Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model

Inflammatory Bowel Diseases, Год журнала: 2024, Номер 30(5), С. 844 - 853

Опубликована: Янв. 27, 2024

Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model colitis is arguably most widely used animal studying potential treatments ulcerative (UC), which a primary form IBD. This offers several advantages as research tool: it highly reproducible, relatively easy to generate maintain, mimics many critical features human Recently, has also been study role gut microbiota development progression investigate effects other factors, such diet genetics, on severity. However, although DSS-induced popular flexible preclinical research, not an exact replica colitis, some results obtained from this cannot be directly applied humans. review aims comprehensively discuss different that may issues should considered when using translational purposes.

Язык: Английский

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Fecal microbiota transplantation: current challenges and future landscapes

Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(2)

Опубликована: Май 8, 2024

SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest developing innovative therapeutic strategies for restoring microbiota. One such approach, fecal microbiota transplantation (FMT), is main "whole microbiome replacement" strategy and integrated into clinical practice guidelines treating recurrent

Язык: Английский

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Rational Design of Orally Administered Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Advanced Materials, Год журнала: 2023, Номер 35(44)

Опубликована: Авг. 23, 2023

Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy established address multifaceted demands, including intrinsic stability, radioactivity, solubility, gut microbiome toxicity, biomimetic elements, intermediate frontier molecular orbitals, reaction energy barriers, negative charges, acid tolerance. Ni3 S4 selected as best matching material from 146 323 candidates, which exhibits superoxide dismutase-catalase bienzyme-like activity 3.13- 1.80-fold more active than natural enzymes. As demonstrated mouse model, stable gastrointestinal tract without toxicity specifically targets diseased colon alleviate oxidative stress. RNA 16S rRNA sequencing analyses show that effectively inhibits cellular pathways pro-inflammatory factors restores microbiota. This study not develops highly efficient administered cascade nanozyme offers next-generation paradigm rational design nanomedicine through data-driven approaches.

Язык: Английский

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Heavy arch: from inflammatory bowel diseases to metabolic disorders

Gut, Год журнала: 2024, Номер 73(8), С. 1376 - 1387

Опубликована: Май 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Язык: Английский

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Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals

Nature Microbiology, Год журнала: 2025, Номер 10(1), С. 41 - 52

Опубликована: Янв. 6, 2025

Abstract As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences diet pattern (omnivore, vegetarian and vegan) are reflected microbiomes. Microbial distinguished these common patterns well (mean AUC = 0.85). Red meat was a strong driver of omnivore microbiomes, with corresponding signature microbes (for example, Ruminococcus torques , Bilophila wadsworthia Alistipes putredinis ) negatively correlated host cardiometabolic health. Conversely, vegan were favourable markers enriched omnivores consuming more foods. Diet-specific partially overlapped food especially dairy microbes, for Streptococcus thermophilus typical soil vegans. The signatures western can support future nutritional interventions epidemiology.

Язык: Английский

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Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1016 - 1016

Опубликована: Март 27, 2023

Inflammatory bowel diseases represent a complex array of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory disease, promising method treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increasing effectiveness and safety in recent years for recurrent CDI; moreover, it showed real clinical benefits treating SARS-CoV-2 CDI co-infection. Crohn’s disease ulcerative colitis are characterized immune dysregulation, resulting digestive damage caused responses. Most current therapeutic strategies associated with high costs many adverse effects directly targeting the response, so modifying microbial environment offers an alternative approach could indirectly influence host’s system safe way. Studies outline endoscopic improvements UC CD patients versus control groups. This review outlines multiple case IBD improving unbalanced gut, therefore symptomatology. We aim emphasize importance order prevent flares or complications highlight further validation needed establishing protocol IBD.

Язык: Английский

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Immune-mediated inflammatory diseases: Common and different pathogenic and clinical features

Autoimmunity Reviews, Год журнала: 2023, Номер 22(10), С. 103410 - 103410

Опубликована: Авг. 18, 2023

The term "immune-mediated inflammatory diseases (IMIDs)" refers to several pathologies of multifactorial etiology and involving either simultaneously or sequentially more organs. IMIDs share some common pathogenic mechanisms, which account for similarities in the clinical course impact that these may have on other organs systems body. However, there are differences IMID-associated pathological process, including synthesis function multiple cytokines, supposed perpetuate tissue-damaging inflammation. This justifies different indications responsiveness corticosteroids, immunosuppressors, small molecules, biologics. Many individuals with are, however, intolerant, unresponsive current drugs, thus suggesting necessity novel therapeutic approaches, such as combination compounds inhibit immuno-inflammatory networks selectively suppress signals activate counter-regulatory pathways. In this article, we highlight most relevant features discuss how clinicians can combat detrimental immune response disorders.

Язык: Английский

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Colonization with two different Blastocystis subtypes in DSS-induced colitis mice is associated with strikingly different microbiome and pathological features

Theranostics, Год журнала: 2023, Номер 13(3), С. 1165 - 1179

Опубликована: Янв. 1, 2023

Rationale:The gut microbiota plays a significant role in the pathogenesis of inflammatory bowel disease (IBD).However, Blastocystis infection and Blastocystis-altered development diseases their underlying mechanisms are not well understood.Methods: We investigated effect ST4 ST7 on intestinal microbiota, metabolism, host immune responses, then explored microbiome dextran sulfate sodium (DSS)-induced colitis mice.Results: This study showed that prior colonization with conferred protection from DSS-induced through elevating abundance beneficial bacteria, short-chain fatty acid (SCFA) production proportion Foxp3 + IL-10-producing CD4 T cells.Conversely, exacerbated severity by increasing pathogenic bacteria inducing pro-inflammatory IL-17A TNF-α-producing cells.Furthermore, transplantation ST4-and ST7-altered resulted similar phenotypes.Conclusions: Our data exert strikingly differential effects these could influence susceptibility to colitis.ST4 prevented mice may be considered as novel therapeutic strategy against immunological future, while is potential risk factor for experimentally induced warrants attention.

Язык: Английский

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MAIT cells and the microbiome

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 23, 2023

Mucosal associated invariant T (MAIT) cells are innate-like lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis presented the MHC-Ib molecule MR1. At barrier sites MAIT occupy prime position for interaction with commensal microorganisms, comprising microbiota. The microbiota is rich source antigens required in early life to promote intra-thymic development sustain life-long population tissue resident cells. A symbiotic relationship thought be maintained health whereby microbes maturation homeostasis, turn can engage TCR-dependent "tissue repair" program presence organisms conducive sustaining function integrity community. activation induced MR1-TCR dependent manner or through independent mechanisms

Язык: Английский

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Inflammatory bowel disease–associated intestinal fibrosis

Journal of Pathology and Translational Medicine, Год журнала: 2023, Номер 57(1), С. 60 - 66

Опубликована: Янв. 10, 2023

Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, this replacement organ tissue with fibrotic causes loss function. Inflammatory bowel disease (IBD) inflammation the gastrointestinal tract, intestinal fibrosis common in IBD patients, resulting several complications that require surgery, such as stricture or penetration. This review describes pathogenesis various factors involved IBD, including cytokines, growth factors, epithelial-mesenchymal endothelial-mesenchymal transitions, gut microbiota. Furthermore, histopathologic findings scoring systems used for stenosis are discussed, differences patterns ulcerative colitis Crohn's compared. Biomarkers therapeutic agents targeting briefly mentioned at end.

Язык: Английский

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