Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 815 - 815
Опубликована: Апрель 3, 2025
As
an
important
intestinal
microorganism,
Odoribacter
splanchnicus
frequently
appears
in
high-throughput
sequencing
analyses,
although
pure
culture
research
on
this
microorganism
is
not
as
advanced.
It
widely
present
the
mammalian
gut
and
closely
associated
with
health
status
of
host
incidence
various
diseases.
In
recent
years,
changes
abundance
O.
have
been
found
to
be
positively
or
negatively
correlated
issues,
such
obesity,
metabolic
syndrome,
diabetes,
inflammation.
may
exhibit
a
dual
protective
promotional
role
specific
Thus,
it
play
regulating
metabolism,
immune
response,
homeostasis.
Additional
has
revealed
that
can
synthesize
metabolites,
especially
short-chain
fatty
acids
(SCFAs),
which
key
promoting
health,
enhancing
energy
improving
insulin
resistance,
responses
host.
Therefore,
strong
candidate
for
“next-generation
probiotics”,
its
potential
probiotic
function
provides
novel
ideas
development
functional
foods
prevention
treatment
inflammatory
These
findings
help
develop
new
biological
strategies
optimize
management
plans.
Nutrients,
Год журнала:
2024,
Номер
16(3), С. 412 - 412
Опубликована: Янв. 31, 2024
Alzheimer’s
disease
(AD),
the
most
prevalent
form
of
dementia,
is
characterized
by
accumulation
amyloid-beta
(Aβ)
plaques
and
hyperphosphorylated
tau
tangles.
Currently,
(AD)
impacts
50
million
individuals,
with
projections
anticipating
an
increase
to
152
year
2050.
Despite
increasing
global
prevalence
AD,
its
underlying
pathology
remains
poorly
understood,
posing
challenges
for
early
diagnosis
treatment.
Recent
research
suggests
a
link
between
gut
dysbiosis
aggregation
Aβ,
development
proteins,
occurrence
neuroinflammation
oxidative
stress
are
associated
AD.
However,
investigations
into
gut–brain
axis
(GBA)
in
context
AD
progression
have
yielded
inconsistent
findings.
This
review
aims
enhance
our
understanding
microbial
diversity
at
species
level
role
these
pathology.
Additionally,
this
addresses
influence
confounding
elements,
including
diet,
probiotics,
prebiotics,
on
throughout
different
stages
(preclinical,
mild
cognitive
impairment
(MCI),
AD)
progression.
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4365 - 4365
Опубликована: Окт. 13, 2023
This
systematic
review
aims
to
provide
a
comprehensive
understanding
of
the
current
literature
regarding
gut
microbiota
composition
in
patients
with
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD)
compared
healthy
controls.
To
identify
relevant
studies,
thorough
search
PubMed,
Medline,
Embase
was
conducted
following
PRISMA
guidelines.
Out
5627
articles,
73
studies
were
assessed
for
full-text
eligibility,
which
led
inclusion
42
(26
PD
16
AD
studies).
The
risk
bias
assessment
showed
medium
32
(20
12
studies),
low
9
(5
4
1
study
high
risk.
Among
22
out
26
reported
different
between
cases
controls,
15
differences
consistently
identified
phyla
Bacteroidetes,
Firmicutes,
Proteobacteria
as
prevalent
both
groups
case
groups.
Microbial
dysbiosis
specifically
characterized
by
abundance
Akkermansia,
Verrucomicrobiaceae,
Lachnospiraceae,
Ruminococcaceae
Blautia,
Coprococcus,
Prevotellaceae,
Roseburia
Similarly,
Bacteroides
Acidobacteriota
abundant
cases,
Acidaminococcaceae,
Ruminiclostridium
microbial
signature
association
several
taxa,
including
Bifidobacterium,
Ruminococcacea,
Verrucomicrobia
Ruminococcaceae,
Bacteroides,
Actinobacteria
AD.
diversity
evaluations
indicated
comparable
alpha
some
distinct
others,
consistent
beta
controls
across
multiple
studies.
bacterial
signatures
this
that
are
associated
may
offer
promising
prospects
efficient
management
treatment
approaches.
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 308 - 308
Опубликована: Янв. 19, 2024
Many
researchers
propose
manipulating
microbiota
to
prevent
and
treat
related
diseases.
