Studies
in
the
field
of
experimental
hypnosis
highlighted
role
hypnotizability
physiological
variability
general
population.
It
is
associated,
fact,
with
a
few
differences
which
are
observable
ordinary
state
consciousness
and
absence
suggestions.
The
aim
present
scoping
review
summarizing
them,
indicate
their
relevance
to
neural
mechanisms
prognosis
treatment
medical
conditions.
Individuals
high,
medium
low
scores
display
different
cerebral
functional
–
i.e.,
equivalence
between
imagery
perception/action,
excitability
motor
cortex,
interoceptive
accuracy
-
possibly
related
brain
structural
characteristics
-,
control
blood
supply
at
peripheral
level,
likely
due
availability
endothelial
nitric
oxide.
These
reviewed
support
idea
participation
hypnotic
behaviour
prognostic
therapeutic
usefulness
Neuroglia,
Journal Year:
2024,
Volume and Issue:
5(4), P. 452 - 466
Published: Nov. 21, 2024
Background:
Neuroinflammation
has
long
been
implicated
in
the
progression
of
amyloid
beta
(Aβ)
accumulation
and
decline
cognitive
function
Alzheimer’s
disease
(AD).
The
phenotype
balance
between
A1
(toxic)
A2
(safe)
microglial
phenotypes
to
toxic
illness
AD
become
a
hot
research
topic
at
present.
Currently,
many
transcription
factors,
downstream
signaling
pathways,
molecular
mechanisms
that
regulate
polarization
microglia
are
being
explored.
Furthermore,
may
also
exert
complex
role
through
transformation
Aβ
plaques
or
debris
clearance,
reflected
phagocytosis.
One
mediators
neuroinflammation
is
activated
microglia.
Therefore,
regulation
be
key
successfully
treating
AD.
Methods:
This
paper
review
article.
PubMed,
Embase,
Scopus,
meeting
abstracts
were
searched
up
2024
for
studies
Disease.
Systematic
information
retrieval
was
performed,
appropriate
isolated
based
on
important
available
studies.
from
each
articles
understood
extracted
form
database.
Results:
similar
neuropathological
results
several
animals
cases
show
possibility
implementing
microglia-related
changes
as
an
earlier
diagnostic
marker
humans.
gene
sets
identified
various
transcriptomic
further
foster
this
avenue
by
offering
potential
targets
therapeutic
development.
Substantial
evidence,
both
vitro
vivo,
suggested
loss
normal
activation
contribute
neurodegeneration
Conclusions:
Promoting
restoring
towards
thus
represent
effective
strategy
ameliorating
progressive
neurocognitive
impairments.
Multiple
suggest
microglia-associated
special
stage
could
protective,
and,
therefore,
intervention
should
delicate
so
beneficial
response
retained.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 24, 2023
Studies
in
the
field
of
experimental
hypnosis
highlighted
role
hypnotizability
physiological
variability
general
population.
It
is
associated,
fact,
with
a
few
differences
which
are
observable
ordinary
state
consciousness
and
absence
suggestions.
The
aim
present
scoping
review
summarizing
them
indicate
their
relevance
to
neural
mechanisms
prognosis
treatment
medical
conditions.
Individuals
high,
medium
low
scores
display
different
cerebral
functional
differences-i.e.,
equivalence
between
imagery
perception/action,
excitability
motor
cortex,
interoceptive
accuracy-possibly
related
brain
structural
characteristics,
control
blood
supply
at
peripheral
level,
likely
due
availability
endothelial
nitric
oxide.
These
reviewed
support
idea
participation
hypnotic
behaviour
prognostic
therapeutic
usefulness
Frontiers in Pediatrics,
Journal Year:
2023,
Volume and Issue:
11
Published: Aug. 11, 2023
Porphyromonas
gingivalis
(P.
gingivalis),
a
major
periodontal
pathogen,
causes
intrauterine
infection/inflammation.
Offspring
exposed
to
infection/inflammation
have
an
increased
risk
of
neurological
disorders,
regardless
gestational
age.
However,
the
relationship
between
maternal
periodontitis
and
offspring
functional/histological
changes
in
brain
has
not
yet
been
elucidated.In
this
study,
we
used
mouse
model
investigate
effects
odontogenic
infection
P.
on
behavior
tissue.The
step-through
passive
avoidance
test
showed
that
latency
acquisition
trial
was
significantly
shorter
group
(p
<
0.05),
but
no
difference
spontaneous
motor/exploratory
parameters
by
open-field
test.
diffusely
distributed
throughout
brain,
especially
hippocampus.
