Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

Cardiovascular Diabetology, Год журнала: 2022, Номер 21(1)

Опубликована: Июль 1, 2022

Abstract Background The triglyceride-glucose (TyG) index is a new alternative measure for insulin resistance. This meta-analysis was conducted to assess the associations of TyG with risks cardiovascular diseases and mortality in general population. Methods PubMed, Cochrane Library Embase databases were searched randomized controlled trials or observational cohort studies reporting from inception April 16, 2022. Effect sizes pooled using random-effects models. Robust error meta-regression methods applied fit nonlinear dose–response associations. Evidence quality levels recommendations assessed Grading Recommendations Assessment, Development Evaluation system (GRADE). Results Twelve (6 prospective 6 retrospective cohorts) involving 6,354,990 participants included this meta-analysis. Compared lowest category, highest related higher incidence coronary artery disease (CAD) (3 studies; hazard ratio [HR] = 2.01; 95% confidence interval [CI] 1.68–2.40; I 2 0%), myocardial infarction (MI) (2 HR 1.36; CI 1.18–1.56; 35%), composite (CVD) (5 1.46; 1.23–1.74; 82%). However, there no association between (cardiovascular [3 1.10; 0.82–1.47; 76%] all-cause [4 1.08; 0.92–1.27; 87%]). In analysis, linear risk CAD (P 0.3807) CVD 0.0612). GRADE assessment indicated very low certainty CVD, MI, mortality, moderate CAD. Conclusions Based on our current evidence, may be associated an increased (moderate certainty), MI (very certainty) There potential incidence. Further (especially non-Asians) are needed confirm findings.

Язык: Английский

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Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data

Cardiovascular Diabetology, Год журнала: 2023, Номер 22(1)

Опубликована: Фев. 16, 2023

Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated predict cardiovascular disease (CVD). However, very few studies investigated their associations with CVD in European populations. Methods A total 403,335 participants from the UK Biobank data for TyG TG/HDL-C ratio free at baseline were included. Cox models applied evaluate association between incident CVD. Mediation analyses performed contribution prevalent diabetes, hypertension, dyslipidemia observed associations. Results During a median follow-up 8.1 years, 19,754 (4.9%) individuals developed CVD, including 16,404 (4.1%) cases CHD 3976 (1.0%) stroke. multivariable-adjusted hazard ratios higher quartiles versus lowest 1.05, 1.19, respectively, index, 1.07, 1.13, 1.29, ratio. There significant trends toward an increasing risk across In mediation analyses, dyslipidemia, type 2 hypertension explained 45.8%, 27.0%, 15.0% index’s 40.0%, 11.8%, 13.3% ratio’s respectively. Conclusions Elevated associated after adjustment well-established factors. These largely mediated by greater prevalence hypertension.

Язык: Английский

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Triglyceride-glucose index trajectory and stroke incidence in patients with hypertension: a prospective cohort study

Cardiovascular Diabetology, Год журнала: 2022, Номер 21(1)

Опубликована: Июль 27, 2022

Abstract Background It has been suggested that the baseline triglyceride-glucose (TyG) index, a simple surrogate measure for insulin resistance, is significantly associated with occurrence of stroke. Nevertheless, impact longitudinal patterns TyG on stroke risk in hypertensive patients still unknown. Hence, this study aimed to investigate association between index trajectory and among patients. Methods This prospective included 19,924 from Kailuan Study who underwent three waves survey were free myocardial infarction, cancer before or during 2010. The was calculated as ln [fasting triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2], latent mixed modelling used identify exposure period (2006–2010). Furthermore, Cox proportional hazard models applied estimate ratio (HR) 95% confidence interval (CI) incident different groups. Results Five distinct identified 2006–2010: low-stable (n = 2483; range, 8.03–8.06), moderate 9666; 8.58–8.57), high-stable 5759; 9.16–9.09), elevated-stable 1741; 9.79–9.75), elevated-increasing 275; 10.38–10.81). During median follow-up 9.97 years, 1,519 cases identified, including 1,351 ischemic 215 hemorrhage After adjusting confounding variables, HR CI 2.21 (1.49,3.28) group, 1.43 (1.13,1.83) 1.35 (1.10,1.64) 1.26 (1.06,1.52) respectively, when compare group. Similar results observed stroke, but significant not found Conclusion A long-term elevated an increased especially finding implies regular monitoring may assist identifying individuals at higher hypertension.

