A Nomogram Based on Ocular Hemodynamics for Predicting Ischemic Stroke
American Journal of Ophthalmology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Ischemic
stroke
is
a
cerebrovascular
disease
with
high
mortality
and
disability.
Due
to
similar
physiological
characteristics,
ocular
vascular
characteristics
are
important
indicators
for
monitoring
diseases.
This
study
aimed
develop
nomogram
prediction
model
ischemic
based
on
hemodynamic
characteristics.
Retrospective
clinical
cohort
study.
A
total
of
337
patients
were
included
in
this
randomly
divided
into
253
training
102
validation
cohorts.
The
general
data
collected,
the
parameters
ophthalmic
artery,
central
retinal
artery
posterior
ciliary
detected
by
ultrasound.
diameter
was
extracted
from
color
fundus
image,
relevant
laboratory
indexes
collected.
Logistic
regression
analysis
used
determine
risk
factors
stroke.
constructed
identified
factors,
accuracy
applicability
analyzed
using
receiver
operating
curve
(ROC),
Hosmer-Lemeshow
test,
decision
(DCA).
Independent
including
hypertension
(OR
2.17,
95%
confidence
interval
[CI]
1.16
4.08;
P
=
0.016),
hyperlipidemia
2.21,
CI
1.18
4.14;
0.013),
resistance
index
5.98,
3.27
10.93;
<
0.001)
multivariate
analysis.
area
under
ROC
0.790
(95%
0.733
0.847)
that
0.773
0.679
0.866),
revealing
consistent
ability
predict
mean
absolute
error
train
cohorts
0.020
0.013,
respectively.
In
addition,
DCA
showed
good
benefit.
combining
traditional
has
preferable
predictive
performance
suggests
combined
hemodynamics
can
effectively
promote
early
diagnosis
intervention
Язык: Английский
Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure
Circulation Research,
Год журнала:
2025,
Номер
136(11), С. 1306 - 1334
Опубликована: Май 22, 2025
Chronic
kidney
disease
(CKD)
represents
a
global
health
issue
with
high
socioeconomic
impact.
Beyond
progressive
decline
of
function,
patients
CKD
are
at
increased
risk
cardiovascular
diseases,
including
heart
failure
(HF)
and
sudden
cardiac
death.
HF
in
can
manifest
both
as
reduced
ejection
fraction
preserved
fraction,
the
latter
further
increasing
relative
importance
more
advanced
stages
CKD.
Typical
remodeling
characteristics
uremic
cardiomyopathy
include
left
ventricular
hypertrophy,
myocardial
fibrosis,
electrical
dysregulation,
capillary
rarefaction,
microvascular
dysfunction,
which
triggered
by
preload,
afterload,
preload
afterload-independent
factors.
The
pathophysiological
mechanisms
underlying
multifactorial
neurohormonal
activation
(with
renin-angiotensin-aldosterone
system,
sympathetic
nervous
mineralocorticoid
receptor
signaling),
steroid
activation,
mitochondrial
inflammation,
innate
immune
oxidative
stress.
Furthermore,
disturbances
metabolism
calcium
homeostasis,
macrovascular
cellular
profibrotic
responses,
accumulation
retention
solutes,
mineral
bone
disorders
also
contribute
to
Here,
we
review
current
knowledge
CKD,
clinical
revealed
animal
studies.
We
elaborate
on
detrimental
impact
comorbidities
using
hypertension
an
example
discuss
hypertensive
genetic
predisposition.
Overall,
this
aims
increase
understanding
support
future
research
translational
approaches
for
improved
diagnosis
therapy
vulnerable
patient
population.
Язык: Английский
Crosstalk between lipid metabolism and macrophages in atherosclerosis: therapeutic potential of natural products
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 3, 2025
Atherosclerosis
is
a
highly
prevalent
cardiovascular
condition
that
affects
individuals
worldwide.
Despite
ongoing
research
into
its
treatment
and
prevention,
atherosclerotic
disease
continues
to
exhibit
high
morbidity
mortality
rates.
The
accumulation
of
low-density
lipoprotein
cholesterol
considered
major
contributor
the
development
atherosclerosis,
with
abnormalities
in
lipid
metabolism
playing
significant
role
pathogenesis.
Lipid
macrophage
function
are
intricately
interconnected,
being
influenced
by
inflammatory
responses,
while
activity
regulated
alterations
metabolism.
interaction
between
these
two
processes
plays
critical
progression
atherosclerosis.
