OBM Genetics,
Год журнала:
2024,
Номер
08(04), С. 1 - 25
Опубликована: Ноя. 20, 2024
Microbial
and
viral
pathogens
have
emerged
as
pivotal
agents
in
oncogenesis.
Research
conducted
the
last
twenty
years
has
significantly
enhanced
our
comprehension
of
cancer-causing
capabilities
infectious
agents.
An
illustrative
instance
is
gastric
cancer
(GC),
which
closely
associated
with
Helicobacter
pylori
(H.
pylori)
Epstein-Barr
virus
(EBV)
infections.
Despite
concerted
endeavors,
GC
remains
a
serious
clinical
challenge
ranking
fifth
most
commonly
diagnosed
worldwide.
In
2020,
an
estimated
768,793
people
died
from
world.
The
pathogenicity
island
(PAI),
cagA
protein,
VacA
other
virulence
factors
H.
several
latency
such
EBNA-1,
LMP-1
LMP2A
well
pattern
gene
methylation
EBV
co-infection
are
shown
main
causes
pathogen-related
GC.
unique
molecular
characteristics
GC,
highlight
importance
further
understanding
their
respective
roles
development
progression.
This
knowledge
may
inform
future
preventive
therapeutic
strategies
targeting
these
context
review
aims
to
elucidate
mechanisms
underpinning
pylori-induced
carcinogenesis
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 23, 2025
Gastric
cancer
remains
a
significant
global
health
challenge,
with
Helicobacter
pylori
(H.
pylori)
recognized
as
major
etiological
agent,
affecting
an
estimated
50%
of
the
world's
population.
There
has
been
rapidly
expanding
knowledge
molecular
and
pathogenetic
mechanisms
H.
over
decades.
This
review
summarizes
latest
research
advances
to
elucidate
underlying
infection
in
gastric
carcinogenesis.
Our
investigation
reveals
complex
network
involving
STAT3,
NF-κB,
Hippo,
Wnt/β-catenin
pathways,
which
are
dysregulated
caused
by
pylori.
Furthermore,
we
highlight
role
inducing
oxidative
stress,
DNA
damage,
chronic
inflammation,
cell
apoptosis—key
cellular
events
that
pave
way
for
Emerging
evidence
also
suggests
effect
on
tumor
microenvironment
its
possible
implications
immunotherapy.
synthesizes
current
identifies
gaps
warrant
further
investigation.
Despite
progress
our
previous
development
pylori-induced
cancer,
comprehensive
pylori's
is
crucial
advancement
prevention
treatment
strategies.
By
elucidating
these
mechanisms,
aim
provide
more
in-depth
insights
study
pylori-related
cancer.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 26, 2024
Helicobacter
pylori
(
H.
)
is
the
predominant
pathogen
causing
chronic
gastric
mucosal
infections
globally.
During
period
from
2011
to
2022,
global
prevalence
of
infection
was
estimated
at
43.1%,
while
in
China,
it
slightly
higher
approximately
44.2%.
Persistent
colonization
by
can
lead
gastritis,
peptic
ulcers,
and
malignancies
such
as
mucosa-associated
lymphoid
tissue
(MALT)
lymphomas
adenocarcinomas.
Despite
eliciting
robust
immune
responses
host,
thrives
mucosa
modulating
host
immunity,
particularly
altering
functions
innate
adaptive
cells,
dampening
inflammatory
adverse
its
survival,
posing
challenges
clinical
management.
The
interaction
between
defenses
intricate,
involving
evasion
recognition
modifying
surface
molecules,
manipulating
macrophage
functionality,
T
cell
evade
surveillance.
This
review
analyzes
immunopathogenic
mechanisms
,
underscoring
importance
identifying
new
therapeutic
targets
developing
effective
treatment
strategies,
discusses
how
development
vaccines
against
offers
hope
for
eradicating
infections.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 27, 2025
Helicobacter
pylori
is
a
gram-negative
microaerophilic
microorganism
intricately
associated
with
chronic
gastrointestinal
disorders
and
gastric
cancer.
H.
can
cause
various
upper
digestive
tract
diseases,
including
gastritis,
peptic
ulcer,
gastroesophageal
reflux
disease,
The
bacterium
exhibits
variety
of
pathogenic
mechanisms,
colonization,
the
expression
virulence
factors,
development
drug
resistance.
This
article
presents
comprehensive
review
pathogenesis,
emphasizing
recent
research
advancements
concerning
cytotoxin-associated
gene
A,
vacuolating
cytotoxin,
outer
membrane
proteins,
other
factors.
Additionally,
it
examines
molecular
mechanisms
underlying
resistance
evaluates
efficacy
conventional
therapeutic
approaches.
Recently,
researchers
have
attempted
novel
regimens,
probiotics
Chinese
medicine-assisted
therapies,
to
enhance
effects.
aimed
offer
an
overview
academic
community's
comprehension
infection
highlight
current
treatment
options.
Helicobacter
pylori
(H.
pylori)
colonizes
the
stomach
and
leads
to
secretion
of
a
vast
range
cytokines
by
infiltrated
leukocytes
directing
immune/inflammatory
response
against
bacterium.
To
regulate
responses,
suppressors
cytokine
signaling
(SOCS)
proteins
bind
multiple
components
located
downstream
receptors,
such
as
Janus
kinase
(JAK),
signal
transducers
activators
transcription
(STAT).
