Phytomedicine, Год журнала: 2024, Номер 135, С. 156118 - 156118
Опубликована: Окт. 11, 2024
Язык: Английский
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Ноя. 25, 2023
Gut microbiota plays a key role in insulin resistance (IR). Here we perform case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment P. improves IR, strengthens intestinal integrity, reduces systemic inflammation mice. We further demonstrate distasonis-derived nicotinic acid (NA) vital bioactive molecule fortifies barrier function via activating G-protein-coupled receptor 109a (GPR109a), leading to ameliorating also conduct dietary fiber screening induce growth. Dendrobium officinale polysaccharide (DOP) shows favorable growth-promoting effects on protects against IR mice simultaneously. Finally, the reduced NA levels were validated another human type 2 diabetes mellitus cohort. These findings reveal unique mechanisms provide viable strategies for treatment prevention by fiber.
Язык: Английский
Процитировано
57
Biochemical and Biophysical Research Communications, Год журнала: 2023, Номер 682, С. 1 - 20
Опубликована: Сен. 29, 2023
Язык: Английский
Процитировано
39
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Авг. 24, 2023
Background Studies showed that development of gut microbial dysbiosis has a close association with type 2 diabetes (T2D). It is not yet clear if there causal relationship between microbiota and T2D. Methods The data collected from the published genome-wide studies (GWASs) on T2D were analyzed. Two-sample Mendelian randomization (MR) analyses performed to identify bacterial taxa Significant further To confirm findings’ robustness, we sensitivity, heterogeneity, pleiotropy analyses. A reverse MR analysis was also check for potential causation. Results By combining findings all steps, identified six taxa, namely, Lachnoclostridium, Oscillospira, Roseburia, Ruminococcaceae UCG003, UCG010 Streptococcus . risk might be positively associated high relative abundance Roseburia but negatively UCG003 UCG010. results revealed relationships different genera And did reveal any evidence causality. Conclusion This study implied have anti-protective effect T2D, whereas Oscillospira , protective Our specific
Язык: Английский
Процитировано
24
Nutrients, Год журнала: 2024, Номер 16(2), С. 269 - 269
Опубликована: Янв. 16, 2024
Nutrition is one of the most influential environmental factors in both taxonomical shifts gut microbiota as well development type 2 diabetes mellitus (T2DM). Emerging evidence has shown that effects nutrition on these parameters not mutually exclusive and changes related metabolites such short-chain fatty acids (SCFAs) branched-chain amino (BCAAs) may influence systemic inflammation signaling pathways contribute to pathophysiological processes associated with T2DM. With this background, our review highlights macronutrients, carbohydrates, proteins, lipids, micronutrients, vitamins, minerals, T2DM, specifically through their alterations they produce. Additionally, we describe influences common food groups, which incorporate varying combinations macronutrients metabolic context mellitus. Overall, first line modifiable therapies management T2DM a better understanding mechanisms by its pathophysiology provides opportunities for optimizing dietary interventions.
Язык: Английский
Процитировано
11
Heliyon, Год журнала: 2024, Номер 10(4), С. e26377 - e26377
Опубликована: Фев. 1, 2024
Short-chain fatty acids (SCFAs) are thought to play a key role in the microbe-gut-brain axis and involve pathogenesis of variety neurological diseases. This study aimed identify research hotspots evolution trends SCFAs central nervous diseases (CNS) examine current trends.
Язык: Английский
Процитировано
9
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(23), С. 13083 - 13098
Опубликована: Июнь 3, 2024
Type 2 diabetes (T2DM) significantly diminishes people's quality of life and imposes a substantial economic burden. This pathological progression is intimately linked with specific gut microbiota, such as Akkermansia muciniphila. Pasteurized A. muciniphila (P-AKK) has been defined novel food by the European Food Safety Authority exhibited significant hypoglycemic activity. However, current research on activity P-AKK limited to metabolic level, neglecting systematic exploration at level. Consequently, its material basis mechanism action for hypoglycemia remain unclear. Drawing upon this foundation, we utilized high-temperature killed (H-K-AKK) insignificant control object. Assessments were conducted levels evaluate functions both H-K-AKK separately. Our study unveiled first time that ameliorated symptoms T2DM enhancing generation glucagon-Like Peptide 1 (GLP-1), pasteurized total proteins (PP) being pivotal component responsible Utilizing SDS-PAGE, proteomics, molecular docking techniques, deeply analyzed foundation PP. We scientifically screened identified protein weighing 77.85 kDa, designated P5. P5 enhanced GLP-1 synthesis secretion activating G protein-coupled receptor (GPCR) signaling pathway, free fatty acid (FFAR-2) target P5′s physiological These findings further promote widespread application in industry, laying solid theoretical utilization beneficial ingredient or functional component.
