Viruses,
Год журнала:
2024,
Номер
16(7), С. 1060 - 1060
Опубликована: Июнь 30, 2024
Since
the
emergence
of
SARS-CoV-2
virus
in
2019,
nearly
700
million
COVID-19
cases
and
7
deaths
have
been
reported
globally.
Despite
most
individuals
recovering
within
four
weeks,
Center
for
Disease
Control
(CDC)
estimates
that
7.5%
to
41%
develop
post-acute
infection
syndrome
(PAIS),
known
as
'Long
COVID'.
This
review
provides
current
statistics
on
Long
COVID's
prevalence,
explores
hypotheses
concerning
epidemiological
factors,
such
age,
gender,
comorbidities,
initial
severity,
vaccine
interactions,
delves
into
potential
mechanisms,
including
immune
responses,
viral
persistence,
gut
dysbiosis.
Moreover,
we
conclude
women,
advanced
non-vaccination,
low
socioeconomic
status
all
appear
be
risk
factors.
The
reasons
these
differences
are
still
not
fully
understood
likely
involve
a
complex
relationship
between
social,
genetic,
hormonal,
other
Furthermore,
with
seem
more
endure
economic
hardship
due
persistent
symptoms.
In
summary,
our
findings
further
illustrate
multifaceted
nature
COVID
underscore
importance
understanding
factors
mechanisms
needed
effective
therapeutic
strategies
interventions.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(2), С. 170 - 170
Опубликована: Янв. 31, 2024
Postural
orthostatic
tachycardia
syndrome
(POTS)
is
a
common
accompaniment
of
variety
chronic,
inflammatory
diseases,
including
long
COVID,
as
are
small,
insoluble,
'fibrinaloid'
microclots.
We
here
develop
the
argument,
with
accompanying
evidence,
that
fibrinaloid
microclots,
through
their
ability
to
block
flow
blood
microcapillaries
and
thus
cause
tissue
hypoxia,
not
simply
correlated
but
in
fact,
by
preceding
it,
may
be
chief
intermediary
POTS,
which
body's
exaggerated
'physiological'
response
hypoxia.
Similar
reasoning
accounts
for
symptoms
bundled
under
term
'fatigue'.
Amyloids
known
membrane
disruptors,
when
targets
nerve
membranes,
this
can
explain
neurotoxicity
hence
autonomic
nervous
system
dysfunction
contributes
POTS.
Taken
together
view,
we
indicate
microclots
serve
link
POTS
fatigue
COVID
manner
at
once
both
mechanistic
explanatory.
This
has
clear
implications
treatment
such
diseases.
Current Problems in Cardiology,
Год журнала:
2024,
Номер
49(9), С. 102732 - 102732
Опубликована: Июль 1, 2024
Long-COVID-19
syndrome
(LCS)
exhibits
neurological
problems
such
as
peripheral
neuropathy
and
autonomic
nervous
system
(ANS)
dysfunction.
Exercise
intolerance
and,
consequently,
low
cardiorespiratory
fitness
(CRF)
are
some
of
the
most
common
symptoms
LCS.
We
describe
a
series
individuals
exhibiting
LCS
compared
to
control
group
posit
that
this
condition
may
be
related
exercise
capacity-mediated
disruption
ANS
resulting
particularly
in
intolerance.
Archives of Rehabilitation Research and Clinical Translation,
Год журнала:
2024,
Номер
6(4), С. 100366 - 100366
Опубликована: Авг. 19, 2024
Exercise
is
a
well-documented,
nonpharmacologic
treatment
for
individuals
with
autonomic
dysfunction
and
associated
orthostatic
intolerance,
such
as
postural
tachycardia
syndrome
related
disorders.
has
been
shown
to
increase
blood
volume,
reverse
cardiovascular
deconditioning,
improve
quality
of
life.
Current
first-line
standard
care
combines
graded
approaches
exercise
medications
lifestyle
modifications.
However,
current
rehabilitation
protocols
contain
rigid
timelines
progression
paradigms
that
often
threaten
tolerability
adherence.
In
addition,
they
fail
account
clinical
variables
potentially
critical
lack
guidance
individualization,
limiting
accessibility
patients
co-morbidities
affect
appropriateness
safety.
