European Journal of Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Several
studies
have
reported
associations
between
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
the
risk
of
various
cancers.
However,
focusing
specifically
on
association
MASLD
thyroid
cancer
are
relatively
limited,
conclusions
drawn,
thus,
far
remain
inconclusive.
In
response,
we
conducted
a
meta-analysis
relevant
cohort
to
clarify
cancer.
We
systematically
searched
Web
Science,
Embase,
Cochrane
Library,
PubMed
databases
for
articles
published
before
24
September
2024.
utilized
R
software
(version
4.4.1)
comprehensive
execution
all
statistical
analyses.
Our
included
eight
(six
retrospective
two
prospective),
comprising
18
925
396
participants.
The
pooled
results
indicate
that
is
linked
an
increased
(HR
=
1.46;
95%
CI:
1.14–1.86;
I
²
69%;
P
<
0.01).
A
random-effects
model
was
employed
due
moderate
heterogeneity
(
>
50%).
Subgroup
analyses
revealed
stronger
in
Chinese
population
2.24;
1.32–3.81;
51%)
among
overweight
individuals
1.29;
1.02–1.63;
90%).
No
significant
differences
were
identified
male
female
subgroups.
This
demonstrates
increases
developing
European Journal of Clinical Investigation,
Год журнала:
2024,
Номер
54(11)
Опубликована: Июнь 28, 2024
Abstract
Background
Numerous
recent
studies
have
explored
the
association
between
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD)
and
risk
of
various
extrahepatic
cancers.
However,
conclusions
were
inconclusive.
The
aim
this
study
was
to
clarify
relationship
by
conducting
a
robust
meta‐analysis.
Methods
Systematic
searches
conducted
on
PubMed,
Embase
Web
Science
databases
identify
relevant
cohort
published
prior
February
2024.
Hazard
ratios
(HRs)
their
corresponding
95%
confidence
intervals
(95%
CIs)
combined
using
random‐effects
model
in
Results
Eighteen
(approximately
16.7
million
participants)
finally
included
MASLD
linked
higher
cancers,
such
as
gastric
(
n
=
10,
HR
1.47,
CI:
1.07–2.01),
colorectal
13,
1.33,
1.16–1.53),
pancreatic
8,
1.41,
1.11–1.79),
biliary
tract
5,
1.27,
1.18–1.37),
thyroid
6,
1.46,
1.02–2.09),
urinary
system
1.45,
1.25–1.69),
breast
11,
1.17,
1.08–1.26)
female
genital
organ
cancers
1.36,
1.11–1.66).
there
no
statistically
significant
head
neck
1.03,
99–1.07),
oesophageal
9,
1.26,
0.86–1.86),
lung
1.01,
0.92–1.10),
prostate
1.06,
0.94–1.19)
or
small
intestine
cancer
2,
1.75,
1.00–3.06).
Conclusions
This
latest
large‐scale
meta‐analysis
indicated
that
associated
with
an
increased
gastric,
colorectal,
pancreatic,
duct,
thyroid,
system,
breast,
skin
Further
research
is
needed
investigate
mechanisms
underlying
these
associations.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 9, 2024
Background
and
aims
In
recent
years,
the
relationship
between
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
colorectal
cancer
(CRC)
or
adenoma
(CRA)
has
gained
widespread
attention.
Previous
meta-analyses
on
this
subject
either
incorporated
numerous
cross-sectional
studies,
which
were
susceptible
to
bias,
concentrated
solely
a
restricted
number
of
cohort
studies.
Moreover,
with
release
substantial
high-quality
studies
in
past
two
findings
continue
be
debated
contradictory.
Therefore,
we
conducted
an
updated
systematic
review
meta-analysis
quantitatively
evaluate
magnitude
association
them.
Methods
Comprehensive
searches
PubMed,
Web
Science,
Embase
without
language
restrictions
from
time
their
creation
up
December,
2023.
The
pooled
hazard
ratios
(HRs)
95%
confidence
interval
(CIs)
calculated
by
generic
inverse
variance
based
random-effects
model.
subgroup
sensitivity
analyses
performed.
Results
A
total
15
analyzed
meta-analysis,
included
9,958,412
participants.
13
showed
that
MASLD
was
linked
higher
risk
CRC
(HR=1.25,
CI:
1.15-1.36,
P
<
0.00001).
Additionally,
further
analysis
indicated
combined
HR
remained
consistent
regardless
study
location,
nomenclature
fatty
(FLD),
confirmation
methods
for
FLD,
sample
size,
follow-up
time,
quality.
Furthermore,
four
demonstrated
correlated
increased
CRA
(HR=1.38,
1.17-1.64,
=
0.0002).
results
validated
robustness
aboved
findings.
Conclusion
our
associated
incident
CRC/CRA.
future,
it
is
necessary
conduct
more
prospective
thoroughly
assess
potential
confounding
factors,
particularly
individuals
Europe
North
America.
related
mechanism
should
enhance
understanding
link
Systematic
registration
Open
Science
Framework
registries
(
https://osf.io/m3p9k
).
Metabolism and Target Organ Damage,
Год журнала:
2024,
Номер
4(1)
Опубликована: Фев. 22, 2024
A
recent
study
by
Crudele
et
al.
reported
on
the
association
between
surrogate
indices
of
liver
fibrosis
and
risk
gynecological
cancers
among
dysmetabolic
women.
To
put
this
in
context,
notions
regarding
sex
dimorphism
nonalcoholic
fatty
disease
(NAFLD)
are
discussed.
Additionally,
meta-analytic
reviews
extrahepatic
reviewed.
Next,
I
discuss
relationship
metabolic
dysfunction-associated
(MAFLD)
with
cancers,
notably
including
breast
female
reproductive
systems
humans.
The
pathomechanisms
potentially
accounting
for
include
genetics,
deregulated
hormones,
chronic
subclinical
inflammatory
state,
milieu,
oxidative
stress,
gut
dysbiosis,
environmental
pollution,
altered
immune
surveillance.
