WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 21, 2025

Язык: Английский

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Protective Effects of White Kidney Bean (Phaseolus vulgaris L.) against Diet-Induced Hepatic Steatosis in Mice Are Linked to Modification of Gut Microbiota and Its Metabolites

Nutrients, Год журнала: 2023, Номер 15(13), С. 3033 - 3033

Опубликована: Июль 4, 2023

Disturbances in the gut microbiota and its derived metabolites are closely related to occurrence development of hepatic steatosis. The white kidney bean (WKB), as an excellent source protein, dietary fiber, phytochemicals, has recently received widespread attention might exhibit beneficial effects on a high-fat diet (HFD)-induced steatosis via targeting metabolites. results indicated that HFD, when supplemented with WKB for 12 weeks, could potently reduce obesity symptoms, serum lipid profiles, glucose, well improve insulin resistance liver function markers mice, thereby alleviating An integrated fecal microbiome metabolomics analysis further demonstrated was able normalize HFD-induced dysbiosis mediating alterations wide range Particularly, remarkably increased relative abundance probiotics (

Язык: Английский

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Gut Microbiota and Nutrition: Strategies for the Prevention and Treatment of Type 2 Diabetes

Journal of Medicinal Food, Год журнала: 2024, Номер 27(2), С. 97 - 109

Опубликована: Фев. 1, 2024

The prevalence of diabetes has increased in last decades worldwide and is expected to continue do so the coming years, reaching alarming figures. Evidence have shown that patients with type 2 (T2D) intestinal microbial dysbiosis. Moreover, several mechanisms link microbiota appearance insulin resistance diabetes. Diet a crucial factor related changes composition, diversity, activity gut (GM). In this review, current future possibilities nutrient–GM interactions as strategy alleviate T2D are discussed, well decreased low-grade inflammation resistance. A bibliographic search clinical trials Pubmed, Web Science, Scopus was carried out, using terms "gut microbiota, diet diabetes." data analyzed review support idea dietary interventions targeting including use prebiotics probiotics, can improve glycemic parameters. However, these strategies should be individualized taking into account other internal external factors. Advances understanding role development metabolic diseases such T2D, its translation therapeutic approach for management diabetes, necessary allow comprehensive approach.

Язык: Английский

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Alterations of the gut microbiota and metabolites by ShenZhu TiaoPi granule alleviates hyperglycemia in GK rats

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Авг. 29, 2024

ShenZhu TiaoPi granule (STG) is a compound prescription that used in Chinese medicine for the treatment of type 2 diabetes mellitus (T2DM). Previous studies have indicated hypoglycaemic effect, but underlying mechanism remains unclear. Goto-Kakizaki (GK) rats were to establish an vivo T2DM model (Mod). The metformin (Met) and STG time was 12 weeks. Fasting blood glucose (FBG) insulin levels area under curve (GAUC) measured. Intestinal pathology permeability observed. Microbial diversity analysis metabolomics investigate mechanisms. Compared with Con group, Mod group presented significant differences weight, FBG, GAUC, homeostasis assessment–insulin resistance (HOMA-IR) indices ( p < 0.01). Met improved these indicators pathological morphology zonula occludens 1 protein intestines altered, leading increases lipopolysaccharide (LPS) interleukin-1β (IL-1β) levels. In groups, intestinal conditions improved, LPS IL-1β significantly decreased Changes gut microbiota metabolites occurred group. abundance Intestinimonas increased, Eubacterium coprostanoligenes 0.05). Moreover, also altered 2-deoxyglucose, beta-muricholic acid dioxolithocholic production. addition, main metabolic pathways affected by bile biosynthesis cholesterol metabolism. Intestinimonas, D-maltose_and_alpha-lactose may be potential biomarkers effects STG. alleviates hyperglycaemia via GK rats.

Язык: Английский

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Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 3, 2024

Abstract White kidney bean ( Phaseolus vulgaris L.) extracts can aid weight management by reducing calorie intake from complex carbohydrates through alpha-amylase inhibition. We examined the impact of a proprietary aqueous extract whole dried white beans standardized its inhibitor activity (Phase 2 (WKBE)) on in subjects with overweight and moderate obesity. In randomized, double-blind, placebo-controlled fashion, 81 participants completed study ingested either high dose Phase (1000 mg, WKBE HIGH), low (700 LOW), or matching placebo (microcrystalline cellulose, PLA) three times day, 30 min before meals, for 12 weeks during restricted diet. dose-dependent manner, significantly reduced body weight, fat mass, BMI, waist, hip HIGH group thigh circumference. is an effective safe supplement aiding loss. ClinicalTrials.gov identifier NCT02930668.

Язык: Английский

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Phytochemical Contents and Bioactive Compounds in Widely Consumed Cereals, Legumes, and Vegetables in Abruzzo Region, Italy: A Critical Review

Food Safety and Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet, dietary model that has been shown to have fundamental role prevention chronic diseases benefits for consumer's health. This review aims collect, describe, identify vegetables mostly consumed (Italy) from 2020 till now, pointing attention their biological effects nutritional value. review, we collected research works previously reported literature now using common online tools such as PubMed Google Scholar by keywords most cited papers, providing general overview topic, clinical trials, scientific studies conducted on described matrices region. Some Abruzzo's nationally recognized traditional appear list (PAT) are also Slow Food Presidia. international association supports producers who preserve gastronomic traditions safeguard biodiversity ecological production methods. Several indicate biologically active compounds phytochemicals found commonly offer beneficial treatment metabolic diseases.

