Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Revealing the role of regulatory b cells in cancer: development, function and treatment significance DOI Creative Commons

Ruyu Ye,

Sijia Li, Yuxiao Li

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

B cells are essential components of the immune response, primarily recognized for their ability to produce antibodies. However, emerging research reveals important roles in regulating responses and influencing tumor development, independent The connection between progression alterations microenvironment is well-established, as infiltrating can enhance survival by modifying surroundings. Despite this, majority studies have focused on T macrophages, creating a gap our understanding cells. Regulatory (Bregs) represent crucial subpopulation that plays significant role maintaining balance. They may substantial impact immunity negatively tumor-infiltrating This paper reviews existing literature Bregs, examining phenotypes, functions, mechanisms through which they exert regulatory effects. Furthermore, we highlight potential interventional prognostic significance cancer therapy. By addressing current gaps knowledge regarding Bregs within tumors, hope inspire further could lead innovative treatments improved outcomes patients.

Language: Английский

Citations

0
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Citations

0