Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 393 - 410
Опубликована: Дек. 25, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1232 - 1232
Опубликована: Сен. 21, 2024
Silver nanoparticles (AgNPs) are leading the way in nanotechnological innovation, combining captivating properties of silver with accuracy nanoscale engineering, thus revolutionizing material science. Three main techniques arise within alchemical domains AgNP genesis: chemical, physical, and biological synthesis. Each possesses its distinct form magic for controlling size, shape, scalability—key factors necessary achieving expertise practical application nanoparticles. The story unravels, describing careful coordination chemical reduction, environmentally sensitive charm green synthesis utilizing plant extracts, precise physical techniques. AgNPs highly praised field healthcare their powerful antibacterial characteristics. These little warriors display a wide-ranging attack against bacteria, fungi, parasites, viruses. Their critical significance combating hospital-acquired surgical site infections is praised, serving as beacon hope fight challenging problem antibiotic resistance. In addition to ability kill also known promote tissue regeneration facilitate wound healing. cancer has observed adaptability AgNPs. review documents role innovative carriers drugs, specifically designed target cells accuracy, minimizing harm healthy tissues. Additionally, it explores potential therapy or anticancer agents capable disrupting growth tumors. food business, utilized enhance durability packing materials coatings by infusing them bactericidal properties. This results improved safety measures significant increase duration that products can be stored, thereby tackling crucial issue preservation. academic analysis recognizes many difficulties come creation incorporation statement pertains evaluation environmental effort synthetic processes. predicts future pursuits, envisioning progress will usefulness importance from being new becoming essential realms science industry. Besides, not only subject scholarly interest but component continuous tackle some most urgent health conservation concerns contemporary society. aims explore complex process highlight numerous uses, special focus on growing business sectors. invites scientific community extensive possibilities order fully understand utilize potential.
Язык: Английский
Процитировано
9
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 28, 2025
Gut microbiota, which act as a determinant of pharmacokinetics, have long been overlooked. In recent years, growing body evidence indicates that the gut microbiota influence drug metabolism and efficacy. Conversely, drugs also exert substantial on function composition microbiota. Pharmacomicrobiomics, an emerging field focusing interplay provides potential foundation for making certain advances in personalized medicine. Understanding communication between antiparkinsonian is critical precise treatment Parkinson's disease. Here, we provide historical overview drugs. Moreover, discuss mechanistic insights into complex associations metabolism. addition, draw attention to microbiota-based biomarkers predicting efficacy examine current state-of-the-art knowledge strategies optimize therapy
Язык: Английский
Процитировано
1
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101041 - 101041
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 658 - 658
Опубликована: Янв. 4, 2024
High-throughput genetic screening is useful for discovering critical genes or gene sequences that trigger specific cell functions and/or phenotypes. Loss-of-function mainly achieved through RNA interference (RNAi), CRISPR knock-out (CRISPRko), and (CRISPRi) technologies. Gain-of-function depends on the overexpression of a cDNA library activation (CRISPRa). Base editing can perform both gain- loss-of-function screening. This review discusses techniques based Cas9 nuclease, including Cas9-mediated genome dCas9-based interference. We compare these methods with previous RNAi propose future prospects applications
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13302 - 13302
Опубликована: Дек. 11, 2024
This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.
Язык: Английский
Процитировано
4
Parasite Immunology, Год журнала: 2025, Номер 47(1)
Опубликована: Янв. 1, 2025
ABSTRACT Tritrichomonas foetus is a protozoan parasite that causes bovine trichomonosis (also referred to as trichomoniasis) resulting in substantial economic loss extensive grazing systems. The colonises the reproductive tracts of both male and female cattle, being asymptomatic males but causing early failure infected females. This systematic review aimed examine research manuscripts describing development T. vaccines, strategies employed, immune response associated with infection. A was conducted using indexed sources on Scopus, PubMed, Web Science, Embase search for published vaccine studies English utilising either experimental or commercial vaccines trichomonosis. Search terms (cattle, bull, heifer, vaccine, response, ) were entered into no limit set year publication. Among 374 imported screening, 96 duplicates, 255 excluded irrelevancy these did not meet inclusion criteria (report original data, tests used incorporated antigens from ). further five after full‐text publication described different target pathogen full text English. Eighteen met subjected data extraction Covidence platform. Studies included reported three strategies, including subunit, cell fraction, whole‐cell killed vaccines. considers design, rationale, results each 18 provide comprehensive overview current knowledge inform future agendas. While are most prevalent, they have shown superior efficacy compared subunit studied date. One study purified fractions membranes demonstrated higher calving rates vaccine. All methods require culture growth which can be challenging production recombinant proteins. At this stage, been reported. Advances understanding parasite's genome, pathogenesis, host–parasite interactions, host responses will opportunities novel
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0
Polymer-Plastics Technology and Materials, Год журнала: 2025, Номер unknown, С. 1 - 27
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
AAPS PharmSciTech, Год журнала: 2024, Номер 25(5)
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
3
Journal of Oral Biosciences, Год журнала: 2024, Номер 66(3), С. 511 - 518
Опубликована: Июнь 21, 2024
Язык: Английский
Процитировано
3