Therefore,
we
introduce
an
adaptive
approach
prescription
intolerance
allows
patient-specific
modifications
meet
functional
goals
wider
spectrum
patients,
thus
improving
The
proposed
integrates
iterative
physiological
symptomatic
assessments
provide
flexible,
yet
structured,
exposure
aerobic
strength
training
capacity
tolerance
daily
activities
BioMedical Engineering OnLine,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 3, 2025
Abstract
Background
Coronavirus
disease
19
(COVID-19)
patients
might
develop
sequelae
after
apparent
resolution
of
the
infection.
Autonomic
dysfunction
and
baroreflex
failure
have
been
frequently
reported.
However,
long-term
effect
COVID-19
on
cardiorespiratory
cardiovascular
neural
controls
has
not
investigated
with
directional
approaches
able
to
open
closed-loop
relationship
between
physiological
variables.
Methods
A
model-based
causal
spectral
approach,
namely
squared
coherence
(CK
2
),
was
applied
beat-to-beat
variability
series
heart
period
(HP)
systolic
arterial
pressure
(SAP),
respiratory
signal
(RESP)
acquired
at
rest
in
supine
position
during
active
standing
(STAND)
survivors
9
months
their
hospital
discharge.
Patients
were
categorized
according
need
ventilatory
support
hospitalization
as
individuals
that
had
no
continuous
positive
airway
(noCPAP,
n
=
27),
sub-intensive
care
unit
(CPAP,
14)
invasive
mechanical
ventilation
intensive
(IMV,
8).
Results
The
expected
decrease
strength
HP-RESP
dynamic
interactions
well
increase
dependence
HP
SAP
along
STAND
observed
this
result
held
regardless
severity
disease,
noCPAP,
CPAP
IMV
cohorts.
Regardless
experimental
condition,
causality
markers
did
vary
across
groups
either.
Conclusions
CK
markers,
association
an
orthostatic
challenge,
characterize
impairment
control
long
acute
infection
could
be
exploited
monitor
evolution
BMC Infectious Diseases,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 24, 2025
Long-term
COVID-19
(LC),
which
may
affect
the
autonomic
nervous
system
(ANS),
is
term
for
symptoms
that
some
patients
had
an
additional
month
after
contracting
virus.
Therefore,
during
LC
phase,
ANS
status
was
evaluated
in
with
mild-to-moderate
using
heart
rate
variability
(HRV),
a
measurement
of
function.
A
cross-sectional
research
173
participants
-
both
positive
and
negative
–
conducted.
Based
on
self-reports,
were
classified
as
to
whether
they
or
not.
5-minute
ECG
recorder
data
detection
response
report
used
measure
ANS.
There
notable
age
differences
across
groups
(p
=
0.034).
Patients
under
25
years
lower
HRV
categorized
very-low-frequency
(VLF)
domain
0.012).
Compared
group
without
LC,
higher
number
people
aberrant
neuroactivity
0.048).
Mild-to-moderate
young
middle
develop
dysfunction
one
infection.
Post-acute
sequelae
of
SARS-CoV-2
(PASC),
or
Long
COVID,
is
a
multi-system
disorder
often
involving
dysautonomia
and
pain,
linked
to
persistent
sympathetic
nervous
system
hyperactivity.
Dual
blocks
(DSBs),
including
stellate
ganglion
(SGBs),
are
minimally
invasive
procedures
that
may
recalibrate
dysregulated
signaling
alleviate
PASC
symptoms.
This
open-label,
non-randomized
pilot
study
included
20
participants
with
experiencing
pain
autonomic
Participants
received
right-sided
left-sided
SGB
one
week
apart.
Symptoms
were
assessed
at
baseline,
one,
four
using
the
Composite
Autonomic
Symptom
Score
(COMPASS-31)
Patient-Reported
Outcomes
Measurement
Information
System
(PROMIS-29)
scales.
Seventeen
completed
study,
demonstrating
significant
improvements
in
dysfunction
(38.4%
reduction
COMPASS-31
scores,
p
=
0.0016)
interference
(48.4%
reduction,
<
0.001)
by
four.
Improvements
sleep
quality
fatigue
also
(p
0.016
0.049,
respectively).
Overall,
88.2%
reported
symptom
relief,
no
adverse
events
observed.
DSBs
appear
be
promising
intervention
for
PASC-related
pain.
These
findings
warrant
further
investigation
larger,
randomized
controlled
trials
confirm
efficacy
explore
underlying
mechanisms.
