BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Март 19, 2024
Abstract
Aim
Insulin
resistance
(IR)
may
participate
in
the
pathogenesis
of
hypertension
by
mediating
low-grade
systemic
inflammation.
The
triglycerides-glucose
(TyG)
index
has
recently
been
suggested
as
a
reliable
alternative
biochemical
marker
IR
compared
with
traditional
methods.
Herein,
we
speculated
TyG
also
be
associated
hypertension.
Methods
Data
adults
were
extracted
from
China
Health
and
Nutrition
Survey
(CHNS)
2009–2015
this
retrospective
cohort
study.
was
calculated
using
formula:
=
Ln
[fasting
triglycerides
(mg/dL)
×fasting
glucose
(mg/dL)/2].
Associations
between
evaluated
univariate
multivariate
logistic
regression
analyses
odds
ratios
(ORs)
95%
confidence
intervals
(CIs).
Subgroup
age
gender
performed.
In
addition,
assessed
interaction
effect
body
mass
(BMI)
on
participants
different
gender.
Results
Among
3,413
eligible
participants,
1,627
(47.67%)
developed
average
group
non-hypertension
8.58
8.39
respectively.
After
adjusting
for
covariates,
found
that
≤
8.41
(median
value),
those
who
had
higher
seemed
to
have
[OR
1.17,
95%CI:
(1.01–1.37)].
Similarly,
association
discovered
aged
65
years
old
1.19,
(1.01–1.39)]
or
female
1.35,
(1.10–1.65)].
Additionally,
there
potential
additive
obesity
Conclusion
High
high
general
population
China,
but
causal
relationship
them
needed
further
exploration.
Cardiovascular Diabetology,
Год журнала:
2022,
Номер
21(1)
Опубликована: Июль 1, 2022
Abstract
Background
The
triglyceride-glucose
(TyG)
index
is
a
new
alternative
measure
for
insulin
resistance.
This
meta-analysis
was
conducted
to
assess
the
associations
of
TyG
with
risks
cardiovascular
diseases
and
mortality
in
general
population.
Methods
PubMed,
Cochrane
Library
Embase
databases
were
searched
randomized
controlled
trials
or
observational
cohort
studies
reporting
from
inception
April
16,
2022.
Effect
sizes
pooled
using
random-effects
models.
Robust
error
meta-regression
methods
applied
fit
nonlinear
dose–response
associations.
Evidence
quality
levels
recommendations
assessed
Grading
Recommendations
Assessment,
Development
Evaluation
system
(GRADE).
Results
Twelve
(6
prospective
6
retrospective
cohorts)
involving
6,354,990
participants
included
this
meta-analysis.
Compared
lowest
category,
highest
related
higher
incidence
coronary
artery
disease
(CAD)
(3
studies;
hazard
ratio
[HR]
=
2.01;
95%
confidence
interval
[CI]
1.68–2.40;
I
2
0%),
myocardial
infarction
(MI)
(2
HR
1.36;
CI
1.18–1.56;
35%),
composite
(CVD)
(5
1.46;
1.23–1.74;
82%).
However,
there
no
association
between
(cardiovascular
[3
1.10;
0.82–1.47;
76%]
all-cause
[4
1.08;
0.92–1.27;
87%]).
In
analysis,
linear
risk
CAD
(P
0.3807)
CVD
0.0612).
GRADE
assessment
indicated
very
low
certainty
CVD,
MI,
mortality,
moderate
CAD.
Conclusions
Based
on
our
current
evidence,
may
be
associated
an
increased
(moderate
certainty),
MI
(very
certainty)
There
potential
incidence.
Further
(especially
non-Asians)
are
needed
confirm
findings.
Cardiovascular Diabetology,
Год журнала:
2023,
Номер
22(1)
Опубликована: Фев. 16, 2023
Abstract
Background
The
triglyceride-glucose
(TyG)
index
and
triglyceride
to
high-density
lipoprotein
cholesterol
(TG/HDL-C)
ratio,
two
simple
surrogate
indicators
of
insulin
resistance,
have
been
demonstrated
predict
cardiovascular
disease
(CVD).
However,
very
few
studies
investigated
their
associations
with
CVD
in
European
populations.