The
brain-gut
axis
is
an
object
that
remains
the
target
of
modern
research,
it
not
without
reason
many
enrich
with
diet
in
its
name.
Numerous
connections
mutual
correlations
have
become
basis
for
seeking
answers
questions
pathology
as
well
human
physiology.
Disorders
this
homeostasis
dysbiosis
itself
accompany
neurodegenerative
diseases
such
Alzheimer's
Parkinson's.
Heavily
dependent
on
external
factors,
modulation
gut
microbiome
represents
opportunity
advance
treatment
Probiotic
interventions,
synbiotic
or
fecal
transplantation
can
undoubtedly
support
biotherapeutic
process.
A
special
role
played
by
diet,
which
provides
metabolites
directly
affect
body
microbiota.
holistic
view
organism
therefore
essential.
Abstract
The
qualified
presumption
of
safety
(QPS)
process
was
developed
to
provide
a
assessment
approach
for
microorganisms
intended
use
in
food
or
feed
chains.
In
the
period
covered
by
this
statement,
no
new
information
found
that
would
change
status
previously
recommended
QPS
TUs.
TUs
list
were
updated
based
on
verification,
against
their
respective
authoritative
databases,
correctness
names
and
completeness
synonyms.
A
procedure
has
been
established
ensure
are
kept
up
date
relation
recent
taxonomical
insights.
Of
83
notified
EFSA
between
October
2023
March
2024
(47
as
additives,
25
enzymes
11
novel
foods),
75
not
evaluated
because:
15
filamentous
fungi,
1
Enterococcus
faecium,
10
Escherichia
coli,
Streptomyces
(all
excluded
from
evaluation)
48
already
have
status.
Two
other
eight
notifications
possible
previous
Panel
Statement:
Heyndrickxia
faecalis
(previously
Weizmannia
faecalis)
Serratia
marcescens.
One
at
genus
level
so
could
be
assessed
five
belonging
Akkermansia
muciniphila
Actinomadura
roseirufa
still
due
concerns.
Rhizobium
radiobacter
can
with
qualification
production
purposes.
Microbacterium
arborescens
Burkholderia
stagnalis
cannot
included
lack
body
knowledge
its
chain
B.
also
A.
further
assessment.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1695 - 1695
Опубликована: Май 29, 2024
This
comprehensive
review
delineates
the
extensive
roles
of
Akkermansia
muciniphila
in
various
health
domains,
spanning
from
metabolic
and
inflammatory
diseases
to
neurodegenerative
disorders.
A.
muciniphila,
known
for
its
ability
reside
mucous
layer
intestine,
plays
a
pivotal
role
maintaining
gut
integrity
interacting
with
host
processes.
Its
influence
extends
modulating
immune
responses
potentially
easing
symptoms
across
several
non-communicable
diseases,
including
obesity,
diabetes,
bowel
disease,
cancer.
Recent
studies
highlight
capacity
interact
gut–brain
axis,
suggesting
possible
impact
on
neuropsychiatric
conditions.
Despite
promising
therapeutic
potential
highlighted
animal
preliminary
human
studies,
challenges
remain
practical
application
due
stability
cultivation
issues.
However,
development
pasteurized
forms
synthetic
mediums
offers
new
avenues
use
clinical
settings,
as
recognized
by
regulatory
bodies
like
European
Food
Safety
Authority.
narrative
serves
crucial
resource
understanding
broad
implications
different
conditions
integration
into
strategies.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 562 - 562
Опубликована: Янв. 31, 2025
Akkermansia
muciniphila
is
a
bacterium
commonly
found
in
the
human
gastrointestinal
tract
that
has
received
considerable
interest
as
potential
probiotic
for
improvement
of
gut
health
and
overall
metabolic
function.
A.
enriched
mucus
layer
intestinal
lining,
where
it
degrades
mucin
plays
significant
role
barrier
maintenance
immune
regulation.
A
higher
abundance
been
observed
healthy
individuals
relative
to
those
with
disorders,
multiple
benefits,
including
improved
glucose
management,
reduced
body
fat,
inflammation
have
linked
muciniphila.
Current
research
on
primarily
relies
mouse
models,
limited
interventional
studies
available.
