Current Problems in Cardiology, Год журнала: 2023, Номер 49(3), С. 102128 - 102128
Опубликована: Окт. 5, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(5), С. 2617 - 2617
Опубликована: Фев. 27, 2022
Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in interstitium. It an essential pathological response to chronic inflammation. ECM protein initially protective and critical for wound healing tissue regeneration. However, cardiac remodeling continuous damage with subsequent results a distorted organ architecture significantly impacts function. In this review, we summarized discussed histologic features fibrosis signaling factors that control it. We evaluated origin characteristic markers fibroblasts. also lymphatic vessels, which have become more important recent years improve fibrosis.
Язык: Английский
Процитировано
121
International Journal of Cardiology, Год журнала: 2024, Номер 418, С. 132663 - 132663
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
17
Annals of Medicine and Surgery, Год журнала: 2022, Номер 76
Опубликована: Март 21, 2022
Doxorubicin (DOX) is a commonly used treatment for cancer and the mechanism of DOX-induced cardiomyocyte damage in cardiovascular disease not fully understood. High-mobility group box 1 (HMGB1), strong induce proinflammatory cytokines via associated molecular pattern (DAMP) which its interaction with receptor advanced glycation end products (RAGE), that affect cytokine release, angiogenesis role HMBG1, HIF-1α VEGF as an important regulator these cardiac failure processes. Hypoxia-inducible factor-1α (HIF-1α) plays cellular response to systemic oxygen levels cells angiogenic factor can stimulate responses on surface endothelial will be described.The aim this article comprehensively review HMGB1, HIF-1α, Cardiovascular Disease mechanisms.The data study were collect by search keyword combinations medical subject headings (MeSH) "HMGB1", "HIF-1 α", "VEGF", "DOX" "Cardiovascular disease" relevant reference lists manually searched PubMed, EMBASE Scopus database. All articles base above included narratively discussed article.Several revealed mechanisms DOX related may potential prevention intervention.HMGB1, has pivotal DOX-induce predominantly acts through different pathways. The HMGB1 myocardial suggests mediator damage. In addition, inhibit activity where decrease expression also responsible upregulation several factors, including VEGF. anti-angiogenesis both vitro vivo reduces side effects markedly. administration show inhibitory effect mediated signaling pathway triggered cells.
Язык: Английский
Процитировано
41
Biomedicines, Год журнала: 2023, Номер 11(4), С. 1126 - 1126
Опубликована: Апрель 7, 2023
Diabetes mellitus (DM) and cardiovascular complications are two unmet medical emergencies that can occur together. The rising incidence of heart failure in diabetic populations, addition to apparent coronary disease, ischemia, hypertension-related complications, has created a more challenging situation. Diabetes, as predominant cardio-renal metabolic syndrome, is related severe vascular risk factors, it underlies various complex pathophysiological pathways at the molecular level progress converge toward development cardiomyopathy (DCM). DCM involves several downstream cascades cause structural functional alterations heart, such diastolic dysfunction progressing into systolic dysfunction, cardiomyocyte hypertrophy, myocardial fibrosis, subsequent over time. effects glucagon-like peptide-1 (GLP-1) analogues sodium-glucose cotransporter-2 (SGLT-2) inhibitors on (CV) outcomes diabetes have shown promising results, including improved contractile bioenergetics significant benefits. purpose this article highlight pathophysiological, metabolic, contribute its cardiac morphology functioning. Additionally, will discuss potential therapies may be available future.
Язык: Английский
Процитировано
30
Heart Failure Reviews, Год журнала: 2023, Номер 28(5), С. 1065 - 1075
Опубликована: Апрель 28, 2023
The hypertrophic cardiomyopathy phenotype encompasses a heterogeneous spectrum of genetic and acquired diseases characterized by the presence left ventricular hypertrophy in absence abnormal cardiac loading conditions. This "umbrella diagnosis" includes "classic" (HCM), due to sarcomere protein gene mutations, its phenocopies caused intra- or extracellular deposits, such as Fabry disease (FD) amyloidosis (CA). All these conditions share wide phenotypic variability which results from combination environmental factors whose pathogenic mediators are poorly understood so far. Accumulating evidence suggests that inflammation plays critical role broad cardiovascular conditions, including cardiomyopathies. Indeed, can trigger molecular pathways contribute cardiomyocyte dysfunction, matrix accumulation, microvascular dysfunction. Growing systemic is possible key pathophysiologic process potentially involved pathogenesis progression, influencing severity clinical outcome, heart failure. In this review, we summarize current knowledge regarding prevalence, significance, potential therapeutic implications HCM two most important phenocopies, FD CA.
Язык: Английский
Процитировано
30
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6389 - 6389
Опубликована: Июнь 9, 2024
Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.
