A Rare Case of Granulicatella adiacens Gallbladder Abscess Associated With Gallbladder Adenocarcinoma: Diagnostic and Therapeutic Challenges DOI Open Access

Heather L Mateja,

Rubén Neris,

Pablo Giuseppucci

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

, a nutritionally variant streptococcus, is part of the normal oral, gastrointestinal, and urogenital flora. It associated with bacteremia, infectious endocarditis, and, rarely, bone joint infections.

Language: Английский

Precision medicine for personalized cholecystitis care: integrating molecular diagnostics and biotherapeutics DOI Creative Commons

Tamer A. Addissouky

Bulletin of the National Research Centre/Bulletin of the National Research Center, Journal Year: 2024, Volume and Issue: 48(1)

Published: Sept. 12, 2024

Abstract Background Acute cholecystitis, inflammation of the gallbladder, can lead to serious complications if not promptly diagnosed and managed. Conventional therapies have limitations, necessitating newer personalized approaches. Main body abstract This review examines recent advances transforming cholecystitis care. Diagnostically, molecular techniques like next-generation sequencing rapidly identify causative microbes from gallbladder specimens, enabling targeted antimicrobial therapy. Regarding treatment, phage therapy uses viruses lyse pathogenic bacteria. RNA interference CRISPR-Cas9 gene editing silence microbial virulence factors. Probiotics competitively exclude pathogens. Robotics fluorescence imaging refine surgical techniques. Additional emerging modalities include biosensors detecting inflammatory mediators, regenerative tissue engineering using stem cells, artificial intelligence for real-time decision support. However, optimal integration novel technologies with current best practices remains unknown. Further research is needed validate optimize diagnostics therapeutics cholecystitis. Short conclusions Advances in sequencing, CRISPR editing, robotics, other biotechnologies promise transform precision management when thoughtfully implemented. controlled trials are still required define conventional supportive care antibiotics.

Language: Английский

Citations

5
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential DOI

Neelakanta Sarvashiva Kiran,

Ankita Chatterjee,

Chandrashekar Yashaswini

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 5, 2025

Language: Английский

Citations

0
Glucosinolates and Indole-3-carbinol from Brassica oleracea L. as inhibitors of E. coli CdtB: insights from molecular docking, dynamics, DFT and in vitro assay DOI
Faria Tasnim, Md. Eram Hosen,

Md. Enamul Haque

et al.

In Silico Pharmacology, Journal Year: 2024, Volume and Issue: 12(2)

Published: Oct. 29, 2024

Language: Английский

Citations

3
A novel nomogram based on inflammatory-nutritional biomarkers for gallbladder cancer after surgical resection DOI Creative Commons
Xueqing Yin,

Xinren Ma,

Pu Sun

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 27, 2024

Systemic inflammation and nutrition are vital for tumor progression. This study aimed to identify prognostic markers develop a predictive nomogram gallbladder cancer (GBC). A total of 123 patients with GBC who underwent surgical resection at the First Affiliated Hospital Soochow University Suzhou Kowloon were included in our study. The final variables identified using univariate multivariate analyses. model was then established, consistency index (C-index), calibration curves, Kaplan–Meier analysis performed evaluate accuracy discrimination nomogram. area under receiver operating characteristic curve (AUC) decision (DCA) suggested that had better ability clinical feasibility than published model. cox regression showed carcinoembryonic antigen (CEA) > 4.580, albumin-bilirubin (ALBI) –2.091, geriatric nutritional risk (GNRI) < 90.83, T3–T4, N2 independent factors. constructed C-index 0.793. In nomogram-predicted 1-, 3-, 5-year survival matched well actual survival. high-risk group worse low-risk (P 0.001). Finally, achieved 3- AUCs an established (0.871, 0.844, 0.781 vs. 0.753, 0.750, 0.693). DCA also confirmed outperformed conclusion, revealed CEA GNRI ALBI T3–T4 stage, related outcomes after resection. has superior practicality.

Language: Английский

Citations

1
Impact on Human Health of Salmonella spp. and Their Lipopolysaccharides: Possible Therapeutic Role and Asymptomatic Presence Consequences DOI Open Access
Mateusz Mikołajczyk, Dagmara Złotkowska, Anita Mikołajczyk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11868 - 11868

Published: Nov. 5, 2024

Epidemiologically, one of the most important concerns associated with introducing

Language: Английский

Citations

1
Helicobacter pylori Infection and Cholelithiasis DOI
Evangelos Kazakos, Jannis Kountouras

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

Citations

0
A Review of the Relationship between Tumors of the Biliary System and Intestinal Microorganisms DOI

勇利 李

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(07), P. 833 - 840

Published: Jan. 1, 2024

Language: Английский

Citations

0
A Rare Case of Granulicatella adiacens Gallbladder Abscess Associated With Gallbladder Adenocarcinoma: Diagnostic and Therapeutic Challenges DOI Open Access

Heather L Mateja,

Rubén Neris,

Pablo Giuseppucci

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

, a nutritionally variant streptococcus, is part of the normal oral, gastrointestinal, and urogenital flora. It associated with bacteremia, infectious endocarditis, and, rarely, bone joint infections.

Language: Английский

Citations

0