Опубликована: Янв. 1, 2024
Язык: Английский
Biomolecules, Год журнала: 2024, Номер 14(7), С. 835 - 835
Опубликована: Июль 11, 2024
Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.
Язык: Английский
Процитировано
11
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Июнь 26, 2024
Aging leads to physiological changes, including inflammaging-a chronic low-grade inflammatory state with significant implications for various systems, particularly cardiovascular health. Concurrently, immunosenescence-the age-related decline in immune function, exacerbates vulnerabilities pathologies older individuals. Examining the dynamic connections between immunosenescence, inflammation, and aging, this mini-review aims disentangle some of these interactions a better understanding their complex interplay. In context associated inflammaging compromises vascular integrity contributing atherosclerosis, endothelial dysfunction, arterial stiffening, hypertension. The aging system's amplifies oxidative stress, fostering an environment conducive atherosclerotic plaque formation. Noteworthy markers, such as high-sensitivity C-reactive protein, interleukin-6, interleukin-1β, interleukin-18, tumor necrosis factor-alpha emerge key players triggering signaling pathways intensifying immunosenescence. review we aim explore molecular cellular mechanisms underlying shedding light on nuanced contributions diseases. Furthermore, reciprocal relationship immunosenescence inflammaging, revealing self-reinforcing cycle that intensifies risks. This opens avenues potential therapeutic targets break mitigate dysfunction address Long COVID, introducing additional layer complexity Our stimulate continued exploration advance our within realm
Язык: Английский
Процитировано
7
Medicina, Год журнала: 2025, Номер 61(2), С. 333 - 333
Опубликована: Фев. 14, 2025
Background and Objectives: Cardiac involvement in COVID-19 has been confirmed during the acute stage of infection. However, prevalence spectrum post-infectious cardiac dysfunction remain incompletely clarified. The objective our study was to evaluate frequency echocardiographic changes 2 years after hospitalization for moderate severe patients with no previously known pathology. Material Methods: We conducted a retrospective cohort analyzing severity markers infection parameters assessed ≥2 illness, based on recent guideline recommended algorithm diagnostic left ventricular (LV) dysfunction. Results: included 50 Caucasian patients, 60% male, 54% aged < 65 years, 32% forms disease. primary comorbidities were hypertension, obesity, diabetes. correlated computed tomography (CT) lung lesion score neutrophil-to-lymphocyte ratio >6 but not associated post-COVID-19 changes. Left ejection fraction (LVEF) reduced only 18% cases, global longitudinal strain (GLS) impairment observed 46% contributing LV systolic subclinical 61%. Impaired diastolic disfunction normal pressure filling present 30.61% cases elevated 10.2%. Conclusions: is an independent predictive factor GLS impairment, which can indicate myocardial contractile dysfunction, even asymptomatic heart This underscores importance regular monitoring recovering from COVID-19.
Язык: Английский
Процитировано
0
Molecular & Cellular Proteomics, Год журнала: 2025, Номер unknown, С. 100929 - 100929
Опубликована: Фев. 1, 2025
Coronavirus infectious disease 19 (COVID-19) can lead to cardiac complications, yet the molecular mechanisms driving these effects remain unclear. Protein glycosylation is crucial for viral replication, immune response, and organ function has been found change in lungs liver of COVID-19 patients. However, how impacts protein not defined. Our study combined single nuclei transcriptomics, mass spectrometry (MS)-based glycomics, lectin-based tissue imaging investigate alterations N-glycosylation human heart post-COVID-19. We identified significant expression differences glycogenes involved N-glycan biosynthesis MS analysis revealed a reduction high mannose isomers paucimannose structures post-infection, with changes directly correlating independent comorbidities. observations suggest that primes tissues alter glycome at all levels, namely metabolism, nucleotide sugar transport, glycosyltransferase activity. Given role function, this provides basis understanding events leading damage post-COVID-19 informing future therapeutic strategies treat complications resulting from coronavirus infections.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер unknown, С. 114365 - 114365
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер unknown, С. 101507 - 101507
Опубликована: Март 1, 2025
