Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, Год журнала: 2023, Номер 12(1), С. 184 - 184

Опубликована: Янв. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Язык: Английский

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The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

Science Signaling, Год журнала: 2024, Номер 17(818)

Опубликована: Янв. 9, 2024

Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system describes a family dimeric transcription factors. Canonical NF-κB signaling stimulated and enhances inflammation, whereas noncanonical contributes to immune organogenesis. Dysregulation factors drives various inflammatory pathologies, including IBD. Signals from many sensors activate subunits intestine, which maintain equilibrium between local microbiota host responses. Genetic association studies patients with IBD preclinical mouse models confirm importance defense gut. Other have investigated roles these intestinal barrier function gut pathologies associated modulates innate adaptive responses production immunoregulatory proteins, anti-inflammatory cytokines, antimicrobial peptides, other tolerogenic intestine. Furthermore, genetic revealed critical cell type–specific for proteins homeostasis, restitution that contribute etiopathology IBD-associated manifestations. Here, we summarize our knowledge pathways, are activated different types specific ligands, their cross-talk, fueling aberrant inflammation. We argue in-depth understanding mechanisms may hold key identifying predictive or prognostic biomarkers developing better therapeutics against pathologies.

Язык: Английский

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The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis

Microorganisms, Год журнала: 2023, Номер 11(7), С. 1849 - 1849

Опубликована: Июль 21, 2023

The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance composition, can have profound effects on various aspects of human health, including susceptibility to viral infections. Despite numerous studies investigating the influence infections microbiome, impact dysbiosis infection pathogenesis remains relatively understudied. clinical variability observed SARS-CoV-2 seasonal influenza infections, presence natural HIV suppressors, suggests that host-intrinsic factors, may contribute pathogenesis. has been shown host system by regulating intestinal homeostasis through interactions with cells. This review aims enhance our understanding how perturb mucosal cells, affecting response Specifically, we focus exploring between gamma delta (γδ) T cells microbes context inflammatory examine highlighting disease outcomes. Furthermore, discuss emerging evidence potential future directions for modulation therapy

Язык: Английский

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Current and future perspectives for Helicobacter pylori treatment and management: From antibiotics to probiotics

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Ноя. 25, 2022

Helicobacter pylori ( H. ) is a Gram-negative anaerobic bacterium that colonizes the human stomach and leading cause of gastric diseases such as chronic gastritis peptic ulcers, well most definite controllable risk factor for development cancer. Currently, regimen eradication has changed from triple to quadruple, course treatment been extended, type dose antibiotics have adjusted, with limited improvement in efficacy but gradually increasing side effects repeated failures an number patients. In recent years, probiotics become one important tools supporting intestinal health immunity. Numerous vitro studies, animal clinical observations demonstrated advantage reducing rates adjuvant anti- therapy are valuable supplement conventional therapy. However, many different types used adjuncts against , various combinations, doses timing, quality studies varies, making it difficult standardize results. this paper, we focus on risk, status, prevention, control, infection review international consensus guidelines. We also summarize available scientific evidence using Limosilactobacillus reuteri (L. reuteri) critical probiotic discuss its research application evidence-based perspective.

Язык: Английский

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The role of the gut microbiota in gastric cancer: the immunoregulation and immunotherapy

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июнь 30, 2023

Gastric cancer (GC) is one of the most common cancers, leading to deaths millions people worldwide. Therefore, early detection and effective therapeutic strategies are great value for decreasing occurrence advanced GC. The human microbiota involved not only in maintenance physiological conditions, but also diseases such as obesity, diabetes, allergic atopic diseases, cancer. Currently, composition bacteria host, their functions, influence on disease progression treatment being discussed. Previous studies gut microbiome have mostly focused Helicobacter pylori (Hp) owing its significant role development Nevertheless, enrichment diversity other that can modulate tumor microenvironment GC efficacy immunotherapy. This review provides systematic insight into components application GC, including specific immunoregulatory effect, diagnostic value. Furthermore, we discuss relationship between metabolism microbes potential applications, which may serve a new approach diagnosis

Язык: Английский

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The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis

Trends in Microbiology, Год журнала: 2023, Номер 31(10), С. 1024 - 1043

Опубликована: Апрель 27, 2023

Язык: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250

Опубликована: Июль 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Язык: Английский

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The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

Biomedicines, Год журнала: 2022, Номер 10(12), С. 3117 - 3117

Опубликована: Дек. 2, 2022

The gastrointestinal (GI) tract is one of the most studied compartments human body as it hosts largest microbial community including trillions germs. relationship between and its associated flora complex, microbiome plays an important role in nutrition, metabolism immune function. With a dynamic composition, influenced by many intrinsic extrinsic factors, there equilibrium maintained composition GI microbiota, translated “eubiosis”. Any disruption microbiota leads to development different local systemic diseases. This article reviews microbiome’s function healthy individuals well involvement pathogenesis digestive disorders. It also highlights possibility consider manipulation therapeutic option when treating

Язык: Английский

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The role of microbiota in the development and treatment of gastric cancer

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Сен. 29, 2023

The stomach was once considered a sterile organ until the discovery of Helicobacter pylori (HP) . With application high-throughput sequencing technology and macrogenomics, researchers have identified fungi fivemajor bacterial phyla within stomachs healthy individuals. These microbial communities exert regulatory influence over various physiological functions, including energy metabolism immune responses. HP is well-recognized risk factor for gastric cancer, significantly altering stomach’s native microecology. Currently, numerous studies are centered on mechanisms by which contributes to cancer development, primarily involving CagA oncoprotein. However, aside from exogenous infections such as EBV, certain endogenous dysbiosis can also lead through multiple mechanisms. Additionally, gut microbiota its metabolites impact development cancer. role therapies, diet, phages, probiotics fecal transplantation, in treating should not be underestimated. This review aims study involved roles pathogen infection Also, we describe therapy treatment prognosis

Язык: Английский

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Co-administration of amoxicillin-loaded chitosan nanoparticles and inulin: A novel strategy for mitigating antibiotic resistance and preserving microbiota balance in Helicobacter pylori treatment

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126706 - 126706

Опубликована: Сен. 7, 2023

Язык: Английский

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