Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors DOI
Baljit Kaur,

Savannah Biby,

Jannatun Nayem Namme

et al.

Advances in pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 103 - 157

Published: Nov. 8, 2024

Language: Английский

Brain-derived neurotrophic factor – a key player in the gastrointestinal system DOI Creative Commons
Arjun Singh

Gastroenterology Review, Journal Year: 2023, Volume and Issue: 18(4), P. 380 - 392

Published: Jan. 1, 2023

AMA Singh A. Brain-derived neurotrophic factor – a key player in the gastrointestinal system. Gastroenterology Review/Przegląd Gastroenterologiczny. 2023. doi:10.5114/pg.2023.132957. APA Singh, (2023). https://doi.org/10.5114/pg.2023.132957 Chicago Arjun. "Brain-derived system". Harvard MLA system." Gastroenterologiczny, Vancouver

Language: Английский

Citations

5
The effects of baicalin in depression: preclinical evidence construction based on meta-analysis DOI Creative Commons

Dan Wang,

Yu-Meng Ren,

Yixuan Guo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Depression manifests as a mental disorder characterized by low mood, suicidal tendencies, disturbances in sleep-wake cycles, psychomotor agitation, and pronounced feelings of hopelessness anhedonia. Baicalin, natural flavonoid compound, shows significant promise alleviating depressive symptoms animals. This study aims to assess the impact baicalin on experimental models depression.

Language: Английский

Citations

1
Ganjiang Huangqin Huanglian Renshen Decoction Protects Against Ulcerative Colitis by Modulating Inflammation, Oxidative Stress, and Gut Microbiota DOI Creative Commons
Ce Zhou, Bo Peng, Mingxing Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156172 - 156172

Published: Oct. 22, 2024

Ulcerative colitis (UC) is a disease that difficult to treat and has been associated with high rates of recurrence. Moreover, the current medications for UC induce serious side effects following prolonged use. Ganjiang Huangqin Huanglian Renshen Decoction (GJHQHLRSD), traditionally used UC. However, its protective mechanisms have not fully studied.

Language: Английский

Citations

1
Narrative Review: Pathogenesis of the Inflammatory Response and Intestinal Flora in Depression DOI Creative Commons
Jia-Wei Zeng,

Juan-Li Zhao,

Zhenjie Han

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 2469 - 2483

Published: Nov. 1, 2023

Depression, as a common mental illness that is often accompanied by suicidal and homicidal behaviors, one of the most important diseases in medical field requires urgent attention. The pathogenesis depression complex, current therapeutic drugs such tricyclic antidepressants (TCAs), monoamine oxidase inhibitors, secondary serotonin reuptake inhibitors have certain shortcomings. inflammatory factor hypothesis, depression, suggests response key leading to occurrence development overactivation factors NLRP3, Toll-like receptor 4, IDO leads immune-system dysfunction depression. other pathogenic gut flora has also been focus recent research. may work together with cause approach treating altering through or probiotics. However, effective clear treatment methods are lacking. In this study, exploring involvement intestinal we found improving can affect and, therefore, provide research ideas for novel treat

Language: Английский

Citations

2
Unraveling the potential of Morinda officinalis oligosaccharides as an adjuvant of escitalopram in depression treatment and exploring the underlying mechanisms DOI
Shu‐Man Pan,

Xuyuan Yin,

D. N. Dai

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118124 - 118124

Published: March 29, 2024

Language: Английский

Citations

0
Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens DOI Open Access

Dandan Ma,

Min-Hong Zhang,

Jinghai Feng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6695 - 6695

Published: June 18, 2024

Light pollution is a potential risk for intestinal health in humans and animals. The gut microbiota associated with the development of inflammation induced by extended exposure to light, but underlying mechanism not yet clear. results this study showed that light (18L:6D) damaged morphology, downregulated expression tight junction proteins, upregulated NLRP3 inflammasome concentration pro-inflammatory cytokines. In addition, significantly decreased abundance Lactobacillus, Butyricicoccus, Sellimonas increased Bifidobacterium, unclassified Oscillospirales, Family_XIII_UCG-001, norank_f__norank_o__Clostridia_vadinBB60_group, Defluviitaleaceae_UCG-01. Spearman correlation analysis indicated dysbiosis positively correlated activation inflammasome. above injury dysbiosis. Antibiotic depletion treatment cecal transplantation (CMT) from 12L:12D group 18L:6D alleviated inflammatory via inhibiting conclusion, our findings can alleviate

Language: Английский

Citations

0
Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors DOI
Baljit Kaur,

Savannah Biby,

Jannatun Nayem Namme

et al.

Advances in pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 103 - 157

Published: Nov. 8, 2024

Language: Английский

Citations

0