Язык: Английский

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The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2022, Номер 32(12), С. 2677 - 2688

Опубликована: Сен. 2, 2022

Язык: Английский

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Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 23, 2024

The present umbrella review aims to collate and summarize the findings from previous meta-analyses on Triglyceride Glucose (TyG) Index, providing insights clinicians, researchers, policymakers regarding usefulness of this biomarker in various clinical settings. A comprehensive search was conducted PubMed, Scopus, Web Science up April 14, 2024, without language restrictions. AMSTAR2 checklist assessed methodological quality included meta-analyses. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software. total 32 studies finally included. results revealed significant associations between TyG index health outcomes. For kidney outcomes, a high significantly associated with an increased risk contrast-induced nephropathy (CIN) (OR = 2.24, 95% CI: 1.82–2.77) chronic disease (CKD) (RR 1.46, 1.32–1.63). High type 2 diabetes mellitus (T2DM) 3.53, 2.74–4.54), gestational (GDM) 2.41, 1.48–3.91), diabetic retinopathy (DR) 2.34, 1.31–4.19). Regarding metabolic diseases, higher patients obstructive sleep apnea (OSA) (SMD 0.86, 0.57–1.15), syndrome (MD 0.83, 0.74–0.93), non-alcoholic fatty liver (NAFLD) 2.36, 1.88–2.97) compared those these conditions. In cerebrovascular dementia 1.14, 1.12–1.16), cognitive impairment 2.31, 1.38–3.86), ischemic stroke 1.37, 1.22–1.54). cardiovascular showed heart failure (HF) (HR 1.21, 1.12–1.30), atrial fibrillation (AF) 1.22, 0.57–1.87), hypertension (HTN) 1.52, 1.25–1.85). is promising for screening predicting medical conditions, particularly related insulin resistance disorders. However, heterogeneity suggest need further high-quality research confirm refine utility index.

Язык: Английский

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Assessing the association between triglyceride-glucose index and atrial fibrillation: a systematic review and meta-analysis

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Фев. 12, 2024

Abstract Background An essential relationship between insulin resistance (IR) and atrial fibrillation (AF) has been demonstrated. Among the methods used to assess IR, triglyceride-glucose (TyG) index is more straightforward, dimensionless, low-cost tool. However, possible usage of this in clinical practice predict diagnose AF yet be determined consolidated. Objective rationale Herein, we performed a systematic review meta-analysis association TyG AF. Methods Databases (PubMed, Embase, Scopus, Web Science) were systematically searched for studies evaluating The inclusion criteria observational investigating correlation individuals older than 18 years, while preclinical those without relevant data excluded. Random effect meta-analyses comparing levels non-AF cases, recurrence after radiofrequency ablation, post-procedural using standardized mean differences (SMD) with their matching 95% confidence intervals (CIs). Results Our screening identified nine analyzed, including 6,171 participants 886 demonstrated that resulted higher patients counterparts (SMD 1.23, CI 0.71 1.75, I 2 98%, P < 0.001). Subgroup analysis showed same results post-procedure 0.99, 0.78 1.20, 10%, 0.001) post-ablation 1.25, 1.07 1.43, 46%, 0.001), no difference was found population-based cohorts 1.45, − 0.41 3.31, 100%, = 0.13). Publication year ( 0.036) sample size 0.003) significant associations size, multivariable meta-regression. Conclusion an easy-to-measure surrogate marker IR Further are warranted demonstrate its ability routine use as

Язык: Английский

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Link between triglyceride-glucose-body mass index and future stroke risk in middle-aged and elderly chinese: a nationwide prospective cohort study

