Exploring Putative Causal Associations between Diet and Periodontal Disease Susceptibility

JDR Clinical & Translational Research, Год журнала: 2024, Номер unknown

Опубликована: Май 6, 2024

Introduction: Dietary factors may play an important role in periodontal health. However, current evidence from observational studies remains inconclusive. Objective: This study aimed to investigate the causal relationships between dietary exposures and disease risks using Mendelian randomization analysis. Methods: Large-scale genome-wide association summary statistics for 20 were obtained MRC-IEU consortium. Multivariable univariable 2-sample analyses performed assess effects of each exposure on 6 outcomes, including gingivitis periodontitis. Results: Genetically predicted higher dried fruit intake was significantly associated with reduced acute (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00–0.42; P = 0.01) bleeding gums (OR: 0.96; CI: 0.93–0.99; 0.01). Higher fresh water showed protective against chronic 0.18; 0.04–0.91; 0.04 OR: 0.15; 0.04–0.53; 0.00) 0.95; 0.92–0.981; 0.00 0.98; 0.96–0.99; 0.02). Alcohol frequency processed meat risk 1.01; 1.00–1.02; 0.01 1.05; 1.01–1.08; painful 1.00–1.01; 1.02; 1.01–1.03; 0.00). Most genetic predisposition specified diseases remained statistically significant (P < 0.05) after adjusting dentures, smoking, type 2 diabetes multivariable models. Conclusions: The findings suggest potential other problems, while alcohol increase disease. Our provides preliminary diet health could inform prevention strategies targeting habits improve oral Knowledge Transfer Statement: suggests that protect disease, meats risk, informing guidelines

Язык: Английский

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Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 16, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life victims. The prevalence AD has been increasing in recent years. Therefore, it great importance to elucidate pathogenic mechanism search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state gut microbiota, well known its involvement pathogenesis AD. Much effort made searching approaches capable modulating composition Herbal medicines have attracted extensive attention decades prevention treatment Here, we gave overview research progress on modulatory effects herbal formulae as possible beneficial AD, which may provide new insights into discovery anti-AD agents their potential through microbiota.

Язык: Английский

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Microglia-Associated Neuroinflammation in Alzheimer’s Disease and Its Therapeutic Potential

Neuroglia, Год журнала: 2024, Номер 5(4), С. 452 - 466

Опубликована: Ноя. 21, 2024

Background: Neuroinflammation has long been implicated in the progression of amyloid beta (Aβ) accumulation and decline cognitive function Alzheimer’s disease (AD). The phenotype balance between A1 (toxic) A2 (safe) microglial phenotypes to toxic illness AD become a hot research topic at present. Currently, many transcription factors, downstream signaling pathways, molecular mechanisms that regulate polarization microglia are being explored. Furthermore, may also exert complex role through transformation Aβ plaques or debris clearance, reflected phagocytosis. One mediators neuroinflammation is activated microglia. Therefore, regulation be key successfully treating AD. Methods: This paper review article. PubMed, Embase, Scopus, meeting abstracts were searched up 2024 for studies Disease. Systematic information retrieval was performed, appropriate isolated based on important available studies. from each articles understood extracted form database. Results: similar neuropathological results several animals cases show possibility implementing microglia-related changes as an earlier diagnostic marker humans. gene sets identified various transcriptomic further foster this avenue by offering potential targets therapeutic development. Substantial evidence, both vitro vivo, suggested loss normal activation contribute neurodegeneration Conclusions: Promoting restoring towards thus represent effective strategy ameliorating progressive neurocognitive impairments. Multiple suggest microglia-associated special stage could protective, and, therefore, intervention should delicate so beneficial response retained.

Язык: Английский

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Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Brain Sciences, Год журнала: 2023, Номер 13(12), С. 1632 - 1632

Опубликована: Ноя. 24, 2023

Studies in the field of experimental hypnosis highlighted role hypnotizability physiological variability general population. It is associated, fact, with a few differences which are observable ordinary state consciousness and absence suggestions. The aim present scoping review summarizing them indicate their relevance to neural mechanisms prognosis treatment medical conditions. Individuals high, medium low scores display different cerebral functional differences-i.e., equivalence between imagery perception/action, excitability motor cortex, interoceptive accuracy-possibly related brain structural characteristics, control blood supply at peripheral level, likely due availability endothelial nitric oxide. These reviewed support idea participation hypnotic behaviour prognostic therapeutic usefulness

Язык: Английский

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Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring

Frontiers in Pediatrics, Год журнала: 2023, Номер 11

Опубликована: Авг. 11, 2023

Porphyromonas gingivalis (P. gingivalis), a major periodontal pathogen, causes intrauterine infection/inflammation. Offspring exposed to infection/inflammation have an increased risk of neurological disorders, regardless gestational age. However, the relationship between maternal periodontitis and offspring functional/histological changes in brain has not yet been elucidated.In this study, we used mouse model investigate effects odontogenic infection P. on behavior tissue.The step-through passive avoidance test showed that latency acquisition trial was significantly shorter group (p < 0.05), but no difference spontaneous motor/exploratory parameters by open-field test. diffusely distributed throughout brain, especially hippocampus. In hippocampus amygdala, numbers neuron cells cyclic adenosine monophosphate response element binding protein-positive were reduced whereas number ionized calcium adapter protein 1-positive microglia 0.05). hippocampus, glial fibrillary acidic astrocytes also 0.05).The gingivalis-infected mothers cognitive function. Neurodegeneration/neuroinflammation amygdala may be caused infection, which is maternally transmitted. The importance eliminating gingivalis-odontogenic before or during gestation maintenance healthy function should addressed near future.