Characterizing the paradigm and impact of long COVID is crucial for addressing this worldwide health challenge. This study aimed to investigate prevalence one year after primary Omicron infection characterize differences in long-term consequence between participants with persistent those who fully recovered. a community-based cross-sectional conducted from December 2023 March 2024 at China-Japan Friendship Hospital 16 administrative districts Beijing. 12,789 infected 2022 January were recruited through stratified multistage random sampling included final analysis. Of them, 376 229 without matched further physical examinations. The outcome was infection. Secondary outcomes muscle strength, exercise capacity, health-related quality life (HRQoL), mental health, work status, laboratory tests, Among (media [IQR] age, 48.4 [37.3 61.4] years; 7817 females [61.1%]), 995 them (7.8%) experienced within year, 651 (5.1%) having symptoms. Fatigue (598/995 [60.1%]) post-exertional malaise (367/995 [36.9%]) most common Brain fog had lowest resolution proportion as 4.2% year. odds increased reinfections (odds ratios reinfection 2.592 [95% CI: 2.188 3.061]; two or more: 6.171 [3.227 11.557]; all p < 0.001). Participants markedly lower strength (upper-limb: 26.9 ± 12.4 vs. 29.1 14.5 Kg; lower-limb: 40.0 [27.0 62.0] 43.0 [28.0 59.0] s), worse capacity poorer HRQoL, meaningful difference tests results compared COVID. They also exhibited significantly higher proportions abnormal lung function (FEV1 %pred<80%: 13.0% 2.0%; DLco 32.7% 19.9%) imaging abnormalities (23.5% 13.6%). considerable burden progression neurological symptoms following warrant close monitoring. Utilizing professional questionnaires developing reliable diagnostic tools are necessary improving diagnosis treatment supported by Beijing Research Center Respiratory Infectious Diseases (BJRID2024-012), Chinese Academy Medical Sciences Innovation Fund (2022-I2M-CoV19-005/CIFMS 2021-I2M-1-048), National Natural Science Foundation China (82241056/82200114/82200009), New Cornerstone Foundation.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 14, 2025
Background Clinical evidence suggests that pulmonary fibrosis (PF) and heart failure (HF) often co-exist; however, the specific impact of PF on HF remains underexplored. This gap in understanding complicates management treatment patients with PF. Objectives To investigate effects cardiac function myocardial using a mouse model evaluate therapeutic potential wogonin, flavonoid compound known for its anti-PF properties. Methods A was established via intratracheal administration bleomycin (BLM). Starting day 8 post-BLM treatment, wogonin (50 mg/kg) intraperitoneally administered every 2 days weeks. Cardiac assessed echocardiography, while evaluated through Masson staining. In vitro , H9C2 cardiomyocytes were exposed to CoCl or H O 24 h without (20 μM) treatment. Apoptosis DNA damage markers analysed immunofluorescence, immunoblotting, Comet assay. The interaction between Sirt1 examined biotin-affinity pulldown assays molecular docking simulations. Results Mice exhibited significant dysfunction fibrosis. Wogonin markedly improved ejection fraction attenuated mice. Mechanistic studies revealed alleviated cardiomyocyte apoptosis by upregulating downregulating γ-H2AX expression. Docking simulations predicted forms stable complex hydrogen-bonding hydrophobic interactions, which further validated assays. Conclusion exerts protective against mice modulating Sirt1/γ-H2AX-mediated pathways reduce apoptosis. These findings suggest as agent managing associated
Язык: Английский
Процитировано
0
Nano Energy, Год журнала: 2025, Номер unknown, С. 111039 - 111039
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Annals of Clinical Microbiology and Antimicrobials, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 20, 2025
Abstract Background Long COVID is a complex, heterogeneous syndrome affecting over four hundred million people globally. There are few recommendations, and no formal training exists for medical professionals to assist with clinical evaluation management of patients COVID. More research into the pathology, cellular, molecular mechanisms COVID, treatments needed. The goal this work disseminate essential information about recommendations definition, diagnosis, treatment, social issues physicians, researchers, policy makers address escalating global health crisis. Methods A 3-round modified Delphi consensus methodology was distributed internationally 179 healthcare professionals, persons lived experience in 28 countries. Statements were combined specific areas: research, society. Results survey resulted 187 comprehensive statements reaching strongest areas being diagnosis assessment, general research. We establish conditions different subgroups within umbrella. Clear reached that impacts COVID-19 infection on children should be priority, additionally need determine effects societies economies. it affects nervous system other organs not likely observed initial symptoms. note, biomarkers critically needed these issues. Conclusions This forms guidance spectrum as disease reinforces translational large-scale treatment trials protocols.
Язык: Английский
Процитировано
0
Опубликована: Май 2, 2024
Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID's burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.
Язык: Английский
Процитировано
3