Mycobacterium tuberculosis infection may increase the degrees of malignancy in lung adenocarcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

The early diagnosis and management of lung adenocarcinoma co-existing with tuberculosis (LAC-TB) presents significant challenges in clinical settings. This is compounded by a paucity robust evidence elucidating the interactions between these two conditions. study included 14 patients diagnosed LAC-TB, an equal distribution among those pulmonary (TB) peripheral lymph node TB. Controls simple TB (LAC). Histopathologic examinations confirmed typical changes each group. Immunohistochemistry analyzed immune markers, focusing on PD-L1, while genomic analysis identified differential mutant genes. Pathological evaluations showed that LAC-TB LAC groups expressed TTF-1 Napsin A their specimens. Notably, higher proportion group had Ki-67 proliferation index ≥10%. Subsequent Molecular analyses revealed differences RALGAPA1 gene expression, also exhibiting greater median count missense mutations, single nucleotide polymorphisms, overall suggesting malignancy level than Additionally, increased tumor mutational burden, indicating potentially better response to immunotherapy. Immunohistochemical assessments indicated Mycobacterium (MTB) infection correlated reduced infiltration T cells CD4+ cells, alongside upregulation PD-L1 expression LAC. was strongly granuloma surrounding areas. Our findings suggest MTB may increase LAC, pronounced regions constituting pivotal mechanism underlying this relationship.

Language: Английский

Characterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 30, 2024

Hepatic tuberculosis (HTB) is rare extrapulmonary that clinically similar to liver malignancy, making it difficult for correct diagnoses. Pathology the gold standard diagnosis. However, there are few reports on pathological features of HTB. A total 32 HTB cases were considered and differences in drug resistance analyzed compared with those pulmonary (PTB). Enhanced CT scans showed ring-shaped delayed enhancement during arterial, venous, phases. Most single lesions, highest incidence right lobe, average lesion volume was smaller than PTB. The frequency granuloma changes, overall share area group, number foxp3 + cells significantly higher PTB group. no statistically significant observed between two groups’ other immune cell numbers. microenvironment normal tissues surrounding further analyzed. findings macrophages group No difference detected groups. In conclusion, substantial characterization feature subsequent

Language: Английский