Methods
A
total
403,335
participants
from
the
UK
Biobank
data
for
TyG
TG/HDL-C
ratio
free
at
baseline
were
included.
Cox
models
applied
evaluate
association
between
incident
CVD.
Mediation
analyses
performed
contribution
prevalent
diabetes,
hypertension,
dyslipidemia
observed
associations.
Results
During
a
median
follow-up
8.1
years,
19,754
(4.9%)
individuals
developed
CVD,
including
16,404
(4.1%)
cases
CHD
3976
(1.0%)
stroke.
multivariable-adjusted
hazard
ratios
higher
quartiles
versus
lowest
1.05,
1.19,
respectively,
index,
1.07,
1.13,
1.29,
ratio.
There
significant
trends
toward
an
increasing
risk
across
In
mediation
analyses,
dyslipidemia,
type
2
hypertension
explained
45.8%,
27.0%,
15.0%
index’s
40.0%,
11.8%,
13.3%
ratio’s
respectively.
Conclusions
Elevated
associated
after
adjustment
well-established
factors.
These
largely
mediated
by
greater
prevalence
hypertension.
Cardiovascular Diabetology,
Год журнала:
2022,
Номер
21(1)
Опубликована: Июль 27, 2022
Abstract
Background
It
has
been
suggested
that
the
baseline
triglyceride-glucose
(TyG)
index,
a
simple
surrogate
measure
for
insulin
resistance,
is
significantly
associated
with
occurrence
of
stroke.
Nevertheless,
impact
longitudinal
patterns
TyG
on
stroke
risk
in
hypertensive
patients
still
unknown.
Hence,
this
study
aimed
to
investigate
association
between
index
trajectory
and
among
patients.
Methods
This
prospective
included
19,924
from
Kailuan
Study
who
underwent
three
waves
survey
were
free
myocardial
infarction,
cancer
before
or
during
2010.
The
was
calculated
as
ln
[fasting
triglyceride
(mg/dL)
×
fasting
plasma
glucose
(mg/dL)/2],
latent
mixed
modelling
used
identify
exposure
period
(2006–2010).
Furthermore,
Cox
proportional
hazard
models
applied
estimate
ratio
(HR)
95%
confidence
interval
(CI)
incident
different
groups.
Results
Five
distinct
identified
2006–2010:
low-stable
(n
=
2483;
range,
8.03–8.06),
moderate
9666;
8.58–8.57),
high-stable
5759;
9.16–9.09),
elevated-stable
1741;
9.79–9.75),
elevated-increasing
275;
10.38–10.81).
During
median
follow-up
9.97
years,
1,519
cases
identified,
including
1,351
ischemic
215
hemorrhage
After
adjusting
confounding
variables,
HR
CI
2.21
(1.49,3.28)
group,
1.43
(1.13,1.83)
1.35
(1.10,1.64)
1.26
(1.06,1.52)
respectively,
when
compare
group.
Similar
results
observed
stroke,
but
significant
not
found
Conclusion
A
long-term
elevated
an
increased
especially
finding
implies
regular
monitoring
may
assist
identifying
individuals
at
higher
hypertension.
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Авг. 23, 2024
The
present
umbrella
review
aims
to
collate
and
summarize
the
findings
from
previous
meta-analyses
on
Triglyceride
Glucose
(TyG)
Index,
providing
insights
clinicians,
researchers,
policymakers
regarding
usefulness
of
this
biomarker
in
various
clinical
settings.
A
comprehensive
search
was
conducted
PubMed,
Scopus,
Web
Science
up
April
14,
2024,
without
language
restrictions.
AMSTAR2
checklist
assessed
methodological
quality
included
meta-analyses.
Statistical
analyses
were
performed
using
Comprehensive
Meta-Analysis
(CMA)
software.
total
32
studies
finally
included.
results
revealed
significant
associations
between
TyG
index
health
outcomes.
For
kidney
outcomes,
a
high
significantly
associated
with
an
increased
risk
contrast-induced
nephropathy
(CIN)
(OR
=
2.24,
95%
CI:
1.82–2.77)
chronic
disease
(CKD)
(RR
1.46,
1.32–1.63).