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 3, 2025
Indole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism treat obesity in mice. The experimental analyses focused on changes lipid distribution, inflammatory cytokines, glucose tolerance, microbiota composition, serum metabolomics of 60 C57BL/6N results demonstrated that reduced body weight, hepatic steatosis, systemic inflammation improved insulin resistance mice high-fat diet (HFD). Furthermore, remarkably enhanced enrichment probiotics Akkermansia Ligilactobacillus as well SCFA-producing bacteria (Eubacterium, Lactococcus, Coprococcus), while reducing abundance Eisenbergiella Rikenellaceae_RC9_gut_group. Also, notably up-regulated levels Claudin4, Occludin, ZO-1 proteins modulated argininosuccinic acid galactose. aforementioned findings suggest exerts significant anti-obesity effect by regulating abnormal microbiome, enhancing improving metabolic disorders.
Язык: Английский
Процитировано
1
BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 7, 2025
Type 2 diabetes mellitus (T2DM) is the fastest-growing metabolic disease in world. The gut microbiota linked to T2DM. Recent studies have showed that metabolism of can trigger Low dose radiation (LDR) has been proved activate various protective bioeffects on diabetes. However, underlying mechanisms remain unclear. In this study, T2DM model was established using high fat diet combined with streptozocin (STZ) injection C57BL/6 mice, and then exposed multiple 75 mGy LDR every other day for one month. changes blood glucose levels, body weight, damage pancreas were measured. addition, 16 S rDNA amplicon sequencing used detect alteration. Metabolic profiling carried out liquid mass spectrometry system, followed by combinative analysis Furthermore, inflammatory factors related pathways detected. We found attenuate levels weights reduce impairment. gut, regulated relative abundance Bacilli, Desulfobacterota, Verrucomicrobiota, Proteobacteria. non-target metabolomics significantly improve abnormalities T2DM, which closely abundance. effects activated TLR4/MyD88/NF-κB ameliorated LDR. These results suggest may exert a beneficial role modulating metabolites, especially pathway.
Язык: Английский
Процитировано
1
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Дек. 14, 2022
Diabetes mellitus (DM) is a global health threat. Searching for anti-diabetic components from natural resources of intense interest to scientists. Mushroom polysaccharides have received growing attention in anti-diabetes fields due their advantages broad resources, structure diversity, and multiple bioactivities, which are considered an unlimited source healthy active potentially applied functional foods nutraceuticals. In this review, the current knowledge about roles oxidative stress pathogenesis DM, extraction method mushroom polysaccharides, potential biological mechanisms associated with anti-diabetes, including antioxidant, hypolipidemic, anti-inflammatory, gut microbiota modulatory actions, were summarized based on variety
Язык: Английский
Процитировано
37
Pharmaceuticals, Год журнала: 2022, Номер 15(11), С. 1329 - 1329
Опубликована: Окт. 27, 2022
Plant polysaccharides (PPS) composed of more than 10 monosaccharides show high safety and various pharmacological activities, including immunoregulatory, antitumor, antioxidative, antiaging, other effects. In recent years, emerging evidence has indicated that many PPS are beneficial for metabolic diseases, such as cardiovascular disease (CVD), diabetes, obesity, neurological which usually caused by the disorder fat, sugar, protein. this review, we introduce common characteristics functional activity representative PPS, emphasize risks molecular mechanism discuss action obtained from plants Aloe vera, Angelica sinensis, pumpkin, Lycium barbarum, Ginseng, Schisandra chinensis, Dioscorea pposite, Poria cocos, tea in diseases. Finally, review will provide directions a reference future research development into potential drugs treatment
Язык: Английский
Процитировано
36