In
hippocampus
amygdala,
numbers
neuron
cells
cyclic
adenosine
monophosphate
response
element
binding
protein-positive
were
reduced
whereas
number
ionized
calcium
adapter
protein
1-positive
microglia
0.05).
hippocampus,
glial
fibrillary
acidic
astrocytes
also
0.05).The
gingivalis-infected
mothers
cognitive
function.
Neurodegeneration/neuroinflammation
amygdala
may
be
caused
infection,
which
is
maternally
transmitted.
The
importance
eliminating
gingivalis-odontogenic
before
or
during
gestation
maintenance
healthy
function
should
addressed
near
future.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 16, 2024
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
memory
loss
and
cognitive
impairment.
It
severely
affects
the
quality
of
life
victims.
The
prevalence
AD
has
been
increasing
in
recent
years.
Therefore,
it
great
importance
to
elucidate
pathogenic
mechanism
search
for
effective
therapeutic
approaches.
Gut
microbiota
dysbiosis,
an
altered
state
gut
microbiota,
well
known
its
involvement
pathogenesis
AD.
Much
effort
made
searching
approaches
capable
modulating
composition
Herbal
medicines
have
attracted
extensive
attention
decades
prevention
treatment
Here,
we
gave
overview
research
progress
on
modulatory
effects
herbal
formulae
as
possible
beneficial
AD,
which
may
provide
new
insights
into
discovery
anti-AD
agents
their
potential
through
microbiota.
Background:
Neuroinflammation
has
long
been
implicated
in
the
progression
of
amyloid
beta
(Aβ)
accumulation
and
decline
cognitive
function
Alzheimer's
disease
(AD).
Currently,
many
transcription
factors,
downstream
signaling
pathways,
molecular
mechanisms
that
regulate
polarization
microglia
have
explored.
Furthermore,
may
also
exert
a
complex
role
AD
through
transformation
Aβ
plaques
or
debris
clearance,
reflected
phagocytosis.
One
mediators
neuroinflammation
is
activated
microglia.
Therefore,
regulation
microglial
be
key
to
successfully
treating
AD.
Methods:
This
review
article.
PubMed,
Embase,
Scopus,
research
meeting
abstracts
were
searched
up
2024
for
studies
Disease.
Systematic
information
retrieval
was
performed
appropriate
isolated
based
on
important
available
studies.
The
from
each
articles
un-derstood
extracted
form
database.
Results:
similar
neuropathological
results
between
several
animals
cases
show
possibility
implement
microglia-related
changes
as
an
earlier
diagnostic
marker
humans.
gene
sets
identified
various
transcriptomic
further
foster
this
avenue
by
offering
potential
targets
therapeutic
development.
Multiple
suggest
microglia-associated
at
special
stage
could
protective,
there-fore,
intervention
should
delicate
so
beneficial
response
retained.
Conclusion:
phenotype
balance
A1
(toxic)
A2
(safe)
phenotypes
toxic
illness
become
hot
topic
present.
Substantial
evidence,
both
vitro
vivo,
suggested
loss
normal
activation
contribute
neurodegeneration
Promoting
restoring
mi-croglia
towards
thus
represent
effective
strategy
ame-liorating
progressive
neurocognitive
impairments.
Genes,
Journal Year:
2024,
Volume and Issue:
15(8), P. 1089 - 1089
Published: Aug. 18, 2024
(1)
Background:
The
study
of
the
microbiome
is
crucial
for
its
role
in
major
systemic
diseases,
particular
oral
and
gut
microbiota.
In
recent
years,
microorganisms
correlated,
example,
with
neurodegenerative
disease
has
increased
prospect
a
possible
link
between
microbiota
brain.
Here,
we
report
new
case
concerning
patient
who
was
initially
evaluated
genetically
dementia
late-onset
dyskinesia,
later
tested
16S
metagenomics
sequencing.
(2)
Methods:
Starting
from
buccal
swab,
extracted
bacterial
DNA
then
performed
NGS
sequencing
based
on
amplification
hypervariable
regions
rRNA
gene
bacteria.
(3)
Results:
revealed
presence
Spirochaetes
phylum,
pathogenic
bacterium
generally
known
to
be
capable
migrating
Central
Nervous
System.
(4)
Conclusions:
Oral
infections,
as
our
results
suggest,
could
contributing
factors
various
conditions.
AIMS neuroscience,
Journal Year:
2024,
Volume and Issue:
11(3), P. 289 - 311
Published: Jan. 1, 2024
<p>The
study
of
the
brain-gut
axis
and
its
impact
on
cognitive
function
in
development
neurodegenerative
diseases
is
a
very
timely
topic
interest
to
researchers.
This
review
summarizes
information
basic
mechanisms
gut-brain
communication.
We
then
discuss
roles
gut
microbiome
as
neuroprotective
factor
neurodegeneration.
