Italy
represents
a
territory
rich
of
common
bean
landraces,
most
them
still
uncharacterized.
Thus,
here,
the
proximal
composition
and
metabolic
profiles
(fatty
acid
composition,
total
free
amino
acids)
as
well
polyphenols
antioxidant
capacities
both
‘Cerato’
‘Curniciello’
dry
beans,
cultivated
in
Caserta’s
rural
areas
(Southern
Italy)
were
evaluated,
comparison
with
other
local
known
beans.
The
average
vintages
values
exhibit
lower
content
crude
proteins
(21.18
vs
23.41
g/100
g),
lipids
(1.27
2.08
acids
(16.01
vs.
17.89
g)
respect
to
although
slight
statistical
differences
found
between
two
different
harvest
years
analysed
(2020-2021).
Two
essential
fatty
(n-6
linoleic
n-3
alpha-linolenic)
oleic
abundant
(~90%
total).
Subsequently,
trypsin
chymotrypsin
inhibitory
activities
without
beans
boiling
treatment
(2
h)
α-amylase
α-glucosidase
investigated,
considering
their
capability
decrease
protein
carbohydrates
intake
assimilation.
In
addition,
AFLP
analysis
landraces
exhibits
polymorphic
patterns
useful
for
authentication
traceability.Overall,
these
data
represent
starting
point
promote
cultivation
consumption
contributing
preserve
culinary
traditions
Italian
biodiversity.
Nutrients,
Год журнала:
2023,
Номер
15(13), С. 3033 - 3033
Опубликована: Июль 4, 2023
Disturbances
in
the
gut
microbiota
and
its
derived
metabolites
are
closely
related
to
occurrence
development
of
hepatic
steatosis.
The
white
kidney
bean
(WKB),
as
an
excellent
source
protein,
dietary
fiber,
phytochemicals,
has
recently
received
widespread
attention
might
exhibit
beneficial
effects
on
a
high-fat
diet
(HFD)-induced
steatosis
via
targeting
metabolites.
results
indicated
that
HFD,
when
supplemented
with
WKB
for
12
weeks,
could
potently
reduce
obesity
symptoms,
serum
lipid
profiles,
glucose,
well
improve
insulin
resistance
liver
function
markers
mice,
thereby
alleviating
An
integrated
fecal
microbiome
metabolomics
analysis
further
demonstrated
was
able
normalize
HFD-induced
dysbiosis
mediating
alterations
wide
range
Particularly,
remarkably
increased
relative
abundance
probiotics
(
Journal of Medicinal Food,
Год журнала:
2024,
Номер
27(2), С. 97 - 109
Опубликована: Фев. 1, 2024
The
prevalence
of
diabetes
has
increased
in
last
decades
worldwide
and
is
expected
to
continue
do
so
the
coming
years,
reaching
alarming
figures.
Evidence
have
shown
that
patients
with
type
2
(T2D)
intestinal
microbial
dysbiosis.
Moreover,
several
mechanisms
link
microbiota
appearance
insulin
resistance
diabetes.
Diet
a
crucial
factor
related
changes
composition,
diversity,
activity
gut
(GM).
In
this
review,
current
future
possibilities
nutrient–GM
interactions
as
strategy
alleviate
T2D
are
discussed,
well
decreased
low-grade
inflammation
resistance.
A
bibliographic
search
clinical
trials
Pubmed,
Web
Science,
Scopus
was
carried
out,
using
terms
"gut
microbiota,
diet
diabetes."
data
analyzed
review
support
idea
dietary
interventions
targeting
including
use
prebiotics
probiotics,
can
improve
glycemic
parameters.
However,
these
strategies
should
be
individualized
taking
into
account
other
internal
external
factors.
Advances
understanding
role
development
metabolic
diseases
such
T2D,
its
translation
therapeutic
approach
for
management
diabetes,
necessary
allow
comprehensive
approach.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 29, 2024
ShenZhu
TiaoPi
granule
(STG)
is
a
compound
prescription
that
used
in
Chinese
medicine
for
the
treatment
of
type
2
diabetes
mellitus
(T2DM).
Previous
studies
have
indicated
hypoglycaemic
effect,
but
underlying
mechanism
remains
unclear.
Goto-Kakizaki
(GK)
rats
were
to
establish
an
vivo
T2DM
model
(Mod).
The
metformin
(Met)
and
STG
time
was
12
weeks.
Fasting
blood
glucose
(FBG)
insulin
levels
area
under
curve
(GAUC)
measured.
Intestinal
pathology
permeability
observed.
