The Journal of Physiology,
Год журнала:
2024,
Номер
602(15), С. 3621 - 3639
Опубликована: Июль 9, 2024
Growing
evidence
supports
the
role
of
gut
microbiota
in
chronic
inflammation,
insulin
resistance
(IR)
and
sex
hormone
production
polycystic
ovary
syndrome
(PCOS).
Adropin
plays
a
pivotal
regulation
glucose
lipid
metabolism
is
negatively
correlated
with
IR,
which
affects
intestinal
hormones.
However,
effect
adropin
administration
PCOS
has
yet
to
be
investigated.
The
present
study
aimed
assess
effects
on
letrozole
(LTZ)-induced
rats
potential
underlying
mechanisms.
experimental
groups
were
normal,
adropin,
LTZ
+
adropin.
At
end
experiment,
significantly
ameliorated
PCOS,
as
evidenced
by
restoring
normal
ovarian
structure,
decreasing
theca
cell
thickness
antral
follicles,
well
serum
testosterone
luteinizing
levels
hormone/follicle-stimulating
ratios,
at
same
time
increasing
granulosa
oestradiol
follicle-stimulating
levels.
ameliorating
could
attributed
its
hormone-binding
globulin,
key
steroidogenic
genes
STAR
CYP11A1,
profile,
metabolites-brain-ovary
axis
components
(short
chain
fatty
acids,
free
acid
receptor
3
peptide
YY),
permeability
marker
(zonulin
tight
junction
protein
claudin-1),
lipopolysaccharides/Toll-like
4/nuclear
factor
kappa
B
inflammatory
pathway
oxidative
stress
makers
(malondialdehyde
total
antioxidant
capacity).
In
conclusion,
promising
therapeutic
regulating
steroidogenesis,
redox
homeostasis.
KEY
POINTS:
treatment
reversed
endocrine
morphology
disorders
regulated
steroidogenesis
globulin
PCOS.
improved
profile
decreased
modulated
gut-brain-ovary
YY)
barrier
integrity,
suppressed
signalling
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(1), С. 24 - 24
Опубликована: Янв. 18, 2024
The
conceptualization
of
polycystic
ovary
syndrome
(PCOS)
has
primarily
focused
on
hormonal
alterations
driven
by
changes
within
the
hypothalamus
and
ovarian
granulosa
cells,
with
treatment
contraceptive
pill
weight
loss.
However,
a
growing
body
data
implicates
wider
systemic
central
nervous
system
(CNS)
in
pathoetiology
pathophysiology
PCOS,
consequent
implications
for
targeted
treatments.
It
is
proposed
that
there
significant
role
night-time
interactions
factors
acting
to
regulate
whether
rising
level
cortisol
over
night
during
morning
awakening
response
(CAR)
able
induce
nuclear
translocation
glucocorticoid
receptor
(GR),
thereby
influencing
how
immune
glial
systems
cellular
function
preparation
coming
day.
Factors
affording
protection
PCOS
also
inhibit
GR
including
gut
microbiome-derived
butyrate,
pineal/local
melatonin
as
well
regulated
bcl2-associated
athanogene
(BAG)-1.
A
pathophysiological
attributed
aryl
hydrocarbon
(AhR),
which
shows
heightened
levels
activity
PCOS.
AhR
activated
ligands
many
processes,
white
adipocyte-derived
kynurenine,
implicating
obesity
occurring
ovaries.
activation
consequences
physiological
hypothalamic
paraventricular
nucleus,
cells
adipocytes,
partly
mediated
upregulation
mitochondrial
N-acetylserotonin/melatonin
ratio,
decreasing
availability
whilst
increasing
local
stress
plasticity
nucleus.
This
article
reviews
detail
CNS
highlighting
pineal
melatonergic
pathway,
nucleus
tanycytes/astrocytes,
hypothalamus-pituitary-adrenal
(HPA)
axis
pathophysiology.
integrates
wide
array
previously
disparate
biological
underpinnings
associates
other
currently
classified
medical
conditions,
such
depression,
bipolar
disorder,
type
1
diabetes
mellitus
autism
spectrum.
Numerous
future
research
are
detailed.
Frontiers in Microbiomes,
Год журнала:
2024,
Номер
2
Опубликована: Март 26, 2024
Introduction
Previous
research
has
linked
vaginal
bacteria
to
polycystic
ovary
syndrome
(PCOS)
and
obesity
in
women,
yet
the
specific
disparities
microbiota
between
these
conditions
remain
unclear.
Methods
In
this
study,
we
aimed
elucidate
contribution
of
dysregulated
PCOS
by
analyzing
reproductive-aged
women
with
without
PCOS,
as
well
obese
non-obese
using
shotgun
sequencing.
