Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Янв. 26, 2024

Patients diagnosed with inflammatory bowel disease (IBD) exhibit a notable prevalence of psychiatric disorders, such as anxiety and depression. Nevertheless, the etiology disorders associated IBD remains uncertain, an efficacious treatment approach has yet to be established. Herein, oral hydrogel strategy (SP@Rh-gel) is proposed for co-delivery Spirulina platensis rhein treat IBD-associated depression by modulating microbiota-gut-brain axis. SP@Rh-gel improves solubility, release characteristics intestinal retention capacity drug, leading significant improvement in therapeutic efficacy. Oral administration can reduce inflammation rebalance disrupted microbial community. Furthermore, maintains barrier integrity reduces pro-inflammatory factors their entry into hippocampus through blood-brain barrier, thereby inhibiting neuroinflammation maintaining neuroplasticity. significantly alleviates colitis symptoms, well anxiety- depression-like behaviors, chronic mouse model. This study demonstrates involvement axis development proposes safe, simple, highly efficient managing comorbid disorders.

Язык: Английский

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The Role of Diet and Gut Microbiota in Alzheimer’s Disease

Nutrients, Год журнала: 2024, Номер 16(3), С. 412 - 412

Опубликована: Янв. 31, 2024

Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by accumulation amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, (AD) impacts 50 million individuals, with projections anticipating an increase to 152 year 2050. Despite increasing global prevalence AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis treatment. Recent research suggests a link between gut dysbiosis aggregation Aβ, development proteins, occurrence neuroinflammation oxidative stress are associated AD. However, investigations into gut–brain axis (GBA) in context AD progression have yielded inconsistent findings. This review aims enhance our understanding microbial diversity at species level role these pathology. Additionally, this addresses influence confounding elements, including diet, probiotics, prebiotics, on throughout different stages (preclinical, mild cognitive impairment (MCI), AD) progression.

Язык: Английский

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Gut Microbiota Composition in Patients with Neurodegenerative Disorders (Parkinson’s and Alzheimer’s) and Healthy Controls: A Systematic Review

Nutrients, Год журнала: 2023, Номер 15(20), С. 4365 - 4365

Опубликована: Окт. 13, 2023

This systematic review aims to provide a comprehensive understanding of the current literature regarding gut microbiota composition in patients with Parkinson’s disease (PD) and Alzheimer’s (AD) compared healthy controls. To identify relevant studies, thorough search PubMed, Medline, Embase was conducted following PRISMA guidelines. Out 5627 articles, 73 studies were assessed for full-text eligibility, which led inclusion 42 (26 PD 16 AD studies). The risk bias assessment showed medium 32 (20 12 studies), low 9 (5 4 1 study high risk. Among 22 out 26 reported different between cases controls, 15 differences consistently identified phyla Bacteroidetes, Firmicutes, Proteobacteria as prevalent both groups case groups. Microbial dysbiosis specifically characterized by abundance Akkermansia, Verrucomicrobiaceae, Lachnospiraceae, Ruminococcaceae Blautia, Coprococcus, Prevotellaceae, Roseburia Similarly, Bacteroides Acidobacteriota abundant cases, Acidaminococcaceae, Ruminiclostridium microbial signature association several taxa, including Bifidobacterium, Ruminococcacea, Verrucomicrobia Ruminococcaceae, Bacteroides, Actinobacteria AD. diversity evaluations indicated comparable alpha some distinct others, consistent beta controls across multiple studies. bacterial signatures this that are associated may offer promising prospects efficient management treatment approaches.

Язык: Английский

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The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Nutrients, Год журнала: 2024, Номер 16(2), С. 308 - 308

Опубликована: Янв. 19, 2024

Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, it not without reason many enrich with diet in its name. Numerous connections mutual correlations have become basis for seeking answers questions pathology as well human physiology. Disorders this homeostasis dysbiosis itself accompany neurodegenerative diseases such Alzheimer's Parkinson's. Heavily dependent on external factors, modulation gut microbiome represents opportunity advance treatment Probiotic interventions, synbiotic or fecal transplantation can undoubtedly support biotherapeutic process. A special role played by diet, which provides metabolites directly affect body microbiota. holistic view organism therefore essential.

Язык: Английский

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 20: Suitability of taxonomic units notified to EFSA until March 2024

EFSA Journal, Год журнала: 2024, Номер 22(7)

Опубликована: Июль 1, 2024

Abstract The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. In the period covered by this statement, no new information found that would change status previously recommended QPS TUs. TUs list were updated based on verification, against their respective authoritative databases, correctness names and completeness synonyms. A procedure has been established ensure are kept up date relation recent taxonomical insights. Of 83 notified EFSA between October 2023 March 2024 (47 as additives, 25 enzymes 11 novel foods), 75 not evaluated because: 15 filamentous fungi, 1 Enterococcus faecium, 10 Escherichia coli, Streptomyces (all excluded from evaluation) 48 already have status. Two other eight notifications possible previous Panel Statement: Heyndrickxia faecalis (previously Weizmannia faecalis) Serratia marcescens. One at genus level so could be assessed five belonging Akkermansia muciniphila Actinomadura roseirufa still due concerns. Rhizobium radiobacter can with qualification production purposes. Microbacterium arborescens Burkholderia stagnalis cannot included lack body knowledge its chain B. also A. further assessment.