Microbial
diversity
analysis
metabolomics
investigate
mechanisms.
Compared
with
Con
group,
Mod
group
presented
significant
differences
weight,
FBG,
GAUC,
homeostasis
assessment–insulin
resistance
(HOMA-IR)
indices
(
p
<
0.01).
Met
improved
these
indicators
pathological
morphology
zonula
occludens
1
protein
intestines
altered,
leading
increases
lipopolysaccharide
(LPS)
interleukin-1β
(IL-1β)
levels.
In
groups,
intestinal
conditions
improved,
LPS
IL-1β
significantly
decreased
Changes
gut
microbiota
metabolites
occurred
group.
abundance
Intestinimonas
increased,
Eubacterium
coprostanoligenes
0.05).
Moreover,
also
altered
2-deoxyglucose,
beta-muricholic
acid
dioxolithocholic
production.
addition,
main
metabolic
pathways
affected
by
bile
biosynthesis
cholesterol
metabolism.
Intestinimonas,
D-maltose_and_alpha-lactose
may
be
potential
biomarkers
effects
STG.
alleviates
hyperglycaemia
via
GK
rats.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 3, 2024
Abstract
White
kidney
bean
(
Phaseolus
vulgaris
L.)
extracts
can
aid
weight
management
by
reducing
calorie
intake
from
complex
carbohydrates
through
alpha-amylase
inhibition.
We
examined
the
impact
of
a
proprietary
aqueous
extract
whole
dried
white
beans
standardized
its
inhibitor
activity
(Phase
2
(WKBE))
on
in
subjects
with
overweight
and
moderate
obesity.
In
randomized,
double-blind,
placebo-controlled
fashion,
81
participants
completed
study
ingested
either
high
dose
Phase
(1000
mg,
WKBE
HIGH),
low
(700
LOW),
or
matching
placebo
(microcrystalline
cellulose,
PLA)
three
times
day,
30
min
before
meals,
for
12
weeks
during
restricted
diet.
dose-dependent
manner,
significantly
reduced
body
weight,
fat
mass,
BMI,
waist,
hip
HIGH
group
thigh
circumference.
is
an
effective
safe
supplement
aiding
loss.
ClinicalTrials.gov
identifier
NCT02930668.
Food Safety and Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
ABSTRACT
The
Abruzzo
region
boasts
a
wide
range
of
typical
food
products
including
cereals,
legumes,
and
vegetables.
In
this
context,
they
take
part
in
the
Mediterranean
diet,
dietary
model
that
has
been
shown
to
have
fundamental
role
prevention
chronic
diseases
benefits
for
consumer's
health.
This
review
aims
collect,
describe,
identify
vegetables
mostly
consumed
(Italy)
from
2020
till
now,
pointing
attention
their
biological
effects
nutritional
value.
review,
we
collected
research
works
previously
reported
literature
now
using
common
online
tools
such
as
PubMed
Google
Scholar
by
keywords
most
cited
papers,
providing
general
overview
topic,
clinical
trials,
scientific
studies
conducted
on
described
matrices
region.
Some
Abruzzo's
nationally
recognized
traditional
appear
list
(PAT)
are
also
Slow
Food
Presidia.
international
association
supports
producers
who
preserve
gastronomic
traditions
safeguard
biodiversity
ecological
production
methods.
Several
indicate
biologically
active
compounds
phytochemicals
found
commonly
offer
beneficial
treatment
metabolic
diseases.
The
increasing
prevalence
of
diabetes
mellitus
(DM)
worldwide
is
a
cause
for
global
concern.
Recent
evidence
suggests
that
the
interaction
between
one’s
diet
and
gut
microbiome
are
key
modifiers
diabetes,
highlighting
potential
role
microbiome-modulating
nutraceuticals.
This
bibliometric
analysis
examines
literature
published
2012
2022
to
explore
trends
in
latest
research,
with
additional
discussion
on
major
takeaways
future
directions.
We
selected
analyzed
640
articles
from
an
initial
pool
4,099
Web
Science
using
Microsoft
Excel
2016
VOSviewer
software
(version
1.6.19).
Our
exploration
covered
most
common
journals,
countries,
study
designs,
experimental
subjects,
types
DM,
organisms
nutraceuticals
studied,
cited
articles.
also
evaluated
publications
terms
organizations,
along
collaborative
networks
among
authors,
organizations
co-occurrence
author
keywords
selection.
It
evident
number
each
year
this
field
has
attracted
growing
attention
over
last
decade.
