Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence

Reproductive BioMedicine Online, Год журнала: 2024, Номер 49(6), С. 104381 - 104381

Опубликована: Июль 20, 2024

Язык: Английский

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Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation

Gastrointestinal Disorders, Год журнала: 2024, Номер 6(4), С. 801 - 815

Опубликована: Сен. 27, 2024

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These involve production of metabolites, signaling molecules, and direct communication cells, which modulate hormone secretion activity. As result, can exert neuroendocrine effects contribute to metabolic regulation, adiposity, appetite control. Additionally, influences reproductive altering levels sex hormones such as estrogen testosterone, potentially contributing conditions like polycystic ovary syndrome (PCOS) hypogonadism. Given these roles, targeting offers researchers clinicians novel opportunities improve overall well-being. Probiotics,

Язык: Английский

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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 19, 2025

This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. utilized genome-wide association (GWAS) summary statistics encompassing 179 lipidomes six prevalent FRDs, namely polycystic ovary syndrome (PCOS), endometriosis, uterine fibroid, infertility, endometrial cancer, ovarian cancer. The two-sample MR (TSMR) approach was employed investigate relationships, with further validation false discovery rate (FDR) multivariable (MVMR) Subsequently, a range comprehensive evaluations were performed, including sensitivity analysis, mediation reverse steiger test. Examining traits as exposures 6 FRDs outcomes, this identified significant effects 56 lipids on FRDs. Following multiple testing correction MVMR validation, sphingomyelin (d38:2) found have protective effect against PCOS (β = -0.104, 95% CI: -0.199 ~ -0.010, P 0.031). Phosphatidylcholine (18:0_22:6) associated decreased risk developing fibroid -0.111, -0.201~ -0.021, 0.016), sterol ester (27:1/20:3) showed significance in cancer -0.248, -0.443 -0.053, 0.013). Conversely, phosphatidylethanolamine (18:2_0:0) increased endometriosis 0.183, 0.015 0.350, 0.033), while (27:1/18:1) posed influence 1.007, 0.925 1.089, < 0.001), phosphatidylcholine (16:0_22:6) 0.229, 0.039 0.420, 0.018). Furthermore, it determined that associations these profiles independent BMI, obesity, diabetes, smoking, alcohol use, physical activity, inflammation, depression, waist-hip ratio, vitamin D, dehydroepiandrosterone sulphate, sex hormone binding globulin, testosterone levels. Most outcomes passed consistent tests without evidence heterogeneity, pleiotropy, or causality. results indicated close specific lipidomes, particularly sphingomyelin, lysophosphatidylethanolamine, cholesterol ester, phosphatidylcholines, These lipid species may potentially serve biomarkers future drug targets for treatment

Язык: Английский

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Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 7, 2025

We developed a prediction model for postprandial glycemic response (PPGR) in pregnant women, including those with diet-treated gestational diabetes mellitus (GDM) and healthy explored the role of gut microbiota improving accuracy. The study involved 105 women (77 GDM, 28 healthy), who underwent continuous glucose monitoring (CGM) 7 days, provided food diaries, gave stool samples microbiome analysis. Machine learning models were created using CGM data, meal content, lifestyle factors, biochemical parameters, data (16S rRNA gene sequence analysis). Adding increased explained variance peak levels (GLUmax) from 34 to 42% incremental area under curve (iAUC120) 50 52%. final showed better correlation measured PPGRs than one based only on carbohydrate count (r = 0.72 vs. r 0.51 iAUC120). Although features important, their contribution performance was modest.

Язык: Английский

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Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 22, 2025

Previous studies suggested that immune factors may play critical roles in female infertility, but their causal links remain unclear. To address this gap, study employs the Mendelian randomization (MR) to delineate association between circulating and infertility. This employed summary-level data from three genome-wide (GWAS) encompassing 731 peripheral cell signatures, 41 cytokines, five infertility phenotypes reveal relationship Causalities of exposure-outcome pairs were explored mainly using two-sample MR, comprehensive sensitivity analyses deployed validate reliability results. Multi-variable (MVMR) was further examine potential mediating effects significant exposures. Following false discovery rate (FDR) correction analyses, univariable identified distinct signatures across subtypes. Peripheral levels Naive CD8br %CD8br, MIP1B IL17 causally associated with general higher level decreased risk ovarian Furthermore, CD80 on monocyte a tubal features (CD86 + myeloid DC AC, HLA DR NK %NK, CD16 CD14- monocyte) for uterine factor cytokines (MIP1B, IL18, IL17) genetic causes cervical vaginal other or unspecified origin (FIOTHNAS). MVMR revealed MIP1B's FIOTHNAS substantially attenuated upon adjusting IL18. Our results highlight response contributes through subtype-specific mechanisms, providing clues following clinical research treatment.