Язык: Английский

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Insights into the Mechanisms of Action of Akkermansia muciniphila in the Treatment of Non-Communicable Diseases

Nutrients, Год журнала: 2024, Номер 16(11), С. 1695 - 1695

Опубликована: Май 29, 2024

This comprehensive review delineates the extensive roles of Akkermansia muciniphila in various health domains, spanning from metabolic and inflammatory diseases to neurodegenerative disorders. A. muciniphila, known for its ability reside mucous layer intestine, plays a pivotal role maintaining gut integrity interacting with host processes. Its influence extends modulating immune responses potentially easing symptoms across several non-communicable diseases, including obesity, diabetes, bowel disease, cancer. Recent studies highlight capacity interact gut–brain axis, suggesting possible impact on neuropsychiatric conditions. Despite promising therapeutic potential highlighted animal preliminary human studies, challenges remain practical application due stability cultivation issues. However, development pasteurized forms synthetic mediums offers new avenues use clinical settings, as recognized by regulatory bodies like European Food Safety Authority. narrative serves crucial resource understanding broad implications different conditions integration into strategies.

Язык: Английский

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Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila

Nutrients, Год журнала: 2025, Номер 17(3), С. 562 - 562

Опубликована: Янв. 31, 2025

Akkermansia muciniphila is a bacterium commonly found in the human gastrointestinal tract that has received considerable interest as potential probiotic for improvement of gut health and overall metabolic function. A. enriched mucus layer intestinal lining, where it degrades mucin plays significant role barrier maintenance immune regulation. A higher abundance been observed healthy individuals relative to those with disorders, multiple benefits, including improved glucose management, reduced body fat, inflammation have linked muciniphila. Current research on primarily relies mouse models, limited interventional studies available. While these animal offer valuable insights into roles disease, further clinical investigations humans are needed fully understand its impact. Here, we explore current scope therapeutic agent improve while also emphasizing need optimize techniques this organism.

Язык: Английский

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Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 26, 2025

Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota their associated metabolites both animal human studies. However, the involvement microbiome consumption individuals with AUD undergoing treatment remains unclear. To address this, stool samples (n = 32) were collected at screening (baseline) trial completion from a double-blind, placebo-controlled zonisamide AUD. Alcohol was measured baseline endpoint 16-week period. Fecal analyzed via 16 S rRNA sequencing metabolome untargeted LC-MS. Both sex (p 0.003) psychotropic medication usage 0.025) are composition. The relative abundance 11 genera correlated percent drinking reduction (p.adj < 0.1). Overall community structure differed between high low reducers (67–100% 0–33% reduction, respectively; p 0.034). A positive relationship fecal GABA levels (R 0.43, p.adj 0.07) identified by function prediction confirmed ELISA metabolomics. Metabolomics analysis also found 3-hydroxykynurenine, neurotoxic intermediate metabolite tryptophan, negatively 0.047), over-represented reducers. These findings highlight importance amino acid participants treatment. It may hold significant value as predictive tool clinical settings better personalize intervention improve future.

Язык: Английский

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The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke

Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106836 - 106836

Опубликована: Фев. 1, 2025

Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality disability rates. At present, the incidence of IS increasing annually, with notable trend towards younger affected individuals. Recent discoveries concerning "gut-brain axis" have established connection between gut brain. Numerous studies revealed intestinal microbes play crucial role in onset, progression, outcomes IS. They are involved entire pathophysiological process through mechanisms such as chronic inflammation, neural regulation, metabolic processes. Although numerous explored relationship microbiota, comprehensive analyses specific microbiota relatively scarce. Therefore, this paper provides an overview typical changes following investigates microorganisms context. Additionally, it presents analysis post-stroke microbiological therapy diet. The aim to identify potential microbial targets for therapeutic intervention, well highlight benefits therapies significance dietary management. Overall, seeks provide key strategies treatment management IS, advocating healthy diets health programs Meanwhile, may offer new perspective on future interdisciplinary development neurology, microbiology nutrition.

Язык: Английский

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Comparative analysis of Parkinson’s and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Март 19, 2025

Abstract Epidemiological studies reveal that inflammatory bowel disease (IBD) is associated with an increased risk of Parkinson’s (PD). Gut dysbiosis has been documented in both PD and IBD, however it currently unknown whether gut underlies the epidemiological association between diseases. To identify shared distinct features IBD microbiome, we recruited 54 PD, 26 16 healthy control individuals performed first joint analysis metagenomes. Larger, publicly available metagenomic datasets were also analyzed to validate extend our findings. Depletions short-chain fatty acid (SCFA)-producing bacteria, including Roseburia intestinalis, Faecalibacterium prausnitzii, Anaerostipes hadrus , Eubacterium rectale as well depletion SCFA-synthesis pathways detected across datasets, suggesting these microbes may influence for development.

Язык: Английский

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