Nonetheless,
continued
research
essential
sustain
trend.
overarching
marks
steady
progress
understanding
of—and
potentially
discovering
applications
of—microbiome
modulation
enhance
metabolic
pathways
health
outcomes.
Advancements
may
lead
therapeutic
specific
diets
modulate
microbiota
DM.
Abstract
Purpose
The
increasing
prevalence
of
diabetes
mellitus
(DM)
worldwide
is
a
cause
for
global
concern.
Recent
evidence
suggests
that
the
interaction
between
one’s
diet
and
gut
microbiome
are
key
modifiers
diabetes,
highlighting
potential
role
microbiome-modulating
nutraceuticals.
This
bibliometric
analysis
examines
literature
published
2012
2022
to
explore
trends
in
latest
research,
with
additional
discussion
on
major
takeaways
future
directions.
Methods
We
selected
analyzed
640
articles
from
an
initial
pool
4,099
Web
Science
using
Microsoft
Excel
2016
VOSviewer
software
(version
1.6.19).
Results
Our
exploration
uncovered
most
commonly
associated
influential
journals,
countries,
study
designs,
experimental
subjects,
types
DM,
organisms
nutraceuticals
studied,
cited
articles.
also
noted
publications
across
organizations,
along
collaborative
networks
among
authors,
organizations
co-occurrence
author
keywords
selection.
Conclusion
It
evident
number
each
year
this
field
has
attracted
growing
attention
over
last
decade.
Nonetheless,
continued
research
essential
sustain
trend.
overarching
marks
steady
progress
understanding
role—and
potentially
discovering
applications—microbiome
modulation
enhance
metabolic
pathways
health
outcomes.
Advancements
may
lead
therapeutic
applications
specific
diets
modulate
microbiota
DM.
Life,
Год журнала:
2024,
Номер
14(11), С. 1485 - 1485
Опубликована: Ноя. 14, 2024
Background:
The
gut
microbiome
is
increasingly
recognized
as
a
key
player
in
metabolic
health,
influencing
glucose
and
lipid
metabolism
through
various
mechanisms.
However,
the
efficacy
of
microbiota-targeted
interventions,
such
probiotics,
prebiotics,
fecal
microbiota
transplantation
(FMT),
diet-based
treatments,
remains
unclear
for
specific
outcomes.
In
this
study,
aim
was
to
evaluate
impact
these
interventions
on
parameters
individuals
with
diseases
diabetes
mellitus
(DM),
obesity,
syndrome.
Methods:
This
systematic
review
meta-analysis
included
41
randomized
controlled
trials
that
investigated
effects
treatments
fasting
glucose,
glycated
hemoglobin
(HbA1c),
homeostatic
model
assessment
insulin
resistance
(HOMA-IR),
total
cholesterol,
low-density
lipoprotein
cholesterol
(LDL-C),
high-density
(HDL-C),
triglycerides.
A
comprehensive
search
conducted
using
databases
like
PubMed,
Google
Scholar,
Scopus,
focusing
targeting
microbiota.
performed
random-effects
models,
effect
sizes
calculated
each
outcome.
Risk
bias
assessed
Cochrane
Bias
tool.
Results:
Gut
significantly
reduced
HbA1c,
HOMA-IR,
LDL-C,
triglycerides,
moderate
heterogeneity
observed
across
studies.
also
led
modest
increases
HDL-C
levels.
Probiotic
synbiotic
showed
most
consistent
benefits
improving
both
profiles,
while
FMT
yielded
mixed
results.
Short-term
rapid
microbial
shifts
but
less
pronounced
improvements,
whereas
longer-term
had
more
substantial
benefits.
Conclusions:
it
demonstrated
can
improve
outcomes,
offering
potential
therapeutic
strategy
managing
diseases.
effectiveness
varies
depending
type,
duration,
population
characteristics,
highlighting
need
further
long-term
studies
assess
sustained
modulation
health.
White
kidney
bean
extract
(WKBE)
is
a
nutraceutical
often
advocated
as
an
anti-obesity
agent.
The
main
proposed
mechanism
for
these
effects
alpha-amylase
inhibition,
thereby
slowing
carbohydrate
digestion
and
absorption.
Thus,
it
possible
that
WKBE
could
impact
the
gut
microbiota
modulate
health.
We
investigated
of
supplementing
20
healthy
adults
with
1
week
in
randomised,
placebo-controlled
crossover
trial
on
composition
microbiota,
gastrointestinal
(GI)
inflammation
(faecal
calprotectin),
GI
symptoms,
stool
habits.
conducted