictates whether positively negatively regulates

Language: Английский

Citations

1
WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma DOI

Tianfeng Yang,

Suyu Zhang, Kun Nie

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116790 - 116790

Published: Jan. 31, 2025

Language: Английский

Citations

0
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation DOI
Yan Niu, Chunyu Liu, Lizhou Jia

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 8, 2025

Language: Английский

Citations

0
WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer DOI Creative Commons
Yang Wang,

Dachuan Qi,

Gaoxiang Ge

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 12, 2025

Abstract Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein 1 (WBP1) affects mitochondrial function, growth, and chemoresistance CRC cells. By employing both genetic pharmacological methods, found WBP1 is essential maintaining respiration depletion impaired leading reduced proliferation increased ferroptosis. Exogenous mitochondria from wild-type cells restored proliferation, suppressed ferroptosis WBP1-deficient cells, indicating function acts downstream WBP1. Importantly, demonstrated targeting or its mediated sensitized chemoresistant 5-fluorouracil oxaliplatin by inducing Furthermore, analyzed transcriptome data patients, which indicated expression correlated with poor patients receiving chemotherapy, thus highlighting the clinical significance our observations. Collectively, results pinpoint as modulator imply may represent viable approach tackling These insights offer deeper understanding molecular pathways underlying guide development new treatment options.

Language: Английский

Citations

0
FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114524 - 114524

Published: March 1, 2025

Language: Английский

Citations

0
Targeting mitochondria-regulated ferroptosis: A new frontier in Parkinson’s Disease therapy DOI Creative Commons
Wenjun Wang,

Elizabeth Rosalind Thomas,

Rui Xiao

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110439 - 110439

Published: March 1, 2025

Language: Английский

Citations

0
Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species DOI
Saurabh Kumar,

Deepak Singh Kapkoti,

Pooja Rani Mina

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(6)

Published: April 22, 2025

Language: Английский

Citations

0
Exploring the Therapeutic Targets and Mechanisms of Lanxangia Tsaoko Methanol Extract in Ulcerative Colitis Using Uhplc-Qtof-Ms/Ms and Multi-Omics Analysis DOI

Jun Ge,

Xingke Zhu, Cheng Li

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Language: Английский

Citations

0