Results
Swab
specimens
were
collected
from
four
groups
subjects:
obese,
non-obese,
non-PCOS
non-obese.
A
total
333
24
viruses/phages
identified
species
level.
Clustering
analysis
revealed
that
individuals
exhibit
a
similar
“healthy”
microbiome,
while
both
associated
microbial
dysbiosis.
Significant
differences
abundance
observed
for
26
bacterial
6
phages/viruses
groups.
Notably,
pathobionts
such
Streptococcus
pyogenes
,
Leptospira
santarosai
Citrobacter
amalonaticus
Listeria
ivanovii
Clostridium
perfringens
significantly
less
abundant
or
absent
group.
Furthermore,
Lactobacillus
Pseudomonas
bacteria,
their
corresponding
phages
exhibited
positive
correlations.
lactobacillus
phage,
pseudomonas
phage/virus
indicators
healthy
microbiome.
Importantly,
differentially
enriched
distinct.
Discussion
This
study
confirms
are
differing
enrichment
viruses/phages,
Moreover,
our
findings
suggest
phage
diversity
is
microbiota,
dysbiosis
decrease
alongside
increased
diversity.
Cells,
Год журнала:
2024,
Номер
13(14), С. 1171 - 1171
Опубликована: Июль 9, 2024
Androgen
excess
is
a
key
feature
of
several
clinical
phenotypes
polycystic
ovary
syndrome
(PCOS).
However,
the
presence
FSH
receptor
(FSHR)
and
aromatase
(CYP19A1)
activity
responses
to
physiological
endocrine
stimuli
play
critical
role
in
pathogenesis
PCOS.
Preliminary
data
suggest
that
myo-Inositol
(myo-Ins)
D-Chiro-Inositol
(D-Chiro-Ins)
may
reactivate
CYP19A1
activity.
We
investigated
steroidogenic
pathway
Theca
(TCs)
Granulosa
cells
(GCs)
an
experimental
model
murine
PCOS
induced
CD1
mice
exposed
for
10
weeks
continuous
light
regimen.
The
effect
treatment
with
different
combinations
myo-Ins
D-Chiro-Ins
on
expression
Fshr,
androgenic,
estrogenic
enzymes
was
analyzed
by
real-time
PCR
isolated
TCs
GCs
ovaries
from
healthy
mice.
Myo-Ins
D-Chiro-Ins,
at
ratio
40:1
pharmacological
concentrations,
positively
modulate
Cyp19a1
Fshr
GCs.
Moreover,
vivo,
inositols
(40:1
ratio)
significantly
increase
Fshr.
These
changes
gene
are
mirrored
modifications
hormone
levels
serum
treated
animals.
formula
efficiently
rescued
features
up-regulating
FSHR
while
down-regulating
androgen
excesses
produced
TCs.
The Journal of Physiology,
Год журнала:
2024,
Номер
602(15), С. 3621 - 3639
Опубликована: Июль 9, 2024
Growing
evidence
supports
the
role
of
gut
microbiota
in
chronic
inflammation,
insulin
resistance
(IR)
and
sex
hormone
production
polycystic
ovary
syndrome
(PCOS).
Adropin
plays
a
pivotal
regulation
glucose
lipid
metabolism
is
negatively
correlated
with
IR,
which
affects
intestinal
hormones.
However,
effect
adropin
administration
PCOS
has
yet
to
be
investigated.
The
present
study
aimed
assess
effects
on
letrozole
(LTZ)-induced
rats
potential
underlying
mechanisms.
experimental
groups
were
normal,
adropin,
LTZ
+
adropin.
At
end
experiment,
significantly
ameliorated
PCOS,
as
evidenced
by
restoring
normal
ovarian
structure,
decreasing
theca
cell
thickness
antral
follicles,
well
serum
testosterone
luteinizing
levels
hormone/follicle-stimulating
ratios,
at
same
time
increasing
granulosa
oestradiol
follicle-stimulating
levels.
ameliorating
could
attributed
its
hormone-binding
globulin,
key
steroidogenic
genes
STAR
CYP11A1,
profile,
metabolites-brain-ovary
axis
components
(short
chain
fatty
acids,
free
acid
receptor
3
peptide
YY),
permeability
marker
(zonulin
tight
junction
protein
claudin-1),
lipopolysaccharides/Toll-like
4/nuclear
factor
kappa
B
inflammatory
pathway
oxidative
stress
makers
(malondialdehyde
total
antioxidant
capacity).
In
conclusion,
promising
therapeutic
regulating
steroidogenesis,
redox
homeostasis.
KEY
POINTS:
treatment
reversed
endocrine
morphology
disorders
regulated
steroidogenesis
globulin
PCOS.
improved
profile
decreased
modulated
gut-brain-ovary
YY)
barrier
integrity,
suppressed
signalling