High
type
2
diabetes
mellitus
(T2DM)
3.53,
2.74–4.54),
gestational
(GDM)
2.41,
1.48–3.91),
diabetic
retinopathy
(DR)
2.34,
1.31–4.19).
Regarding
metabolic
diseases,
higher
patients
obstructive
sleep
apnea
(OSA)
(SMD
0.86,
0.57–1.15),
syndrome
(MD
0.83,
0.74–0.93),
non-alcoholic
fatty
liver
(NAFLD)
2.36,
1.88–2.97)
compared
those
these
conditions.
In
cerebrovascular
dementia
1.14,
1.12–1.16),
cognitive
impairment
2.31,
1.38–3.86),
ischemic
stroke
1.37,
1.22–1.54).
cardiovascular
showed
heart
failure
(HF)
(HR
1.21,
1.12–1.30),
atrial
fibrillation
(AF)
1.22,
0.57–1.87),
hypertension
(HTN)
1.52,
1.25–1.85).
is
promising
for
screening
predicting
medical
conditions,
particularly
related
insulin
resistance
disorders.
However,
heterogeneity
suggest
need
further
high-quality
research
confirm
refine
utility
index.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Фев. 12, 2024
Abstract
Background
An
essential
relationship
between
insulin
resistance
(IR)
and
atrial
fibrillation
(AF)
has
been
demonstrated.
Among
the
methods
used
to
assess
IR,
triglyceride-glucose
(TyG)
index
is
more
straightforward,
dimensionless,
low-cost
tool.
However,
possible
usage
of
this
in
clinical
practice
predict
diagnose
AF
yet
be
determined
consolidated.
Objective
rationale
Herein,
we
performed
a
systematic
review
meta-analysis
association
TyG
AF.
Methods
Databases
(PubMed,
Embase,
Scopus,
Web
Science)
were
systematically
searched
for
studies
evaluating
The
inclusion
criteria
observational
investigating
correlation
individuals
older
than
18
years,
while
preclinical
those
without
relevant
data
excluded.
Random
effect
meta-analyses
comparing
levels
non-AF
cases,
recurrence
after
radiofrequency
ablation,
post-procedural
using
standardized
mean
differences
(SMD)
with
their
matching
95%
confidence
intervals
(CIs).
Results
Our
screening
identified
nine
analyzed,
including
6,171
participants
886
demonstrated
that
resulted
higher
patients
counterparts
(SMD
1.23,
CI
0.71
1.75,
I
2
98%,
P
<
0.001).
Subgroup
analysis
showed
same
results
post-procedure
0.99,
0.78
1.20,
10%,
0.001)
post-ablation
1.25,
1.07
1.43,
46%,
0.001),
no
difference
was
found
population-based
cohorts
1.45,
−
0.41
3.31,
100%,
=
0.13).
Publication
year
(
0.036)
sample
size
0.003)
significant
associations
size,
multivariable
meta-regression.
Conclusion
an
easy-to-measure
surrogate
marker
IR
Further
are
warranted
demonstrate
its
ability
routine
use
as
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Фев. 24, 2024
Abstract
Objective
Current
literature
is
deficient
in
robust
evidence
delineating
the
correlation
between
triglyceride
glucose-body
mass
index
(TyG-BMI)
and
incidence
of
stroke.
Consequently,
this
investigation
seeks
to
elucidate
potential
link
TyG-BMI
stroke
risk
a
cohort
middle-aged
senior
Chinese
individuals.
Methods
This
study
employs
longitudinal
data
from
four
waves
China
Health
Retirement
Longitudinal
Study
(CHARLS)
conducted
2011,
2013,
2015,
2018,
encompassing
8,698
participants.
The
CHARLS
was
assembled
using
multistage
probability
sampling
technique.
Participants
underwent
comprehensive
evaluations
through
standardized
questionnaires
administered
via
face-to-face
interviews.
Our
analytic
strategy
involved
application
Cox
proportional
hazards
regression
models
investigate
association
To
discern
non-linear
relationships,
we
incorporated
with
smooth
curve
fitting.
Additionally,
executed
battery
sensitivity
subgroup
analyses
validate
robustness
our
findings.