Язык: Английский
Процитировано
9
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 28, 2025
Cardiomyopathies are a heterogeneous group of disorders that can lead to fulminant heart failure and sudden cardiac death. In recent years, the prevalence all types cardiomyopathies has shown an upward trend globally. Up 40% patients with cardiomyopathy-related have diabetes mellitus (DM). With fast global spread DM, DCM is increasing accordingly it remains leading cause morbidity mortality in chronic diabetic patients. NLRP3 inflammasome significantly contributes development pathological progression DCM. Targeting or any mediators along its activation pathway provides new potential therapeutic targets for developing specialized drugs treat this comprehensive review, we sought introduce summarize non-coding RNAs effects targeting signaling We hope general overview aid future research therapies
Язык: Английский
Процитировано
1
Diabetes Care, Год журнала: 2022, Номер 45(11), С. 2644 - 2652
Опубликована: Сен. 22, 2022
OBJECTIVE The inflammatory cytokine interleukin-6 (IL-6) is associated with cardiovascular (CV) and kidney outcomes in various populations. However, data patients type 2 diabetes are limited. We assessed the association of IL-6 CV Canagliflozin Cardiovascular Assessment Study (CANVAS) determined effect canagliflozin on IL-6. RESEARCH DESIGN AND METHODS Patients at high risk were randomly assigned to or placebo. Plasma was measured baseline years 1, 3, 6. composite outcome nonfatal myocardial infarction, stroke, death; sustained ≥40% estimated glomerular filtration rate decline, end-stage disease, kidney-related death. Multivariable-adjusted Cox proportional hazards regression used estimate associations between outcomes. over time a repeated-measures mixed-effects model. RESULTS geometric mean baseline, available 3,503 (80.2%) participants, 1.7 pg/mL. Each doubling 14% (95% CI 4, 24) 21% 45) increased outcomes, respectively. Over 6 years, by 5.8% 3.4, 8.3) placebo group. modestly attenuated increase (absolute percentage difference vs. 4.4% [95% 1.3, 9.9; P = 0.01]). At year each 25% lower level compared 7% 22) 5, risks for outcome, CONCLUSIONS In risk, its 1-year change IL-6–lowering therapy CV, kidney, safety remains be tested.
Язык: Английский
Процитировано
32
Frontiers in Pharmacology, Год журнала: 2022, Номер 13
Опубликована: Март 22, 2022
Background: Gallic acid (GA) is a natural small-molecule polyphenol having wide range of pharmacological activities. Until now, some works have studied the effect and mechanisms GA against inflammation. However, whether or how gallic regulates downstream metabolic disorder acute inflammation remains unclear. The present study explored protective potential mechanism on through metabolomics approach. Methods: An rat model was induced by local injection carrageenin. Local swelling paw serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were assessed in Control, Model groups, respectively. Serum based high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) also established to collect rats' profiles explore changes related pretreatment. Results: Compared Modal group, pain, redness, carrageenin significantly alleviated groups addition dose-dependent decreases TNF-α IL-6. Metabolomics analysis found significant alterations signatures between carrageenin-induced control groups. Twelve biomarkers further identified principal component (PCA) partial least squares discrimination (PLS-DA). In addition, when rats pretreated acid, levels eleven observed restore partially. Metabolic pathway networks revealed that might invert pathological process regulating key involved linoleic metabolism, ascorbate aldarate pentose glucuronate interconversions, arachidonic (AA) metabolism pathways. Conclusion: elucidates its possible from metabolomic perspective. These results could provide theoretical basis for clarifying acid's medicinal value curing clinic.
Язык: Английский
Процитировано
29
Circulation, Год журнала: 2023, Номер 150(19), С. 1517 - 1532
Опубликована: Дек. 21, 2023
BACKGROUND: Metabolic distress is often associated with heart failure preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities HFpEF. How metabolic changes affect myocardial in the context of HFpEF not known. METHODS: We found that ApoE knockout mice fed Western diet recapitulate many features Single-cell RNA sequencing was used for expression analysis CD45 + cardiac cells to evaluate involvement diastolic dysfunction. focused bioinformatics on macrophages, obtaining high-resolution identification subsets these heart, enabling us study outcomes macrophage infiltrate identify macrophage-to-cardiomyocyte regulatory axis. To test whether clinically relevant sodium glucose cotransporter-2 inhibitor could ameliorate immune profile our model, were randomized receive dapagliflozin or vehicle 8 weeks. RESULTS: presented reduced function, exercise tolerance, increased pulmonary congestion lipid overload polyunsaturated fatty acids. The main cell types infiltrating included 4 subpopulations resident monocyte-derived determining proinflammatory exclusively knockout-Western mice. Lipid had direct effect inflammatory gene activation mediated through endoplasmic reticulum stress pathways. Investigation axis revealed potential effects cardiomyocytes multiple cytokines secreted by affecting pathways such as hypertrophy, fibrosis, autophagy. Finally, we describe an anti-inflammatory inhibition this model. CONCLUSIONS: Using single-cell model dysfunction driven hyperlipidemia, have determined cells, particular suggest inhibitors agents targeting specific phenotype
Язык: Английский
Процитировано
20