Язык: Английский

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Gut microbiota and male fertility: A two-sample Mendelian randomization study

Medicine, Год журнала: 2025, Номер 104(8), С. e41542 - e41542

Опубликована: Фев. 21, 2025

Previous studies have reported that alterations in gut microbiota composition are associated with male fertility. However, it is unclear and difficult to establish whether these associations reflect a causal relationship. We assessed genome-wide association study summary statistics for fertility perform MR analysis. Independent single nucleotide polymorphisms closely 211 bacterial taxa (N = 122,110) were identified as instrumental variables. The statistic data infertility 733,479), abnormal spermatozoa 209,921) erectile dysfunction 223,805) obtained from the latest release FinnGen consortium outcome of interest. Two-sample was performed evaluate effect on fertility, including inverse-variance-weighted (IVW) method, weighted median MR-Egger, mode-based estimation MR-PRESSO. A series sensitivity analyses validate robustness results. tested by Cochran’s Q test, MR-Egger intercept analysis, leave-one-out analysis funnel plot used assess association. Combining results discovery replication stages, we 3 genus. Ruminiclostridm6 (OR 0.537, 95%CI 0.292–0.987, P .045, PFDR 0.234) found be infertility, decrease its quantity increased risk infertility. Decreased Prevotella9 0.670, 95% CI 0.452–0.992, .046, 0.175) related sperm. Lachnospiraceae NC2004 group 1.173, 1.008–1.366, .078, 0.530) dysfunction, there positive correlation between them. No heterogeneity pleiotropy detected. This implied relationship genus, genus thus providing novel insights into microbiota-mediated development mechanism ADs. Nevertheless, future warranted dissect underlying mechanisms specific taxa’s role pathophysiology

Язык: Английский

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Causal relationships between gut microbiota and male reproductive inflammation and infertility: Insights from Mendelian randomization

Medicine, Год журнала: 2025, Номер 104(17), С. e42323 - e42323

Опубликована: Апрель 25, 2025

The study observed interactions between gut microbiota and male reproductive health, noting that the causal relationships were previously unclear. It aimed to explore potential cause-and-effect relationship bacteria problems such as inflammation, infertility, sperm functionality, using a two-sample Mendelian randomization method examine these connections. analysis found certain bacterial genera, Erysipelatoclostridium (0.71 [0.55–0.92]), Parasutterella (0.74 [0.57–0.96]), Ruminococcaceae UCG-009 (0.77 [0.60–0.98]), Slackia (0.69 [0.49–0.96]), showed protective effects against prostatitis. In contrast, other genera like Faecalibacterium (1.59 [1.08–2.34]), Lachnospiraceae UCG004 (1.64 [1.15–2.34]), Odoribacter (1.68 [1.01–2.81]), Paraprevotella (1.28 [1.03–1.60]), Sutterella (1.58 [1.13–2.19]) detrimental. Additionally, identified 2 orchitis epididymitis, 3 5 abnormal spermatozoa. Further of sperm-related proteins revealed associations specific SPACA3, SPACA7, SPAG11A, SPAG11B, SPATA9, SPATA20, ZPBP4. results remained robust after sensitivity reverse analysis. concluded have roles in sperm-associated proteins. This provides novel strategy for early diagnosis identification therapeutic targets inflammation infertility.

Язык: Английский

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Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Июль 4, 2024

Background Although numerous studies have illustrated the connection between gut microbiota and endometriosis, a conspicuous gap exists in research focusing on pathogenesis of endometriosis at various sites its linkage with infertility. Methods In this study, we used two-sample Mendelian randomization analysis to investigate effect development different regions, including uterus, ovary, fallopian tube, pelvic peritoneum, vagina, rectovaginal septum, as well intestine. Additionally, explored correlation endometriosis-induced Genetic associations microbes were obtained from genome-wide association study (GWAS) datasets provided by MiBioGen consortium, whereas endometriosis-related GWAS data sourced FinnGen dataset. our analysis, single-nucleotide polymorphisms instrumental variables, primary estimation causal performed via inverse variance weighting method. Our sensitivity analyses incorporated heterogeneity tests, pleiotropy leave-one-out Results We identified genus level four bacterial communities endometriosis. Subsequently, several subtypes anatomical recognized. Specifically, three genera linked ovarian six associated tubal showed links peritoneum five connected vaginal septum seven demonstrated linkages intestinal one was adenomyosis, exhibited Conclusion elucidates site-specific thereby augmenting understanding pathophysiology Moreover, findings pave way for potential therapeutic strategies targeting individuals grappling

Язык: Английский

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The modern pathogenetic challenges of polycystic ovary syndrome

Reproductive health of woman, Год журнала: 2024, Номер 2, С. 75 - 80

Опубликована: Март 9, 2024

Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women reproductive age. In pathogenesis its development a great importance paid to hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS accompanied by infertility, cardiovascular risks, mellitus.The article devoted review modern scientific literature about last researches mechanisms disorders which are connected with also, psychological disturbance stress. The describes specific conditions patients. On basis analyzed publications connection between disorders, overweight, obesity lipidogram parameters presented.Also, gut vaginal microbiota described this paper. studies demonstrate significant changes human microbiome course polycystic syndrome. presents concepts difference composition vagina syndrome.The pathogenetic role processes pathogenesis, namely, regulation immune response inflammation pathology, described. It has been shown that there differences microflora intestines, manifested decreased concentration Lactobacillus presence variety other microorganisms compared healthy women.Thus, main links closely each other. That why multimodal approaches for study management patients extremely important.

Язык: Английский

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The causality between gut microbiota and endometriosis: a bidirectional Mendelian randomization study

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 22, 2024

Observational studies and animal experiments had suggested a potential relationship between gut microbiota abundance pathogenesis of endometriosis (EMs), but the relevance this remains to be clarified.

Язык: Английский

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