Dysfunctional
SOCS
in
immune
cells
may
facilitate
evasion
H.
pylori,
allowing
bacteria
induce
chronic
inflammation.
Dysregulation
expression
function
can
contribute
sustained
pylori-mediated
gastric
inflammation
which
lead
cancer
(GC)
development.
Among
molecules,
dysregulated
SOCS1,
SOCS2,
SOCS3,
SOCS6
were
indicated
pylori-infected
individuals
well
GC
tissues
cells.
pylori-induced
dysregulation
The
molecules
be
influenced
various
factors,
epigenetic
DNA
methylation,
noncoding
RNAs,
gene
polymorphisms.
Modulation
epithelial
considered
control
carcinogenesis
antitumor
respectively.
This
review
aimed
explain
interplay
between
development
induction
provide
insights
regarding
potential
therapeutic
strategies
modulating
molecules.
Abstract
Therapeutic
trends
involve
designing
ligands
to
target
proteins
in
various
diseases,
but
no
parallel
filters
have
been
established
prioritize
pathological
within
pathogens
for
optimal
inhibition.
This
study
unveils
that
order
a
protein
serve
as
an
therapeutic
intervention,
it
must
exhibit
five
key
attributes.
It
should
druggable
site
with
recognized
cleft
which
ligand
can
be
fitted
high
specificity.
possess
unique
structure,
distinct
sequences
having
low
similarity
other
non‐targeted
proteins.
dispensable
the
pathogenesis
of
disease,
and
case
microbial
infection,
crucial
survival
infectious
organisms.
available
crystallized
3D
structure
enable
high‐throughput
screening
candidate
ligands.
occupy
accessible
localization
provide
easy
route
reach
its
less
effort.
The
justifies
rules
essential
considering
ideal
any
protein‐mediated
dysfunction.
When
these
targeting
are
found
protein,
eradicating
intended
ailment
primarily
enhanced
time,
money,
ACS Omega,
Год журнала:
2025,
Номер
10(7), С. 6559 - 6566
Опубликована: Фев. 11, 2025
Nucleic
acid
tests
(NAT),
the
gold
standard
diagnostic
technology,
play
a
crucial
role
in
prevention
of
infectious
diseases.
However,
PCR,
current
state-of-the-art
NAT,
is
expensive,
slow,
and
requires
dedicated
infrastructure
facilities.
Therefore,
there
exists
an
urgent
need
to
create
alternative
molecular
technologies.
We
describe
use
colloidal
nanobiosensor
detection
system
that
can
specifically
sensitively
detect
16S
rRNA
gene
worldwide
gastric
pathogen
Helicobacter
pylori.
demonstrate
systematic
identification
oligonucleotide
probe
sequences
according
secondary
structure,
binding
energy,
homology
search
criteria.
selected
three
were
used
evaluate
120
nt
synthetic
analyte.
Detection
this
analyte
resulted
visual
color
change
solution
limit
(LOD)
10
nM
by
spectrophotometric
means
1
nM.
Furthermore,
we
demonstrated
could
clinical
samples
H.
pylori
with
LOD
5
×
105
copies/mL.
The
displayed
no
cross-reactivity
potentially
confounding
bacterial
pathogens.
Importantly,
also
ability
pyloriwithout
requirement
separate
DNA
extraction,
allowing
for
one-step
system.
In
summary,
have
created
simple-to-use,
economical,
rapid,
sensitive,
specific
PCR
be
useful
resource-limited
settings
control
spread
ABSTRACT
Introduction
Epidemiological
and
experimental
studies
have
suggested
that
chronic
H.
pylori
infection
may
be
associated
with
colorectal
cancer
(CRC),
a
topic
of
growing
interest.
The
Bradford‐Hill
criteria
are
the
mainstay
epidemiological
approach
to
causal
inference.
We
aim
evaluate
evidence
based
on
causality
association
between
CRC.
Methodology
A
literature
review
databases
search:
Pubmed,
ScienceDirect,
Embase,
SciELO,
Cochrane,
Medline.
There
no
limits
in
period.
Information
sources
were
coherent
objectives
set
selected.
Results
Applying
Bradford
Hill
criteria,
we
can
conclude
is
positively
current
findings
should
stimulate
future
explain
how
interacts
intestinal
dysbiosis
role
eradication
treatment
prevention
Conclusions
reasonably
meets
for
causality.
Further
required
consolidate
data
generate
strategies
determine
whether
translates
into
decreased
CRC
incidence
mortality
large
populations.
Helicobacter
pylori
infects
more
than
50%
of
the
human
population
worldwide.
Persistence
and
colonization
this
bacterium
in
host
result
genetic
epigenetic
alteration
intra-complicated
reactions
that
enhance
innate
adaptive
immune
responses,
which
lead
to
development
several
gastrointestinal
illnesses
increase
risk
for
gastric
cancer
progression.
Even
World
Health
Organization
(WHO)
classified
a
first
group
carcinogens;
also,
it
has
been
associated
with
multiple
extra
implications
such
as
autoimmune
disease
cardiovascular
disease,
thereby
being
considered
highly
infectious
pathogen
critical
health
problem
globally.
Detection
infection
facilitates
prognosis
suitable
treatment
enhances
eradication
prevent
further
implication.
The
aim
review
is
convey
aspects
related
infection,
understand
clarify
changes,
response,
pathogenicity
virulence
factors
involved
well
diagnostic
options,
fundamental
strategy
rate
reinfection
among
variable
individuals.
