Precision medicine for personalized cholecystitis care: integrating molecular diagnostics and biotherapeutics

Bulletin of the National Research Centre/Bulletin of the National Research Center, Год журнала: 2024, Номер 48(1)

Опубликована: Сен. 12, 2024

Abstract Background Acute cholecystitis, inflammation of the gallbladder, can lead to serious complications if not promptly diagnosed and managed. Conventional therapies have limitations, necessitating newer personalized approaches. Main body abstract This review examines recent advances transforming cholecystitis care. Diagnostically, molecular techniques like next-generation sequencing rapidly identify causative microbes from gallbladder specimens, enabling targeted antimicrobial therapy. Regarding treatment, phage therapy uses viruses lyse pathogenic bacteria. RNA interference CRISPR-Cas9 gene editing silence microbial virulence factors. Probiotics competitively exclude pathogens. Robotics fluorescence imaging refine surgical techniques. Additional emerging modalities include biosensors detecting inflammatory mediators, regenerative tissue engineering using stem cells, artificial intelligence for real-time decision support. However, optimal integration novel technologies with current best practices remains unknown. Further research is needed validate optimize diagnostics therapeutics cholecystitis. Short conclusions Advances in sequencing, CRISPR editing, robotics, other biotechnologies promise transform precision management when thoughtfully implemented. controlled trials are still required define conventional supportive care antibiotics.

Язык: Английский

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Glucosinolates and Indole-3-carbinol from Brassica oleracea L. as inhibitors of E. coli CdtB: insights from molecular docking, dynamics, DFT and in vitro assay

In Silico Pharmacology, Год журнала: 2024, Номер 12(2)

Опубликована: Окт. 29, 2024

Язык: Английский

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The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential

Medical Oncology, Год журнала: 2025, Номер 42(6)

Опубликована: Май 5, 2025

Язык: Английский

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A novel nomogram based on inflammatory-nutritional biomarkers for gallbladder cancer after surgical resection

BMC Gastroenterology, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 27, 2024

Systemic inflammation and nutrition are vital for tumor progression. This study aimed to identify prognostic markers develop a predictive nomogram gallbladder cancer (GBC). A total of 123 patients with GBC who underwent surgical resection at the First Affiliated Hospital Soochow University Suzhou Kowloon were included in our study. The final variables identified using univariate multivariate analyses. model was then established, consistency index (C-index), calibration curves, Kaplan–Meier analysis performed evaluate accuracy discrimination nomogram. area under receiver operating characteristic curve (AUC) decision (DCA) suggested that had better ability clinical feasibility than published model. cox regression showed carcinoembryonic antigen (CEA) > 4.580, albumin-bilirubin (ALBI) –2.091, geriatric nutritional risk (GNRI) < 90.83, T3–T4, N2 independent factors. constructed C-index 0.793. In nomogram-predicted 1-, 3-, 5-year survival matched well actual survival. high-risk group worse low-risk (P 0.001). Finally, achieved 3- AUCs an established (0.871, 0.844, 0.781 vs. 0.753, 0.750, 0.693). DCA also confirmed outperformed conclusion, revealed CEA GNRI ALBI T3–T4 stage, related outcomes after resection. has superior practicality.

Язык: Английский

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Impact on Human Health of Salmonella spp. and Their Lipopolysaccharides: Possible Therapeutic Role and Asymptomatic Presence Consequences

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11868 - 11868

Опубликована: Ноя. 5, 2024

Epidemiologically, one of the most important concerns associated with introducing

Язык: Английский

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A Review of the Relationship between Tumors of the Biliary System and Intestinal Microorganisms

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(07), С. 833 - 840

Опубликована: Янв. 1, 2024

Язык: Английский

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A Rare Case of Granulicatella adiacens Gallbladder Abscess Associated With Gallbladder Adenocarcinoma: Diagnostic and Therapeutic Challenges

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Авг. 19, 2024

, a nutritionally variant streptococcus, is part of the normal oral, gastrointestinal, and urogenital flora. It associated with bacteremia, infectious endocarditis, and, rarely, bone joint infections.

Язык: Английский

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Helicobacter pylori Infection and Cholelithiasis

Journal of Gastroenterology and Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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