Язык: Английский

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The Link between Gut Microbiome, Nutraceuticals, Diet, and Diabetes Mellitus: A Bibliometric and Visual Analysis of Research and Emerging Trends from 2012 to 2022

Опубликована: Янв. 2, 2024

The increasing prevalence of diabetes mellitus (DM) worldwide is a cause for global concern. Recent evidence suggests that the interaction between one’s diet and gut microbiome are key modifiers diabetes, highlighting potential role microbiome-modulating nutraceuticals. This bibliometric analysis examines literature published 2012 2022 to explore trends in latest research, with additional discussion on major takeaways future directions. We selected analyzed 640 articles from an initial pool 4,099 Web Science using Microsoft Excel 2016 VOSviewer software (version 1.6.19). Our exploration covered most common journals, countries, study designs, experimental subjects, types DM, organisms nutraceuticals studied, cited articles. also evaluated publications terms organizations, along collaborative networks among authors, organizations co-occurrence author keywords selection. It evident number each year this field has attracted growing attention over last decade. Nonetheless, continued research essential sustain trend. overarching marks steady progress understanding of—and potentially discovering applications of—microbiome modulation enhance metabolic pathways health outcomes. Advancements may lead therapeutic specific diets modulate microbiota DM.

Язык: Английский

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The link between gut microbiome, nutraceuticals, diet, and diabetes mellitus: a bibliometric and visual analysis of research and emerging trends from 2012 to 2022

Deleted Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Сен. 27, 2024

Abstract Purpose The increasing prevalence of diabetes mellitus (DM) worldwide is a cause for global concern. Recent evidence suggests that the interaction between one’s diet and gut microbiome are key modifiers diabetes, highlighting potential role microbiome-modulating nutraceuticals. This bibliometric analysis examines literature published 2012 2022 to explore trends in latest research, with additional discussion on major takeaways future directions. Methods We selected analyzed 640 articles from an initial pool 4,099 Web Science using Microsoft Excel 2016 VOSviewer software (version 1.6.19). Results Our exploration uncovered most commonly associated influential journals, countries, study designs, experimental subjects, types DM, organisms nutraceuticals studied, cited articles. also noted publications across organizations, along collaborative networks among authors, organizations co-occurrence author keywords selection. Conclusion It evident number each year this field has attracted growing attention over last decade. Nonetheless, continued research essential sustain trend. overarching marks steady progress understanding role—and potentially discovering applications—microbiome modulation enhance metabolic pathways health outcomes. Advancements may lead therapeutic applications specific diets modulate microbiota DM.

Язык: Английский

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Impact of Gut Microbiome Interventions on Glucose and Lipid Metabolism in Metabolic Diseases: A Systematic Review and Meta-Analysis

Life, Год журнала: 2024, Номер 14(11), С. 1485 - 1485

Опубликована: Ноя. 14, 2024

Background: The gut microbiome is increasingly recognized as a key player in metabolic health, influencing glucose and lipid metabolism through various mechanisms. However, the efficacy of microbiota-targeted interventions, such probiotics, prebiotics, fecal microbiota transplantation (FMT), diet-based treatments, remains unclear for specific outcomes. In this study, aim was to evaluate impact these interventions on parameters individuals with diseases diabetes mellitus (DM), obesity, syndrome. Methods: This systematic review meta-analysis included 41 randomized controlled trials that investigated effects treatments fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), triglycerides. A comprehensive search conducted using databases like PubMed, Google Scholar, Scopus, focusing targeting microbiota. performed random-effects models, effect sizes calculated each outcome. Risk bias assessed Cochrane Bias tool. Results: Gut significantly reduced HbA1c, HOMA-IR, LDL-C, triglycerides, moderate heterogeneity observed across studies. also led modest increases HDL-C levels. Probiotic synbiotic showed most consistent benefits improving both profiles, while FMT yielded mixed results. Short-term rapid microbial shifts but less pronounced improvements, whereas longer-term had more substantial benefits. Conclusions: it demonstrated can improve outcomes, offering potential therapeutic strategy managing diseases. effectiveness varies depending type, duration, population characteristics, highlighting need further long-term studies assess sustained modulation health.

Язык: Английский

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White kidney bean extract as a nutraceutical: effects on gut microbiota, alpha-amylase inhibition, and user experiences

Gut Microbiome, Год журнала: 2023, Номер 4

Опубликована: Янв. 1, 2023

White kidney bean extract (WKBE) is a nutraceutical often advocated as an anti-obesity agent. The main proposed mechanism for these effects alpha-amylase inhibition, thereby slowing carbohydrate digestion and absorption. Thus, it possible that WKBE could impact the gut microbiota modulate health. We investigated of supplementing 20 healthy adults with 1 week in randomised, placebo-controlled crossover trial on composition microbiota, gastrointestinal (GI) inflammation (faecal calprotectin), GI symptoms, stool habits. conducted

Язык: Английский

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