Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms

Reproductive Toxicology, Год журнала: 2025, Номер unknown, С. 108909 - 108909

Опубликована: Апрель 1, 2025

Язык: Английский

---

Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while Diethyl-hexyl terephthalate up-regulates their expression including SOD-1

Xenobiotica, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Апрель 16, 2025

Phthalates, widely utilized as plasticisers to enhance the flexibility of rigid materials like polyvinyl chloride, are known for their endocrine-disrupting properties and cytotoxic effects. This study investigated impact Diisononyl phthalate (DINP) Diethyl-hexyl terephthalate (DEHT) on human endothelial cells (EA.hy926). The assessment focused cell viability, reactive oxygen species (ROS) production, antioxidant-responsive genes expression (NFE2L2, SOD1, TXN, TXNRD2) following exposure varying 1, 10, 100 µg/mL DINP or DEHT. Cell viability was determined using MTT lactate dehydrogenase (LDH) release assays. ROS were measured DCFDA assay. Gene analysis conducted via qRT-PCR after 48 h exposure. Results revealed that significantly reduced at 11 17% 72 h, respectively; whereas increased LDH by 69% 48h. levels also rose 19-30%, accompanied down-regulation NFE2L2, TXNRD2. Conversely, DEHT had no adverse effect but elevated production (11-14%) induced up-regulation antioxidant genes, including SOD1. findings indicate could negatively affect cellular response, leads without detrimental effects viability.

Язык: Английский

---

A study on the estrogenic effects of Benzophenone-2 in adult ovariectomized mice

The Journal of Basic and Applied Zoology, Год журнала: 2025, Номер 86(1)

Опубликована: Апрель 17, 2025

Abstract Background Benzophenone-2 (BP2) is an ultraviolet absorber extensively used in personal care products. Due to rising infertility issues and scarce scientific data on its effect female reproductive health, this study aimed investigate the possible estrogenic effects of BP2 adult mice following bilateral ovariectomy. Experimental were randomly assigned 6 groups, The Sham OVX Control groups received subcutaneous olive oil treatment, while other three administered with subcutaneously daily at a dose 50,100 200 mg/kg bw for time frame 7 21 days consecutively alongside positive 17β-estradiol group 1 µg/kg two successive periods (7 days) too. activity was assessed through vaginal cornification, uterine weight, serum estrogen, progesterone, FSH LH levels, histopathological analysis uterus. Results different concentrations treated ovariectomized increased cornification (20.0 ± 1.6% 50.6 0.7% respectively bw; P < 0.001), weight (0.062 0 g estradiol levels (17.4 1.6 pg/ml 0.05) compared group. Histopathological uterus revealed atrophy untreated At same time, BP2-treated exhibited enhanced endometrial glands, proliferative luminal epithelial cells, lumen size, myometrial response. These comparable those observed Conclusion (BP2), may possess mice, could induce modifications as well interference normal hormone balance function.

Язык: Английский

---

A toxicological perspective on climate change and the exposome

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Апрель 8, 2024

Climate change is accompanied by changes in the exposome, including increased heat, ground-level ozone, and other air pollutants, infectious agents, pollens, psychosocial stress. These exposures alter internal component of exposome account for some health effects climate change. The adverse outcome pathways describe biological events leading to an unfavorable outcome. In this perspective study, I propose use toxicological framework better steps linking a stressor associated with Such also allows identification possible interactions between stressors related others, such as chemical pollution. More generally, call incorporation part improved involved its effects.

Язык: Английский

---

Flaxseed oil attenuates PFOS-induced testicular damage by regulating RNA alternative splicing

Food & Function, Год журнала: 2024, Номер 15(19), С. 10007 - 10019

Опубликована: Янв. 1, 2024

: Perfluorooctane sulfonate (PFOS) is a persistent, widely present environmental pollutant, and its toxicity to male reproduction has gradually attracted attention. Flaxseed oil (FO) dietary abundant in α-linolenic acid been demonstrated possess multiple health benefits. However, whether FO protects against PFOS-induced testicular injury mechanism remain unclear.

Язык: Английский

---