Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 14, 2025
Cardiometabolic
diseases
(CMD)
are
leading
causes
of
death
and
disability
worldwide,
with
complex
pathophysiological
mechanisms
in
which
inflammation
plays
a
crucial
role.
This
review
aims
to
elucidate
the
molecular
cellular
within
inflammatory
microenvironment
atherosclerosis,
hypertension
diabetic
cardiomyopathy.
In
oxidized
low-density
lipoprotein
(ox-LDL)
pro-inflammatory
cytokines
such
as
Interleukin-6
(IL-6)
Tumor
Necrosis
Factor-alpha
(TNF-α)
activate
immune
cells
contributing
foam
cell
formation
arterial
wall
thickening.
Hypertension
involves
activation
renin-angiotensin
system
(RAS)
alongside
oxidative
stress-induced
endothelial
dysfunction
local
mediated
by
T
cells.
cardiomyopathy,
high-glucose
environment
leads
accumulation
advanced
glycation
end
products
(AGEs),
activating
Receptor
for
Advanced
Glycation
Endproducts
(RAGE)
triggering
responses
that
further
damage
cardiac
microvascular
function.
summary,
different
types
metabolic
cardiovascular
diverse;
understanding
these
deeply
will
aid
developing
more
effective
individualized
treatment
strategies.
Язык: Английский
Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations
Medicine,
Год журнала:
2025,
Номер
104(11), С. e41861 - e41861
Опубликована: Март 14, 2025
Most
analyses
of
hemoglobin
A1c
(HbA1c)
and
multiple
common
diseases
have
focused
on
European
populations,
thus
there
is
a
need
for
Mendelian
randomization
phenome-wide
association
study
(MR-PheWAS)
in
East
Asian
populations.
We
used
MR-PheWAS
to
investigate
the
potential
causal
associations
between
HbA1c
159
types
Biobank
Japan
dataset,
employing
inverse
variance
weighted
as
primary
statistical
approach,
supplemented
by
MR-Egger
median
analyses.
Additionally,
sensitivity
were
conducted
assess
heterogeneity
pleiotropy.
High
levels
are
associated
with
an
increased
risk
type
1
diabetes
(odds
ratio
[OR]
=
4.07;
95%
confidence
interval
[CI]:
2.34~7.07),
2
(OR
4.76;
CI:
3.01~7.55),
cataract
1.33;
1.18~1.51),
diabetic
nephropathy
5.70;
2.24~14.46),
peripheral
arterial
disease
1.62;
1.29~2.04).
Conversely,
elevated
reduced
asthma
0.76;
0.67~0.86),
breast
cancer
0.75;
0.65~0.87),
cerebral
aneurysm
0.71;
0.57~0.88).
The
results
numerous
populations
provides
insights
region’s
specialized
glycemic
control
prevention
programs,
well
new
preventive
treatment
options.
Язык: Английский
Pharmacological and Computational Investigations of Isosteviol 16-oxime for Attenuating Streptozotocin-induced Diabetic Neuroinflammation utilizing rat as Animal Model
International Immunopharmacology,
Год журнала:
2025,
Номер
153, С. 114506 - 114506
Опубликована: Март 28, 2025
Язык: Английский
Chitosan as a multifunctional polymer in drug delivery systems for diabetic wound management
Polymer Bulletin,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Язык: Английский
Recent Perspectives on the Pharmacological, Nutraceutical, Functional, and Therapeutic Properties of Moringa oleifera Plant
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Апрель 1, 2025
ABSTRACT
The
“miracle
tree,”
Moringa
oleifera
,
has
gained
so
much
attention
because
of
its
spectacular
nutritional
profile
and
potential
health
benefits,
making
it
one
the
candidates
for
functional
food
product
creation.
benefits
M.
are
presented
here
in
this
review
alongside
antioxidant
conformation,
bioactive
constituents,
macro‐
micronutrient
conformation.
is
rapidly
becoming
a
key
effective
component
formulating
healthy
foodstuffs
outstanding
anti‐inflammatory,
antimicrobial,
antidiabetic,
antioxidant,
neuroprotective
activities.
Investigation
into
usage
moringa
products
foods
like
dairy
substitutes,
powders,
supplements,
drinks,
even
snacks
also
part
review.
Notwithstanding
auspicious
there
contests
with
development
such
as
issues
sensory
perception,
active
ingredient
constancy,
budget
constraints.
Maintainable
plant‐based
demand
across
sphere
pushing
novelty
industry.
To
improve
current
scalability
suitability
moringa‐based
foods,
concludes
call
additional
investigation.
Язык: Английский