Green Synthesis of Zinc Oxide Nanoparticles from Althaea officinalis Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 3045 - 3070

Опубликована: Март 1, 2024

Background: Diabetes Mellitus is a multisystem chronic pandemic, wound inflammation, and healing are still major issues for diabetic patients who may suffer from ulcers, gangrene, other wounds uncontrolled hyperglycemia. Marshmallows or Althaea officinalis (A.O.) contain bioactive compounds such as flavonoids phenolics that support via antioxidant, anti-inflammatory, antibacterial properties. Our study aimed to develop combination of eco-friendly formulations green synthesis ZnO-NPs by extract further incorporate them into 2% chitosan (CS) gel. Method Results: First, Zinc Oxide Nanoparticles (ZnO-NPs) In-vitro performed UV-visible spectrum analysis showed sharp peak at 390 nm, Energy-dispersive X-ray (EDX) spectrometry zinc oxygen. Besides, Fourier transforms infrared (FTIR) was used qualitatively validate biosynthesized ZnO-NPs, transmission electron microscope (TEM) spherical nanoparticles with mean sizes 76 nm Zeta potential +30mV. The A.O.-ZnO-NPs-Cs examined the diffusion agar method against Gram-positive ( Staphylococcus aureus Bacillus subtilis ) Gram-negative bacteria Escherichia coli Pseudomonas aeruginosa ). Based on zone inhibition minimal inhibitory indices (MIC). In addition, an in-silico investigated binding affinity A.O . components expected biological targets aid healing. Officinalis , A.O-ZnO-NPs group reduced downregulation IL-6, IL-1β, TNF-α increased IL-10 levels compared control signaling pathway expression confirming improved anti-inflammatory effect self-assembly method. In-vivo histopathological revealed superiority in reducing signs inflammation incision rat models. Conclusion: These biocompatible oxide nanoparticles, using gel ensure excellent new therapeutic approach quickening Keywords: healing, antimicrobial, chitosan, concentration,

Язык: Английский

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Sustainable green synthesis of silver nanoparticles for safer biomedical application

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 115998 - 115998

Опубликована: Фев. 1, 2025

Язык: Английский

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Transport of nanoparticles in porous media and associated environmental impact: A review.

Journal of Engineering Research, Год журнала: 2024, Номер 12(2), С. 275 - 284

Опубликована: Янв. 9, 2024

The release of nanoparticles into the environment occurs at different stages during their life cycle, with significant harmful effects on human (e.g., lung inflammation and heart problems) ecosystem soil groundwater contamination). While colloids (particles >1 micrometre) behaviour in porous media is influenced by filtration, (<100 nanometres) driven Brownian motion quantum effects. Recognising these disparities essential for applications like remediation drug delivery, enabling precise strategies based differing transport dynamics nanoparticles. extent impact nanoparticle strongly type, size, concentration, interaction media. main factor preventing use environmental other related processes toxicity arising from uncontrolled distribution beyond application points. Finding a suitable dosing strategy applying media, necessary correct placement deposition target zones, one challenges researchers engineers face advancing subsurface application. Thus, further studies are to create model-based prevent dispersion In general, this review explores concerning its remediation. aim study captured under following: Identifying properties develop an innovative approach reclaim contaminated aquifers effectively. Identify critical parameters modelling effective nanoparticle-controlled This would require general understanding onset mapping depositional mechanisms existing or closely using controlling particulate focusing shortcomings.

Язык: Английский

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Biogenic synthesis of silver nanoparticles from leaves extract of Decaschistia trilobata an endemic shrub and its application as antioxidant, antibacterial, anti-inflammatory and dye reduction

Catalysis Communications, Год журнала: 2024, Номер 187, С. 106865 - 106865

Опубликована: Фев. 1, 2024

The present work reports for the first time use of Decaschistia trilobata Wight. as a reducing agent synthesis silver nanoparticles (AgNPs). D. is an endemic shrub and grows seasonally in dry tropical biome, evergreen forests hilly terrain western ghats. One most fascinating metallic utilized biological applications AgNPs. In green stable using (Dt-AgNPs) leaves extract well quantitative analysis phytochemicals. synthesized Dt-AgNPs were characterized evaluated their antioxidant anti-inflammatory, antibacterial dye reduction.

Язык: Английский

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Sustainable green synthesis of high-performance Fe2O3@CeO2-pullulan nanocomposite for efficient dye removal, and antifungal applications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142533 - 142533

Опубликована: Март 1, 2025

Язык: Английский

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Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Future Science OA, Год журнала: 2024, Номер 10(1)

Опубликована: Март 11, 2024

In green biological synthesis, metal nanoparticles are produced by plants or microorganisms. Since it is ecologically friendly, economically viable and sustainable, this method preferable to other traditional ones. For their continuous groundbreaking advancements myriad physiochemical benefits, nanotechnologies have influenced various aspects of scientific fields. Metal (MNPs) the field anchor for outstanding optical, electrical chemical capabilities that outperform regular-sized counterparts. This review discusses most current biosynthesized synthesized organisms applications along with key elements involved in MNP synthesis. The displayed a manner will impart assertiveness, help researchers open questions, highlight many points conducting future research.

Язык: Английский

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Advancements in 2D nanomaterial-enhanced nanofluids: Stability, thermophysical properties, and industrial applications

Powder Technology, Год журнала: 2025, Номер 454, С. 120687 - 120687

Опубликована: Янв. 23, 2025

Язык: Английский

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Green synthesis of zinc oxide nanoparticles using Cnidium monnieri fruit extract: Prescription optimization, Characterization and antifungal activity

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107256 - 107256

Опубликована: Фев. 1, 2025

Язык: Английский

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Eco-Friendly Production of Antimicrobial Nanoparticles for Sustainability

Опубликована: Янв. 1, 2025

Язык: Английский

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Augmented Marshmallow Extract Lipid Nanoparticles with Clove Oil Embedded in Collagen Sponge for Ultimate Antimicrobial Healing of Diabetic Mouth Ulcer

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 611 - 611

Опубликована: Май 5, 2025

Background/Objectives: Diabetic mouth ulcers are a pathological condition of the oral mucosa leading to increases in susceptibility infection and prolonged wound healing time. Still, there is lack natural formulations for treating this condition. Our principal objective was formulate solid lipid nanoparticles (SLNs) that contained Althaea officinalis (marshmallow) (M.) extract with clove oil (CO.), subsequently integrated into collagen sponge enhancing stability, solubility, sustained release, antimicrobial efficacy, power when targeting diabetic ulcers. Methods: A factorial design 34 trials established evaluate influence concentration (A), SAA (B), type (C), (D). The optimized M-CO-SLNs selected using Design Expert®, based Poly dispersibility index (Y2), zeta potential (MV) (Y3), encapsulation efficiency (%) (Y4). SLNs were matrix tested their antibacterial antifungal efficacy against Pseudomonas aeruginosa, Escherichia coli, Candida albicans, respectively. Moreover, they ulcer model. Results: formula (Run 16: 5% concentration, 4% capric acid) demonstrated P.S (110 ± 0.76 nm), ZP (-24 0.32 mV), PDI (0.18 0.05), EE% (90 0.65%.). incorporated cross-linked showed superior an increased swelling ratio, effective vivo study, as evidenced by ELISA biomarkers, gene expression analysis, histological analysis. Conclusions: embedded sponges promising therapeutic clinical application

Язык: Английский

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