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Фев. 24, 2024

Abstract Objective Current literature is deficient in robust evidence delineating the correlation between triglyceride glucose-body mass index (TyG-BMI) and incidence of stroke. Consequently, this investigation seeks to elucidate potential link TyG-BMI stroke risk a cohort middle-aged senior Chinese individuals. Methods This study employs longitudinal data from four waves China Health Retirement Longitudinal Study (CHARLS) conducted 2011, 2013, 2015, 2018, encompassing 8,698 participants. The CHARLS was assembled using multistage probability sampling technique. Participants underwent comprehensive evaluations through standardized questionnaires administered via face-to-face interviews. Our analytic strategy involved application Cox proportional hazards regression models investigate association To discern non-linear relationships, we incorporated with smooth curve fitting. Additionally, executed battery sensitivity subgroup analyses validate robustness our findings. Results utilized multivariate model found significant Specifically, 10-unit increase corresponded 4.9% heightened (HR = 1.049, 95% CI 1.029–1.069). analysis also uncovered pattern relationship, pinpointed by an inflection point at value 174.63. left point—meaning lower values—a hike linked more substantial 14.4% rise 1.144; 1.044–1.253). Conversely, right point—at higher values—each increment associated smaller, 3.8% 1.038; 1.016–1.061). Conclusions In elderly population, elevated significantly positively risk. addition, there specific (inflection 174.63). Further reduction below 174.63 lifestyle changes dietary control can reduce

Язык: Английский

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Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 7, 2024

The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome, which is result an increasing emphasis on interplay metabolic, renal and cardiovascular diseases (CVD). Furthermore, there substantial evidence a correlation between triglyceride glucose-body mass index (TyG-BMI ) CVD as assessment insulin resistance (IR). However, it remains unknown whether this exists in population with CKM syndrome.

Язык: Английский

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Comparison of seven surrogate insulin resistance indexes for prediction of incident coronary heart disease risk: a 10-year prospective cohort study

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Янв. 23, 2024

Background There were seven novel and easily accessed insulin resistance (IR) surrogates established, including the Chinese visceral adiposity index (CVAI), (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, TyG-body mass (TyG-BMI), TyG-waist circumference (TyG-WC) to height ratio (TyG-WHtR). We aimed explore association between IR incident coronary heart disease (CHD), compare their predictive powers among population. Methods This is a 10-year prospective cohort study conducted in China 6393 participants without cardiovascular (CVD) at baseline. developed Cox regression analyses examine of with CHD (hazard [HR], 95% confidence intervals [CI]). Moreover, receiver operating characteristic (ROC) curve was performed values these indexes for by areas under ROC (AUC). Results During median follow-up period 10.25 years, 246 individuals newly CHD. Significant associations (excepted VAI) found our after fully adjustment, fifth quintile HRs (95% CIs) respectively 2.055(1.216-3.473), 1.446(0.948-2.205), 1.753(1.099-2.795), 2.013(1.214-3.339), 3.169(1.926-5.214), 2.275(1.391-3.719) 2.309(1.419-3.759) CVAI, VAI, LAP, TyG, TyG-BMI, TyG-WC TyG-WHtR, compared 1. Furthermore, CVAI showed maximum capacity largest AUC: 0.632(0.597,0.667). Conclusion The independently associated higher prevalence CHD, which most powerful predictor incidence populations.

Язык: Английский

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Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 15, 2025

The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both and mortality. In recent years, TyG-obesity-related parameters have gained special attention in this regard. This study aimed to assess association between TyG-waist circumference (TyG-WC) A comprehensive search was performed databases including PubMed, Scopus, Web Science from their inception until October 6, 2024. key outcomes interest included all-cause mortality, diseases, myocardial infarction, stroke, coronary artery peripheral heart failure. pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) calculated. Meta-analysis carried out using StataMP 14.0. total 17 studies were analysis. number participants ranged 2,224 95,342. meta-analysis revealed TyG-WC is significantly associated an increased diseases. However, only one addressed relationship failure a positive correlation. indicates could serve as promising predictor along Given its accessibility, may be practical tool screening purposes.

Язык: Английский

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