Natural
products
have
shown
considerable
promise
treating
variety
diseases,
including
Moreover,
modulation
crosstalk
represents
key
mechanism
through
which
natural
may
exert
their
effects.
This
aims
provide
new
insights
current
state
on
regulating
this
pathway
interplay
macrophages
context
offering
potential
directions
for
future.
Язык: Английский
Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches
Cardiovascular Endocrinology & Metabolism,
Год журнала:
2025,
Номер
14(2)
Опубликована: Апрель 16, 2025
Insulin
resistance
(IR)
and
microvascular
ischemia
together
result
in
cardiovascular
dysfunction
by
impairing
the
heart’s
energy
balance.
IR
cardiomyocytes
disrupts
glucose
metabolism,
leading
to
deficits
that
can
drive
cardiac
hypertrophy
heart
failure.
Microvascular
exacerbates
these
effects
limiting
oxygen
nutrient
delivery,
intensifying
oxidative
stress,
mitochondrial
dysfunction,
cell
death.
also
reduces
effectiveness
of
vasodilators
like
nitroglycerin
sodium
nitroprusside,
exacerbating
endothelial
thus
delivery
during
ischemia.
This
combination
heightens
risk
left
ventricular
Understanding
interactions
is
critical
for
developing
targeted
therapies
improve
outcomes
patients
with
ischemic
disease.
study
examines
relationship
between
IR,
ischemia,
myocardial
a
focus
on
clinical
management
therapeutic
strategies.
Язык: Английский
Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Monocyte/lymphocyte bioenergetic signatures post-TB treatment
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
The
impact
of
human
pulmonary
tuberculosis
(TB)
on
the
bioenergetic
metabolism
circulating
immune
cells
remains
elusive,
as
does
resolution
these
effects
with
TB
treatment.
In
this
study,
rates
oxidative
phosphorylation
(OXPHOS)
and
glycolysis
in
lymphocytes
monocytes
patients
drug-susceptible
at
diagnosis,
2
months,
6
months
during
treatment,
12
after
diagnosis
were
investigated
using
extracellular
flux
analysis.
At
parameters
both
blood
severely
impaired
comparison
to
non-TB
non-HIV-infected
controls.
However,
most
not
affected
by
HIV
status
or
glycemic
index.
Treatment
restored
%
spare
respiratory
capacity
(%SRC)
that
observed
non-HIV
infected
controls
months.
also
improved
maximal
respiration
%SRC
patients.
Notably,
differential
correlation
clinical
from
baseline
month
was
consistent
metabolic
health
inflammation
following
successful
Network
analysis
serum
cytokine
levels
indicated
a
highly
coordinated
response
6.
These
findings
underscore
importance
combating
TB,
supporting
need
for
further
investigation
immunometabolism
associated
infection
novel
therapeutic
approaches
aimed
bolstering
cellular
energetics
enhance
responses
expedite
recovery
Язык: Английский
Multi-Omics Research on Angina Pectoris: A Novel Perspective
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Angina
pectoris
(AP),
a
clinical
syndrome
characterized
by
paroxysmal
chest
pain,
is
caused
insufficient
blood
supply
to
the
coronary
arteries
and
sudden
temporary
myocardial
ischemia
hypoxia.
Long-term
AP
typically
induces
other
cardiovascular
events,
including
infarction
heart
failure,
posing
serious
threat
patient
safety.
However,
AP's
complex
pathological
mechanisms
developmental
processes
introduce
significant
challenges
in
rapid
diagnosis
accurate
treatment
of
its
different
subtypes,
stable
angina
(SAP),
unstable
(UAP),
variant
(VAP).
Omics
research
has
contributed
significantly
revealing
various
diseases
with
development
high-throughput
sequencing
approaches.
The
application
multi-omics
approaches
effectively
interprets
systematic
information
on
from
perspective
genes,
RNAs,
proteins,
metabolites.
Integrating
introduces
novel
avenues
for
identifying
biomarkers
distinguish
subtypes.
This
study
reviewed
articles
related
elaborate
progress
(including
genomics,
transcriptomics,
proteomics,
metabolomics),
summarized
their
applications
screening
employed
discriminate
multiple
delineated
integration
methods
Finally,
we
discussed
advantages
disadvantages
applying
single-omics
approach
distinguishing
diverse
Our
review
demonstrated
that
technologies
preferable
quick
precise
three
types,
namely
SAP,
UAP,
VAP.
Язык: Английский