Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

и другие.

Journal of Immunology Research, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Язык: Английский

Revealing the role of regulatory b cells in cancer: development, function and treatment significance DOI Creative Commons

Ruyu Ye,

Sijia Li, Yuxiao Li

и другие.

Cancer Immunology Immunotherapy, Год журнала: 2025, Номер 74(4)

Опубликована: Фев. 25, 2025

B cells are essential components of the immune response, primarily recognized for their ability to produce antibodies. However, emerging research reveals important roles in regulating responses and influencing tumor development, independent The connection between progression alterations microenvironment is well-established, as infiltrating can enhance survival by modifying surroundings. Despite this, majority studies have focused on T macrophages, creating a gap our understanding cells. Regulatory (Bregs) represent crucial subpopulation that plays significant role maintaining balance. They may substantial impact immunity negatively tumor-infiltrating This paper reviews existing literature Bregs, examining phenotypes, functions, mechanisms through which they exert regulatory effects. Furthermore, we highlight potential interventional prognostic significance cancer therapy. By addressing current gaps knowledge regarding Bregs within tumors, hope inspire further could lead innovative treatments improved outcomes patients.

Язык: Английский

Процитировано

0
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

и другие.

Journal of Immunology Research, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Язык: Английский

Процитировано

0