International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3045 - 3070
Published: March 1, 2024
Background:
Diabetes
Mellitus
is
a
multisystem
chronic
pandemic,
wound
inflammation,
and
healing
are
still
major
issues
for
diabetic
patients
who
may
suffer
from
ulcers,
gangrene,
other
wounds
uncontrolled
hyperglycemia.
Marshmallows
or
Althaea
officinalis
(A.O.)
contain
bioactive
compounds
such
as
flavonoids
phenolics
that
support
via
antioxidant,
anti-inflammatory,
antibacterial
properties.
Our
study
aimed
to
develop
combination
of
eco-friendly
formulations
green
synthesis
ZnO-NPs
by
extract
further
incorporate
them
into
2%
chitosan
(CS)
gel.
Method
Results:
First,
Zinc
Oxide
Nanoparticles
(ZnO-NPs)
In-vitro
performed
UV-visible
spectrum
analysis
showed
sharp
peak
at
390
nm,
Energy-dispersive
X-ray
(EDX)
spectrometry
zinc
oxygen.
Besides,
Fourier
transforms
infrared
(FTIR)
was
used
qualitatively
validate
biosynthesized
ZnO-NPs,
transmission
electron
microscope
(TEM)
spherical
nanoparticles
with
mean
sizes
76
nm
Zeta
potential
+30mV.
The
A.O.-ZnO-NPs-Cs
examined
the
diffusion
agar
method
against
Gram-positive
(
Staphylococcus
aureus
Bacillus
subtilis
)
Gram-negative
bacteria
Escherichia
coli
Pseudomonas
aeruginosa
).
Based
on
zone
inhibition
minimal
inhibitory
indices
(MIC).
In
addition,
an
in-silico
investigated
binding
affinity
A.O
.
components
expected
biological
targets
aid
healing.
Officinalis
,
A.O-ZnO-NPs
group
reduced
downregulation
IL-6,
IL-1β,
TNF-α
increased
IL-10
levels
compared
control
signaling
pathway
expression
confirming
improved
anti-inflammatory
effect
self-assembly
method.
In-vivo
histopathological
revealed
superiority
in
reducing
signs
inflammation
incision
rat
models.
Conclusion:
These
biocompatible
oxide
nanoparticles,
using
gel
ensure
excellent
new
therapeutic
approach
quickening
Keywords:
healing,
antimicrobial,
chitosan,
concentration,
Journal of Engineering Research,
Journal Year:
2024,
Volume and Issue:
12(2), P. 275 - 284
Published: Jan. 9, 2024
The
release
of
nanoparticles
into
the
environment
occurs
at
different
stages
during
their
life
cycle,
with
significant
harmful
effects
on
human
(e.g.,
lung
inflammation
and
heart
problems)
ecosystem
soil
groundwater
contamination).
While
colloids
(particles
>1
micrometre)
behaviour
in
porous
media
is
influenced
by
filtration,
(<100
nanometres)
driven
Brownian
motion
quantum
effects.
Recognising
these
disparities
essential
for
applications
like
remediation
drug
delivery,
enabling
precise
strategies
based
differing
transport
dynamics
nanoparticles.
extent
impact
nanoparticle
strongly
type,
size,
concentration,
interaction
media.
main
factor
preventing
use
environmental
other
related
processes
toxicity
arising
from
uncontrolled
distribution
beyond
application
points.
Finding
a
suitable
dosing
strategy
applying
media,
necessary
correct
placement
deposition
target
zones,
one
challenges
researchers
engineers
face
advancing
subsurface
application.
Thus,
further
studies
are
to
create
model-based
prevent
dispersion
In
general,
this
review
explores
concerning
its
remediation.
aim
study
captured
under
following:
Identifying
properties
develop
an
innovative
approach
reclaim
contaminated
aquifers
effectively.
Identify
critical
parameters
modelling
effective
nanoparticle-controlled
This
would
require
general
understanding
onset
mapping
depositional
mechanisms
existing
or
closely
using
controlling
particulate
focusing
shortcomings.
Catalysis Communications,
Journal Year:
2024,
Volume and Issue:
187, P. 106865 - 106865
Published: Feb. 1, 2024
The
present
work
reports
for
the
first
time
use
of
Decaschistia
trilobata
Wight.
as
a
reducing
agent
synthesis
silver
nanoparticles
(AgNPs).
D.
is
an
endemic
shrub
and
grows
seasonally
in
dry
tropical
biome,
evergreen
forests
hilly
terrain
western
ghats.
One
most
fascinating
metallic
utilized
biological
applications
AgNPs.
In
green
stable
using
(Dt-AgNPs)
leaves
extract
well
quantitative
analysis
phytochemicals.
synthesized
Dt-AgNPs
were
characterized
evaluated
their
antioxidant
anti-inflammatory,
antibacterial
dye
reduction.
Future Science OA,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: March 11, 2024
In
green
biological
synthesis,
metal
nanoparticles
are
produced
by
plants
or
microorganisms.
Since
it
is
ecologically
friendly,
economically
viable
and
sustainable,
this
method
preferable
to
other
traditional
ones.
For
their
continuous
groundbreaking
advancements
myriad
physiochemical
benefits,
nanotechnologies
have
influenced
various
aspects
of
scientific
fields.
Metal
(MNPs)
the
field
anchor
for
outstanding
optical,
electrical
chemical
capabilities
that
outperform
regular-sized
counterparts.
This
review
discusses
most
current
biosynthesized
synthesized
organisms
applications
along
with
key
elements
involved
in
MNP
synthesis.
The
displayed
a
manner
will
impart
assertiveness,
help
researchers
open
questions,
highlight
many
points
conducting
future
research.
Brazilian Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
61
Published: Jan. 1, 2025
Abstract
Pathogenic
strains
of
Escherichia
coli
can
cause
gastrointestinal
infections,
urinary
tract
infections
(UTIs),
bacteremia,
and
other
severe
infections.
Some
isolates
this
species
are
capable
producing
extended-spectrum
β-lactamase
(ESBL)
enzymes,
which
mediate
resistance
against
penicillin
derivates
cephalosporins.
Fungi
the
Ascomycota
phylum
known
to
produce
antibiotics
from
different
classes
with
activity
various
bacterial
agents.
Among
them,
genera
Penicillium,
Cephalosporium,
Acremonium
Fusidium
for
production
antimicrobial
substances
such
as
derivates,
cephalosporins
fusidic
acid.
Currently,
search
new
antimicrobials
produced
by
includes
assessment
less
explored
habitats
including
aquatic
environments,
extreme
interior
plants/animals.
The
genus
Penicillium
remains
promising
discovery
resistant
bacteria.
In
addition,
those
fungi
have
also
been
investigated
regarding
their
usefulness
biosynthesis
nanoparticles
activity.
This
narrative
review
introduces
clinically
relevant
pathovars,
historical
contributions
antimicrobials,
aspects
bioprocesses
in
metabolites
approaches
research
targeting
screenings
environments
not
yet
studied
green
synthesis
mediated