The
microbiota
extremely
important
maintaining
body's
homeostasis,
shaping
human
immune
system
proper
functioning
brain.
intestinal
microflora
affects
processes
neuroplasticity,
synaptogenesis,
neuronal
regeneration.
aims
explain
changes
composition
bacterial
population
among
patients
with
Alzheimer's
disease,
Parkinson's
multiple
sclerosis.
Abnormalities
are
also
noted
stress,
depression,
or
autism
spectrum
development.
New
observations
psychobiotic
supplementation
alleviating
symptoms
presented.</p>
Cells,
Journal Year:
2024,
Volume and Issue:
13(19), P. 1624 - 1624
Published: Sept. 28, 2024
Alzheimer’s
disease
(AD)
is
associated
with
the
accumulation
of
β-amyloids
(Aβs)
and
formation
Aβ
plaques
in
brain.
Various
structural
forms
isoforms
Aβs
that
have
variable
propensities
for
oligomerization
toxicity
may
differentially
affect
development
AD
been
identified.
In
addition,
there
evidence
are
engaged
complex
interactions
innate
adaptive
immune
systems,
both
which
also
play
a
role
regulation
onset
progression.
this
review,
we
discuss
what
currently
known
about
intricate
interplay
between
response
to
more
in-depth
focus
on
possible
roles
B
cells
pathogenesis
AD.
Archives of Current Research International,
Journal Year:
2024,
Volume and Issue:
24(5), P. 557 - 582
Published: June 11, 2024
Aim:
The
aim
of
this
study
was
to
review
the
literature
in
an
integrative
way,
looking
for
scientific
evidence
see
if
there
is
a
relationship
between
periodontal
disease
(PD)
and
Alzheimer's
(AD).
Study
Design:
Review
integrative.
Methodology:
search
carried
out
on
VHL
Regional
Portal
with
articles
published
English,
Spanish
Portuguese.
169
were
found
2021
2023.
Of
total,
106
excluded,
5
being
duplicates
101
not
meeting
inclusion
criteria.
studies
analyzed,
most
report
association
PD
AD,
Phorphyromonas
gingivalis
(PG)
as
common
pathogen
both
conditions.
Results:
results
revealed
four
aspects:
a)
PG
other
periodontopathogens
(PP)
play
role
systemic
inflammation
process
that
accelerates
onset
progression
AD;
b)
even
given
link
oral-brain
aetiological
axis
hypothesis
brain
degeneration
syndrome
such
it
still
necessary
further
investigate
PP
(multimicrobial
hypothesis)
pathogenesis
worsening
c)
represents
factor
AD
via
induced
pathogenic
bacteria,
since
these
individuals
may
have
poor
oral
hygiene
care,
due
forgetfulness
or
less
manual
dexterity;
d)
Age
gender
are
important
variables
consider
when
assessing
AD.
Conclusion:
Thus,
we
can
infer
despite
number
observed
through
review,
enough
research
high
level
association.
new
greater
methodological
rigor
terms
methods
applied
criteria
diagnosing
pathologies
need
be
order
obtain
better
understanding
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 25, 2024
Abstract
The
gut
microbiota
plays
a
pivotal
role
in
human
health
by
modulating
physiological
homeostasis
and
influencing
the
pathogenesis
of
various
diseases.
Recent
studies
have
underscored
close
relationship
between
neurotransmitters,
which
act
as
communication
mediators
brain,
development
treatment
multiple
brain
disorders.
Despite
these
advances,
intricate
interactions
diseases
remain
largely
unexplored
extensive
biomedical
literature.
There
is
notable
absence
structured
database
focusing
on
microbiota-brain
disease
associations.
Introducing
BGMDB
(Brain
Disease
Gut
Microbiota
Database),
meticulously
curated
designed
to
provide
experimentally
supported
connections
current
version
extensively
covers
1,419
associations
involving
609
43
diseases,
including
184
specific
association
triplets
linking
among
six
neurotransmitters.
Noteworthy
that
integrates
gene
data
related
from
gutMGene
database.
Brain
region
microbial
networks
are
introduced
investigate
potential
common
genetic
relationships
changes.
Each
entry
offers
detailed
insights
into
associations,
particular
implicated,
involved
microbiota,
neurotransmitter,
concise
description
relevant
literature
references.
To
facilitate
easier
access
information
for
provides
enhanced
graphical
query
options
address
biologically
pertinent
inquiries.
Additionally,
user-friendly
interface
allows
users
browse,
retrieve,
download
entries
conveniently.
serves
valuable
resource
investigating
microbes
associated
with
Access
through
http://43.139.38.118:8080/demo02/
.
