POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/β-catenin and NF-κB signal pathway in intervertebral disc degeneration
Cellular Signalling,
Год журнала:
2024,
Номер
121, С. 111277 - 111277
Опубликована: Июнь 28, 2024
Язык: Английский
Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 979 - 979
Опубликована: Июль 24, 2024
Intervertebral
disc
degeneration
(IVDD)
stands
as
the
foremost
contributor
to
low
back
pain
(LBP),
imposing
a
substantial
weight
on
world
economy.
Traditional
treatment
modalities
encompass
both
conservative
approaches
and
surgical
interventions;
however,
former
falls
short
in
halting
IVDD
progression,
while
latter
carries
inherent
risks.
Hence,
quest
for
an
efficacious
method
reverse
onset
is
paramount.
Biomaterial
delivery
systems,
exemplified
by
hydrogels,
microspheres,
microneedles,
renowned
their
exceptional
biocompatibility,
biodegradability,
biological
efficacy,
mechanical
attributes,
have
found
widespread
application
bone,
cartilage,
various
tissue
engineering
endeavors.
Consequently,
IVD
has
emerged
burgeoning
field
of
interest.
This
paper
succinctly
introduces
intervertebral
(IVD)
structure
pathophysiology
IVDD,
meticulously
classifies
biomaterials
repair,
reviews
recent
advances
field.
Particularly,
strengths
weaknesses
are
emphasized,
potential
avenues
future
research
suggested.
Язык: Английский
Polysaccharide-Based Biomaterials for Regenerative Therapy in Intervertebral Disc Degeneration
Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101395 - 101395
Опубликована: Дек. 10, 2024
Язык: Английский
Investigating the characteristics of mild intervertebral disc degeneration at various age stages using single-cell genomics
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Июль 2, 2024
Introduction:
Intervertebral
disc
degeneration
often
occurs
in
the
elderly
population,
but
recent
years,
there
has
been
an
increasing
incidence
of
younger
individuals,
primarily
with
mild
degeneration.
Methods:
In
order
to
explore
underlying
mechanisms
both
young
and
aging
we
collected
four
types
nucleus
pulposus
(NP)
single-cell
sequencing
samples
for
analysis
based
on
Pfirrmann
grading:
normal-young
(NY)
(Grade
I),
normal-old
(NO)
degenerative-young
(MY)
II-III),
degenerative-old
(MO)
II-III).
Results:
We
found
that
most
NP
cells
NO
MY
exhibited
oxidative
stress,
which
may
be
important
pathogenic
factors
groups.
On
other
hand,
MO
group
endoplasmic
reticulum
stress.
terms
inflammation,
myeloid
were
mainly
present
degenerative
group,
showing
a
stronger
immune
response
compared
group.
Interestingly,
dendritic
lineage
played
critical
role
process
Discussion:
Our
study
investigated
molecular
intervertebral
from
age
perspective,
providing
insights
improving
treatment
strategies
patients
at
different
Язык: Английский