While
these
animal
offer
valuable
insights
into
roles
disease,
further
clinical
investigations
humans
are
needed
fully
understand
its
impact.
Here,
we
explore
current
scope
therapeutic
agent
improve
while
also
emphasizing
need
optimize
techniques
this
organism.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 26, 2025
Development
and
severity
of
alcohol
use
disorder
(AUD)
has
been
linked
to
variations
in
gut
microbiota
their
associated
metabolites
both
animal
human
studies.
However,
the
involvement
microbiome
consumption
individuals
with
AUD
undergoing
treatment
remains
unclear.
To
address
this,
stool
samples
(n
=
32)
were
collected
at
screening
(baseline)
trial
completion
from
a
double-blind,
placebo-controlled
zonisamide
AUD.
Alcohol
was
measured
baseline
endpoint
16-week
period.
Fecal
analyzed
via
16
S
rRNA
sequencing
metabolome
untargeted
LC-MS.
Both
sex
(p
0.003)
psychotropic
medication
usage
0.025)
are
composition.
The
relative
abundance
11
genera
correlated
percent
drinking
reduction
(p.adj
<
0.1).
Overall
community
structure
differed
between
high
low
reducers
(67–100%
0–33%
reduction,
respectively;
p
0.034).
A
positive
relationship
fecal
GABA
levels
(R
0.43,
p.adj
0.07)
identified
by
function
prediction
confirmed
ELISA
metabolomics.
Metabolomics
analysis
also
found
3-hydroxykynurenine,
neurotoxic
intermediate
metabolite
tryptophan,
negatively
0.047),
over-represented
reducers.
These
findings
highlight
importance
amino
acid
participants
treatment.
It
may
hold
significant
value
as
predictive
tool
clinical
settings
better
personalize
intervention
improve
future.
Neurobiology of Disease,
Год журнала:
2025,
Номер
unknown, С. 106836 - 106836
Опубликована: Фев. 1, 2025
Ischemic
stroke
(IS)
is
a
cerebrovascular
disease
that
predominantly
affects
middle-aged
and
elderly
populations,
exhibiting
high
mortality
disability
rates.
At
present,
the
incidence
of
IS
increasing
annually,
with
notable
trend
towards
younger
affected
individuals.
Recent
discoveries
concerning
"gut-brain
axis"
have
established
connection
between
gut
brain.
Numerous
studies
revealed
intestinal
microbes
play
crucial
role
in
onset,
progression,
outcomes
IS.
They
are
involved
entire
pathophysiological
process
through
mechanisms
such
as
chronic
inflammation,
neural
regulation,
metabolic
processes.
Although
numerous
explored
relationship
microbiota,
comprehensive
analyses
specific
microbiota
relatively
scarce.
Therefore,
this
paper
provides
an
overview
typical
changes
following
investigates
microorganisms
context.
Additionally,
it
presents
analysis
post-stroke
microbiological
therapy
diet.
The
aim
to
identify
potential
microbial
targets
for
therapeutic
intervention,
well
highlight
benefits
therapies
significance
dietary
management.
Overall,
seeks
provide
key
strategies
treatment
management
IS,
advocating
healthy
diets
health
programs
Meanwhile,
may
offer
new
perspective
on
future
interdisciplinary
development
neurology,
microbiology
nutrition.
npj Parkinson s Disease,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 19, 2025
Abstract
Epidemiological
studies
reveal
that
inflammatory
bowel
disease
(IBD)
is
associated
with
an
increased
risk
of
Parkinson’s
(PD).
Gut
dysbiosis
has
been
documented
in
both
PD
and
IBD,
however
it
currently
unknown
whether
gut
underlies
the
epidemiological
association
between
diseases.
To
identify
shared
distinct
features
IBD
microbiome,
we
recruited
54
PD,
26
16
healthy
control
individuals
performed
first
joint
analysis
metagenomes.
Larger,
publicly
available
metagenomic
datasets
were
also
analyzed
to
validate
extend
our
findings.
Depletions
short-chain
fatty
acid
(SCFA)-producing
bacteria,
including
Roseburia
intestinalis,
Faecalibacterium
prausnitzii,
Anaerostipes
hadrus
,
Eubacterium
rectale
as
well
depletion
SCFA-synthesis
pathways
detected
across
datasets,
suggesting
these
microbes
may
influence
for
development.