Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Outer
membrane
vesicles
(OMVs)
and
exosomes
are
essential
mediators
of
host-pathogen
interactions.
Elucidating
their
mechanisms
action
offers
valuable
insights
into
diagnosing
treating
infectious
diseases
cancers.
However,
the
specific
interactions
Helicobacter
pylori
(
H.
)
with
host
cells
via
OMVs
in
modulating
immune
responses
have
not
been
thoroughly
investigated.
This
review
explores
how
these
elicit
inflammatory
immunosuppressive
environment,
facilitate
pathogen
invasion
cells,
enable
evasion
defenses,
thereby
contributing
to
progression
gastric
extra-gastric
disseminated
through
bloodstream.
Furthermore,
discusses
challenges
future
directions
for
investigating
exosomes,
underscoring
potential
as
therapeutic
targets
-associated
diseases.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 28, 2024
,
a
globally
prevalent
pathogen
Group
I
carcinogen,
presents
formidable
challenge
in
gastric
cancer
prevention
due
to
its
increasing
antimicrobial
resistance
and
strain
diversity.
This
comprehensive
review
critically
analyzes
the
limitations
of
conventional
antibiotic-based
therapies
explores
cutting-edge
approaches
combat
Food & Function,
Год журнала:
2024,
Номер
15(16), С. 8418 - 8431
Опубликована: Янв. 1, 2024
H.
pylori
is
a
highly
pathogenic
and
prevalent
pathogen
that
class
I
carcinogen.
More
than
50%
of
the
world's
population
infected
with
pylori.
An
anti-adhesive
strategy
an
effective
way
to
antagonize
infection,
which
does
not
cause
resistance
safer
compared
antibiotic
therapy.
In
present
study,
obtain
rice
bran
protein-derived
activity
peptides
against
pylori,
efficient
enzymatic
hydrolysis
system
was
established,
it
found
protein
hydrolysate
prepared
under
specific
conditions
possessed
The
(RPH)
43.74
±
1.12%
(4
mg
mL-1),
gastric
digestion
(RPHA)
had
no
significant
effect
on
its
activity.
Hydrophobic
amino
acids
aromatic
were
important
for
Further,
284
peptide
sequences
potential
isolated
identified
from
RPHA.
Combined
molecular
docking
results,
four
novel
finally
screened,
namely
LS5
(LSFRL),
SN8
(SNTPGMVY),
VV7
(VVNFGNL)
PV9
(PVLWGVPKG).
Among
them,
showed
highest
59.64
2.00%
mL-1).
These
could
bind
adhesins
BabA
SabA,
occupying
binding
sites
cell
receptors
acting
as
anti-adhesion
agents.
conclusion,
can
be
used
development
functional
foods
antagonizing
infection.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Outer
membrane
vesicles
(OMVs)
and
exosomes
are
essential
mediators
of
host-pathogen
interactions.
Elucidating
their
mechanisms
action
offers
valuable
insights
into
diagnosing
treating
infectious
diseases
cancers.
However,
the
specific
interactions
Helicobacter
pylori
(
H.
)
with
host
cells
via
OMVs
in
modulating
immune
responses
have
not
been
thoroughly
investigated.
This
review
explores
how
these
elicit
inflammatory
immunosuppressive
environment,
facilitate
pathogen
invasion
cells,
enable
evasion
defenses,
thereby
contributing
to
progression
gastric
extra-gastric
disseminated
through
bloodstream.
Furthermore,
discusses
challenges
future
directions
for
investigating
exosomes,
underscoring
potential
as
therapeutic
targets
-associated
diseases.