Results
utilized
multivariate
model
found
significant
Specifically,
10-unit
increase
corresponded
4.9%
heightened
(HR
=
1.049,
95%
CI
1.029–1.069).
analysis
also
uncovered
pattern
relationship,
pinpointed
by
an
inflection
point
at
value
174.63.
left
point—meaning
lower
values—a
hike
linked
more
substantial
14.4%
rise
1.144;
1.044–1.253).
Conversely,
right
point—at
higher
values—each
increment
associated
smaller,
3.8%
1.038;
1.016–1.061).
Conclusions
In
elderly
population,
elevated
significantly
positively
risk.
addition,
there
specific
(inflection
174.63).
Further
reduction
below
174.63
lifestyle
changes
dietary
control
can
reduce
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Авг. 7, 2024
The
American
Heart
Association
(AHA)
has
recently
introduced
the
concept
of
Cardiovascular-Kidney-Metabolic
(CKM)
syndrome,
which
is
result
an
increasing
emphasis
on
interplay
metabolic,
renal
and
cardiovascular
diseases
(CVD).
Furthermore,
there
substantial
evidence
a
correlation
between
triglyceride
glucose-body
mass
index
(TyG-BMI
)
CVD
as
assessment
insulin
resistance
(IR).
However,
it
remains
unknown
whether
this
exists
in
population
with
CKM
syndrome.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 23, 2024
Background
There
were
seven
novel
and
easily
accessed
insulin
resistance
(IR)
surrogates
established,
including
the
Chinese
visceral
adiposity
index
(CVAI),
(VAI),
lipid
accumulation
product
(LAP),
triglyceride
glucose
(TyG)
index,
TyG-body
mass
(TyG-BMI),
TyG-waist
circumference
(TyG-WC)
to
height
ratio
(TyG-WHtR).
We
aimed
explore
association
between
IR
incident
coronary
heart
disease
(CHD),
compare
their
predictive
powers
among
population.
Methods
This
is
a
10-year
prospective
cohort
study
conducted
in
China
6393
participants
without
cardiovascular
(CVD)
at
baseline.
developed
Cox
regression
analyses
examine
of
with
CHD
(hazard
[HR],
95%
confidence
intervals
[CI]).
Moreover,
receiver
operating
characteristic
(ROC)
curve
was
performed
values
these
indexes
for
by
areas
under
ROC
(AUC).
Results
During
median
follow-up
period
10.25
years,
246
individuals
newly
CHD.
Significant
associations
(excepted
VAI)
found
our
after
fully
adjustment,
fifth
quintile
HRs
(95%
CIs)
respectively
2.055(1.216-3.473),
1.446(0.948-2.205),
1.753(1.099-2.795),
2.013(1.214-3.339),
3.169(1.926-5.214),
2.275(1.391-3.719)
2.309(1.419-3.759)
CVAI,
VAI,
LAP,
TyG,
TyG-BMI,
TyG-WC
TyG-WHtR,
compared
1.
Furthermore,
CVAI
showed
maximum
capacity
largest
AUC:
0.632(0.597,0.667).
Conclusion
The
independently
associated
higher
prevalence
CHD,
which
most
powerful
predictor
incidence
populations.
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 15, 2025
The
significant
burden
of
cardiovascular
diseases
underscores
the
necessity
for
identifying
novel
predictive
markers
that
can
forecast
both
and
mortality.
In
recent
years,
TyG-obesity-related
parameters
have
gained
special
attention
in
this
regard.
This
study
aimed
to
assess
association
between
TyG-waist
circumference
(TyG-WC)
A
comprehensive
search
was
performed
databases
including
PubMed,
Scopus,
Web
Science
from
their
inception
until
October
6,
2024.
key
outcomes
interest
included
all-cause
mortality,
diseases,
myocardial
infarction,
stroke,
coronary
artery
peripheral
heart
failure.
pooled
risk
ratio
(RR)
with
corresponding
95%
confidence
intervals
(CI)
calculated.
Meta-analysis
carried
out
using
StataMP
14.0.
total
17
studies
were
analysis.
number
participants
ranged
2,224
95,342.
meta-analysis
revealed
TyG-WC
is
significantly
associated
an
increased
diseases.
However,
only
one
addressed
relationship
failure
a
positive
correlation.
indicates
could
serve
as
promising
predictor
along
Given
its
accessibility,
may
be
practical
tool
screening
purposes.