Mycobacterium tuberculosis infection may increase the degrees of malignancy in lung adenocarcinoma
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 21, 2025
The
early
diagnosis
and
management
of
lung
adenocarcinoma
co-existing
with
tuberculosis
(LAC-TB)
presents
significant
challenges
in
clinical
settings.
This
is
compounded
by
a
paucity
robust
evidence
elucidating
the
interactions
between
these
two
conditions.
study
included
14
patients
diagnosed
LAC-TB,
an
equal
distribution
among
those
pulmonary
(TB)
peripheral
lymph
node
TB.
Controls
simple
TB
(LAC).
Histopathologic
examinations
confirmed
typical
changes
each
group.
Immunohistochemistry
analyzed
immune
markers,
focusing
on
PD-L1,
while
genomic
analysis
identified
differential
mutant
genes.
Pathological
evaluations
showed
that
LAC-TB
LAC
groups
expressed
TTF-1
Napsin
A
their
specimens.
Notably,
higher
proportion
group
had
Ki-67
proliferation
index
≥10%.
Subsequent
Molecular
analyses
revealed
differences
RALGAPA1
gene
expression,
also
exhibiting
greater
median
count
missense
mutations,
single
nucleotide
polymorphisms,
overall
suggesting
malignancy
level
than
Additionally,
increased
tumor
mutational
burden,
indicating
potentially
better
response
to
immunotherapy.
Immunohistochemical
assessments
indicated
Mycobacterium
(MTB)
infection
correlated
reduced
infiltration
T
cells
CD4+
cells,
alongside
upregulation
PD-L1
expression
LAC.
was
strongly
granuloma
surrounding
areas.
Our
findings
suggest
MTB
may
increase
LAC,
pronounced
regions
constituting
pivotal
mechanism
underlying
this
relationship.
Язык: Английский
Characterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 30, 2024
Hepatic
tuberculosis
(HTB)
is
rare
extrapulmonary
that
clinically
similar
to
liver
malignancy,
making
it
difficult
for
correct
diagnoses.
Pathology
the
gold
standard
diagnosis.
However,
there
are
few
reports
on
pathological
features
of
HTB.
A
total
32
HTB
cases
were
considered
and
differences
in
drug
resistance
analyzed
compared
with
those
pulmonary
(PTB).
Enhanced
CT
scans
showed
ring-shaped
delayed
enhancement
during
arterial,
venous,
phases.
Most
single
lesions,
highest
incidence
right
lobe,
average
lesion
volume
was
smaller
than
PTB.
The
frequency
granuloma
changes,
overall
share
area
group,
number
foxp3
+
cells
significantly
higher
PTB
group.
no
statistically
significant
observed
between
two
groups’
other
immune
cell
numbers.
microenvironment
normal
tissues
surrounding
further
analyzed.
findings
macrophages
group
No
difference
detected
groups.
In
conclusion,
substantial
characterization
feature
subsequent
Язык: Английский