Язык: Английский

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Microglia-Associated Neuroinflammation in Alzheimer’s Disease

Опубликована: Июль 22, 2024

Background: Neuroinflammation has long been implicated in the progression of amyloid beta (Aβ) accumulation and decline cognitive function Alzheimer&#039;s disease (AD). Currently, many transcription factors, downstream signaling pathways, molecular mechanisms that regulate polarization microglia have explored. Furthermore, may also exert a complex role AD through transformation Aβ plaques or debris clearance, reflected phagocytosis. One mediators neuroinflammation is activated microglia. Therefore, regulation microglial be key to successfully treating AD. Methods: This review article. PubMed, Embase, Scopus, research meeting abstracts were searched up 2024 for studies Disease. Systematic information retrieval was performed appropriate isolated based on important available studies. The from each articles un-derstood extracted form database. Results: similar neuropathological results between several animals cases show possibility implement microglia-related changes as an earlier diagnostic marker humans. gene sets identified various transcriptomic further foster this avenue by offering potential targets therapeutic development. Multiple suggest microglia-associated at special stage could protective, there-fore, intervention should delicate so beneficial response retained. Conclusion: phenotype balance A1 (toxic) A2 (safe) phenotypes toxic illness become hot topic present. Substantial evidence, both vitro vivo, suggested loss normal activation contribute neurodegeneration Promoting restoring mi-croglia towards thus represent effective strategy ame-liorating progressive neurocognitive impairments.

Язык: Английский

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Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report

Genes, Год журнала: 2024, Номер 15(8), С. 1089 - 1089

Опубликована: Авг. 18, 2024

(1) Background: The study of the microbiome is crucial for its role in major systemic diseases, particular oral and gut microbiota. In recent years, microorganisms correlated, example, with neurodegenerative disease has increased prospect a possible link between microbiota brain. Here, we report new case concerning patient who was initially evaluated genetically dementia late-onset dyskinesia, later tested 16S metagenomics sequencing. (2) Methods: Starting from buccal swab, extracted bacterial DNA then performed NGS sequencing based on amplification hypervariable regions rRNA gene bacteria. (3) Results: revealed presence Spirochaetes phylum, pathogenic bacterium generally known to be capable migrating Central Nervous System. (4) Conclusions: Oral infections, as our results suggest, could contributing factors various conditions.

Язык: Английский

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The brain-gut axis: communication mechanisms and the role of the microbiome as a neuroprotective factor in the development of neurodegenerative diseases: A literature overview

AIMS neuroscience, Год журнала: 2024, Номер 11(3), С. 289 - 311

Опубликована: Янв. 1, 2024

<p>The study of the brain-gut axis and its impact on cognitive function in development neurodegenerative diseases is a very timely topic interest to researchers. This review summarizes information basic mechanisms gut-brain communication. We then discuss roles gut microbiome as neuroprotective factor neurodegeneration. The microbiota extremely important maintaining body's homeostasis, shaping human immune system proper functioning brain. intestinal microflora affects processes neuroplasticity, synaptogenesis, neuronal regeneration. aims explain changes composition bacterial population among patients with Alzheimer's disease, Parkinson's multiple sclerosis. Abnormalities are also noted stress, depression, or autism spectrum development. New observations psychobiotic supplementation alleviating symptoms presented.</p>

Язык: Английский

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β-Amyloids and Immune Responses Associated with Alzheimer’s Disease

Cells, Год журнала: 2024, Номер 13(19), С. 1624 - 1624

Опубликована: Сен. 28, 2024

Alzheimer’s disease (AD) is associated with the accumulation of β-amyloids (Aβs) and formation Aβ plaques in brain. Various structural forms isoforms Aβs that have variable propensities for oligomerization toxicity may differentially affect development AD been identified. In addition, there evidence are engaged complex interactions innate adaptive immune systems, both which also play a role regulation onset progression. this review, we discuss what currently known about intricate interplay between response to more in-depth focus on possible roles B cells pathogenesis AD.

Язык: Английский

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Physiological Correlates of Hypnotizability: Neural Mechanisms of Hypnosis and Prognostic Role in Medicine

Опубликована: Сен. 28, 2023

Studies in the field of experimental hypnosis highlighted role hypnotizability physiological variability general population. It is associated, fact, with a few differences which are observable ordinary state consciousness and absence suggestions. The aim present scoping review summarizing them, indicate their relevance to neural mechanisms prognosis treatment medical conditions. Individuals high, medium low scores display different cerebral functional – i.e., equivalence between imagery perception/action , excitability motor cortex, interoceptive accuracy - possibly related brain structural characteristics control blood supply at peripheral level, likely due availability endothelial nitric oxide. These reviewed support idea participation hypnotic behaviour prognostic therapeutic usefulness

Язык: Английский

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