Abstract
Excessive
accumulation
of
reactive
oxygen
species
(ROS)
and
dysbiosis
gut
microbiota
are
pivotal
etiological
factors
in
the
pathogenesis
ulcerative
colitis
(UC)
its
associated
intestinal
extraintestinal
manifestations
(e.g.,
microthrombosis,
anxiety,
depression
symptoms).
This
investigation
presents
a
multifunctional
inulin
complex
(PB/NKase@Inulin
gel)
incorporating
Prussian
blue
nanozymes
(PB
NZs)
thrombolytic
agent
nattokinase
(NKase)
for
therapeutic
management
dextran
sulfate
sodium
(DSS)‐induced
UC
complications.
Following
oral
administration,
PB/NKase@Inulin
gel,
characterized
by
prolonged
retention
PB
NZs
NKase
at
inflamed
colonic
sites,
can
facilitate
continuously
ROS
scavenging,
attenuate
oxidative
stress
damage,
effectively
reduce
pro‐inflammatory
cytokine
levels.
Importantly,
gel
not
only
robustly
inhibit
inflammatory
microthrombosis
formation
but
also
lyses
thrombi
due
to
potent
properties
both
vitro
vivo.
Furthermore,
is
able
modulate
homeostasis
alleviate
multiple
stresses
responses
(including
anxiety
depression)
mouse
model
via
microbiota‐gut‐brain
(MGB)
axis
interactions.
Overall,
offers
an
innovative
paradigm
comprehensive
interventions
DSS‐induced
multifaceted
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 21, 2024
Novel
biomaterials
are
becoming
more
crucial
in
treating
human
diseases.
However,
many
materials
require
complex
artificial
modifications
and
synthesis,
leading
to
potential
difficulties
preparation,
side
effects,
clinical
translation.
Recently,
significant
progress
has
been
achieved
terms
of
direct
self-assembly
natural
products
from
herbal
medicine
(NPHM),
an
important
source
for
novel
medications,
resulting
a
wide
range
bioactive
supramolecular
including
gels,
nanoparticles.
The
NPHM-based
produced
renewable
resources,
simple
prepare,
have
demonstrated
multi-functionality
slow-release,
smart-responsive
release,
especially
possess
powerful
biological
effects
treat
various
In
this
review,
revealed
as
emerging,
revolutionary,
promising
strategy.
development,
advantages,
limitations
NPHM,
well
the
advantageous
position
materials,
first
reviewed.
Subsequently,
systematic
comprehensive
analysis
strategies
specific
seven
major
classes
NPHM
is
highlighted.
Insights
into
influence
structural
features
on
formation
also
provided.
Finally,
drivers
preparations
summarized,
emphasizing
biomedical
applications,
future
scientific
challenges,
opportunities,
with
hope
igniting
inspiration
research
applications.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Natural
plant‐derived
polysaccharides
exhibit
substantial
potential
for
treating
ulcerative
colitis
(UC)
owing
to
their
anti‐inflammatory
and
antioxidant
properties
favorable
safety
profiles.
However,
practical
application
faces
several
challenges,
including
structural
instability
in
gastric
acid,
imprecise
targeting
of
inflamed
regions,
limited
intestinal
retention
times.
To
address
these
limitations,
pH‐responsive,
colon‐targeting
microspheres
(pWGPAC
MSs)
are
developed
delivering
phosphorylated
wild
ginseng
(pWGP)
alleviate
UC.
These
pWGPAC
MSs
fabricated
by
incorporating
pWGP
into
calcium‐crosslinked
alginate
with
subsequent
chitosan
surface
modification
enhance
mucosal
adhesion.
demonstrated
exceptional
stability
under
acidic
conditions
while
enabling
targeted
release
the
colon.
In
a
mouse
model
UC,
effectively
mitigated
injury,
attenuated
inflammation,
restored
barrier
function.
Further
mechanistic
investigations
revealed
that
modulated
TLR4/MYD88
signaling
pathway
promoted
M2
macrophage
polarization.
Integrated
microbiome
metabolome
analyses
regulated
gut
microbiota
composition
decreased
pro‐inflammatory
metabolite
levels.
addition,
promising
Collectively,
findings
establish
as
therapeutic
strategy
treatment
UC
provide
solid
foundation
future
clinical
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Май 7, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
encompasses
a
collection
of
chronic
inflammatory
conditions
impacting
the
gastrointestinal
tract,
with
discernible
global
rise
in
prevalence
and
severity.
The
overabundance
reactive
oxygen
species
(ROS)
intestinal
environment
leads
disruption
local
redox
homeostasis,
perturbation
gut
microbiota,
exacerbating
IBD.
Consequently,
mitigating
excess
ROS
preserving
microbiota
homeostasis
have
emerged
as
effective
approaches
for
IBD
management.
In
this
study,
triangular
DNA
origami
nanostructure
loaded
siRNA
targeting
tumor
necrosis
factor
α
(
siTNF‐α
tDON)
is
introduced
purpose.
This
demonstrates
efficacy
eliminating
within
cells
closely
associated
IBD,
diminishing
inflammation,
ameliorating
disorders
evidenced
an
mouse
model.
Furthermore,
investigation
effects
tDON
on
related
signaling
pathways,
including
NF‐κB,
MAPK/ERK
Keap1/Nrf2.
Collectively,
study
offers
insights
into
potential
utilization
nanostructures
antioxidants
modulators,
presenting
promising
avenues
treatment.
Treatment
of
osteoarthritis
(OA)
remains
challenging
owing
to
its
complex
pathological
microenvironment,
which
involves
reactive
oxygen
species,
chronic
inflammation,
mitochondrial
dysfunction,
energy
deficiency,
and
cartilage
degeneration.
Herein,
we
report
for
extracellular
vesicles
(SP-EVs)
derived
from
the
photosynthetic
microorganism
Spirulina
platensis
contain
antioxidative
ATP-dependent
active
metabolic-related
compounds
OA
treatment.
SP-EVs
were
effectively
delivered
chondrocytes,
demonstrating
potential
modulating
cellular
communication
homeostasis.
To
facilitate
sustained
delivery
SP-EVs,
rhein
hydrogel
system
was
used
intra-articular
injection
(Rh
Gel@SP-EVs),
demonstrated
pH
responsiveness
under
mildly
acidic
conditions
synergistic
anti-inflammatory
effects.
Rh
Gel@SP-EVs
significantly
rescued
dysfunction
by
ameliorating
inflammation-mediated
oxidative
stress
restoring
membrane
in
chondrocytes.
Improved
function
facilitates
replenishment
ATP
levels,
further
contributing
balance
anabolic
catabolic
processes
within
matrix,
eventually
decelerating
progression.
also
modulated
Janus
kinase-signal
transducer
activator
transcription
3
signaling
pathway,
implicated
suppressing
inflammatory
responses.
This
therapeutic
strategy
utilized
a
microalgae-based
herbal
modulate
release
offering
an
effective
approach
treating
regulating
metabolism
mechanisms.
