Brain-derived neurotrophic factor – a key player in the gastrointestinal system

Gastroenterology Review, Год журнала: 2023, Номер 18(4), С. 380 - 392

Опубликована: Янв. 1, 2023

AMA Singh A. Brain-derived neurotrophic factor – a key player in the gastrointestinal system. Gastroenterology Review/Przegląd Gastroenterologiczny. 2023. doi:10.5114/pg.2023.132957. APA Singh, (2023). https://doi.org/10.5114/pg.2023.132957 Chicago Arjun. "Brain-derived system". Harvard MLA system." Gastroenterologiczny, Vancouver

Язык: Английский

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The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 24, 2024

Depression manifests as a mental disorder characterized by low mood, suicidal tendencies, disturbances in sleep-wake cycles, psychomotor agitation, and pronounced feelings of hopelessness anhedonia. Baicalin, natural flavonoid compound, shows significant promise alleviating depressive symptoms animals. This study aims to assess the impact baicalin on experimental models depression.

Язык: Английский

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Ganjiang Huangqin Huanglian Renshen Decoction Protects Against Ulcerative Colitis by Modulating Inflammation, Oxidative Stress, and Gut Microbiota

Phytomedicine, Год журнала: 2024, Номер 135, С. 156172 - 156172

Опубликована: Окт. 22, 2024

Ulcerative colitis (UC) is a disease that difficult to treat and has been associated with high rates of recurrence. Moreover, the current medications for UC induce serious side effects following prolonged use. Ganjiang Huangqin Huanglian Renshen Decoction (GJHQHLRSD), traditionally used UC. However, its protective mechanisms have not fully studied.

Язык: Английский

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Narrative Review: Pathogenesis of the Inflammatory Response and Intestinal Flora in Depression

Neuropsychiatric Disease and Treatment, Год журнала: 2023, Номер Volume 19, С. 2469 - 2483

Опубликована: Ноя. 1, 2023

Depression, as a common mental illness that is often accompanied by suicidal and homicidal behaviors, one of the most important diseases in medical field requires urgent attention. The pathogenesis depression complex, current therapeutic drugs such tricyclic antidepressants (TCAs), monoamine oxidase inhibitors, secondary serotonin reuptake inhibitors have certain shortcomings. inflammatory factor hypothesis, depression, suggests response key leading to occurrence development overactivation factors NLRP3, Toll-like receptor 4, IDO leads immune-system dysfunction depression. other pathogenic gut flora has also been focus recent research. may work together with cause approach treating altering through or probiotics. However, effective clear treatment methods are lacking. In this study, exploring involvement intestinal we found improving can affect and, therefore, provide research ideas for novel treat

Язык: Английский

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Unraveling the potential of Morinda officinalis oligosaccharides as an adjuvant of escitalopram in depression treatment and exploring the underlying mechanisms

Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118124 - 118124

Опубликована: Март 29, 2024

Язык: Английский

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Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6695 - 6695

Опубликована: Июнь 18, 2024

Light pollution is a potential risk for intestinal health in humans and animals. The gut microbiota associated with the development of inflammation induced by extended exposure to light, but underlying mechanism not yet clear. results this study showed that light (18L:6D) damaged morphology, downregulated expression tight junction proteins, upregulated NLRP3 inflammasome concentration pro-inflammatory cytokines. In addition, significantly decreased abundance Lactobacillus, Butyricicoccus, Sellimonas increased Bifidobacterium, unclassified Oscillospirales, Family_XIII_UCG-001, norank_f__norank_o__Clostridia_vadinBB60_group, Defluviitaleaceae_UCG-01. Spearman correlation analysis indicated dysbiosis positively correlated activation inflammasome. above injury dysbiosis. Antibiotic depletion treatment cecal transplantation (CMT) from 12L:12D group 18L:6D alleviated inflammatory via inhibiting conclusion, our findings can alleviate

Язык: Английский

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Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors

Advances in pharmacology, Год журнала: 2024, Номер unknown, С. 103 - 157

Опубликована: Ноя. 8, 2024

Язык: Английский

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